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Protein
Submitted name:

Exportin-6

Gene

XPO6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Exportin-6Imported
Gene namesi
Name:XPO6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169180.11
HGNCiHGNC:19733 XPO6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169180

PTM / Processingi

Proteomic databases

PeptideAtlasiH3BR41
PRIDEiH3BR41

Expressioni

Gene expression databases

BgeeiENSG00000169180 Expressed in 221 organ(s), highest expression level in blood
ExpressionAtlasiH3BR41 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH3BR41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 83Importin N-terminalInterPro annotationAdd BLAST67

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000002810

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040016 XPO6
PANTHERiPTHR21452 PTHR21452, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

H3BR41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEFFHDCTT NERKREIEEL LNNFAQQIGA WRFCLYFLSS TRNDYVMMYS
60 70 80 90 100
LTVFENLINK MWLGVPSQDK MEIRSCLPKL LLAHHKTLPY FIRNKLCKVI
110 120 130 140
VDIGRQDWPM FYHDFFTNIL QLIQSPVTTP LGLIMLKTTS EE
Length:142
Mass (Da):16,906
Last modified:October 5, 2016 - v8
Checksum:iC221E59CAE968667
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96QU8XPO6_HUMAN
Exportin-6
XPO6 KIAA0370, RANBP20
1,125Annotation score:
I3L2K0I3L2K0_HUMAN
Exportin-6
XPO6
255Annotation score:
H3BMW9H3BMW9_HUMAN
Exportin-6
XPO6
153Annotation score:
I3L0S8I3L0S8_HUMAN
Exportin-6
XPO6
135Annotation score:
H3BRV5H3BRV5_HUMAN
Exportin-6
XPO6
132Annotation score:
H3BPG8H3BPG8_HUMAN
Exportin-6
XPO6
161Annotation score:
H3BRJ6H3BRJ6_HUMAN
Exportin-6
XPO6
17Annotation score:
H3BUP8H3BUP8_HUMAN
Exportin-6
XPO6
21Annotation score:
I3L2D7I3L2D7_HUMAN
Exportin-6
XPO6
19Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei142Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136611 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000570033; ENSP00000456066; ENSG00000169180
UCSCiuc059sma.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136611 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH3BR41
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH3BR41
PRIDEiH3BR41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570033; ENSP00000456066; ENSG00000169180
UCSCiuc059sma.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000169180.11
HGNCiHGNC:19733 XPO6
OpenTargetsiENSG00000169180
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000002810

Miscellaneous databases

ChiTaRSiXPO6 human

Gene expression databases

BgeeiENSG00000169180 Expressed in 221 organ(s), highest expression level in blood
ExpressionAtlasiH3BR41 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR040016 XPO6
PANTHERiPTHR21452 PTHR21452, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BR41_HUMAN
AccessioniPrimary (citable) accession number: H3BR41
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 46 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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