UniProtKB - H3BR01 (H3BR01_HUMAN)
Protein
Submitted name:
Kunitz-type protease inhibitor 1
Gene
SPINT1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Kunitz-type protease inhibitor 1Imported |
Gene namesi | Name:SPINT1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11246 SPINT1 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 216 – 239 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | H3BR01 |
PeptideAtlasi | H3BR01 |
PRIDEi | H3BR01 |
ProteomicsDBi | 41934 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166145 Expressed in 171 organ(s), highest expression level in lower esophagus mucosa |
ExpressionAtlasi | H3BR01 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 118 | BPTI/Kunitz inhibitorInterPro annotationAdd BLAST | 51 | |
Domaini | 151 – 201 | BPTI/Kunitz inhibitorInterPro annotationAdd BLAST | 51 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000161683 |
Family and domain databases
CDDi | cd00109 KU, 2 hits |
Gene3Di | 2.60.40.10, 1 hit 4.10.410.10, 2 hits |
InterProi | View protein in InterPro IPR013783 Ig-like_fold IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS IPR042482 Spint1 |
PANTHERi | PTHR46750 PTHR46750, 2 hits |
Pfami | View protein in Pfam PF00014 Kunitz_BPTI, 2 hits |
PRINTSi | PR00759 BASICPTASE |
SMARTi | View protein in SMART SM00131 KU, 2 hits |
SUPFAMi | SSF57362 SSF57362, 2 hits |
PROSITEi | View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
H3BR01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XVENTDWRLL RGDTDVRVER KDPNQVELWG LKEGTYLFQL TVTSSDHPED
60 70 80 90 100
TANVTVTVLS TKQTEDYCLA SNKVGRCRGS FPRWYYDPTE QICKSFVYGG
110 120 130 140 150
CLGNKNNYLR EEECILACRG VQGPSMERRH PDTSGFDELQ RIHFPSDKGH
160 170 180 190 200
CVDLPDTGLC KESIPRWYYN PFSEHCARFT YGGCYGNKNN FEEEQQCLES
210 220 230 240
CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43278 | SPIT1_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 HAI1, UNQ223/PRO256 | 529 | Annotation score: | ||
H3BVD9 | H3BVD9_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 | 472 | Annotation score: | ||
H3BNW5 | H3BNW5_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 | 204 | Annotation score: | ||
H3BMB6 | H3BMB6_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 | 294 | Annotation score: | ||
H3BSM2 | H3BSM2_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 | 313 | Annotation score: | ||
H3BTQ8 | H3BTQ8_HUMAN | Kunitz-type protease inhibitor 1 | SPINT1 | 301 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 240 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012476 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000566928; ENSP00000456015; ENSG00000166145 |
UCSCi | uc059hvx.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012476 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
jPOSTi | H3BR01 |
PeptideAtlasi | H3BR01 |
PRIDEi | H3BR01 |
ProteomicsDBi | 41934 |
Genome annotation databases
Ensembli | ENST00000566928; ENSP00000456015; ENSG00000166145 |
UCSCi | uc059hvx.1 human |
Organism-specific databases
HGNCi | HGNC:11246 SPINT1 |
OpenTargetsi | ENSG00000166145 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161683 |
Miscellaneous databases
ChiTaRSi | SPINT1 human |
Gene expression databases
Bgeei | ENSG00000166145 Expressed in 171 organ(s), highest expression level in lower esophagus mucosa |
ExpressionAtlasi | H3BR01 baseline and differential |
Family and domain databases
CDDi | cd00109 KU, 2 hits |
Gene3Di | 2.60.40.10, 1 hit 4.10.410.10, 2 hits |
InterProi | View protein in InterPro IPR013783 Ig-like_fold IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS IPR042482 Spint1 |
PANTHERi | PTHR46750 PTHR46750, 2 hits |
Pfami | View protein in Pfam PF00014 Kunitz_BPTI, 2 hits |
PRINTSi | PR00759 BASICPTASE |
SMARTi | View protein in SMART SM00131 KU, 2 hits |
SUPFAMi | SSF57362 SSF57362, 2 hits |
PROSITEi | View protein in PROSITE PS00280 BPTI_KUNITZ_1, 2 hits PS50279 BPTI_KUNITZ_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BR01_HUMAN | |
Accessioni | H3BR01Primary (citable) accession number: H3BR01 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | July 31, 2019 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |