UniProtKB - H3BQV9 (H3BQV9_HUMAN)
Protein
Submitted name:
G-protein-coupled receptor family C group 5 member B
Gene
GPRC5B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: G-protein-coupled receptor family C group 5 member BImported |
Gene namesi | Name:GPRC5BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167191.11 |
HGNCi | HGNC:13308, GPRC5B |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 81 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 93 – 115 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 127 – 145 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5003581471 | 28 – 148 | Sequence analysisAdd BLAST | 121 |
Proteomic databases
PeptideAtlasi | H3BQV9 |
PRIDEi | H3BQV9 |
ProteomicsDBi | 41896 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167191, Expressed in medial globus pallidus and 229 other tissues |
ExpressionAtlasi | H3BQV9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 148 | G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST | 54 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_1762965_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H3BQV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVASERKMR AHQVLTFLLL FVITSVASEN ASTSRGCGLD LLPQYVSLCD
60 70 80 90 100
LDAIWGIVVE AVAGAGALIT LLLMLILLVR LPFIKEKEKK SPVGLHFLFL
110 120 130 140
LGTLGLFGLT FAFIIQEDET ICSVRRFLWG VLFALCFSCL LSQAWRVR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NZH0 | GPC5B_HUMAN | G-protein coupled receptor family C... | GPRC5B RAIG2 | 403 | Annotation score: | ||
H3BN33 | H3BN33_HUMAN | G-protein-coupled receptor family C... | GPRC5B | 177 | Annotation score: | ||
H3BSJ1 | H3BSJ1_HUMAN | G-protein-coupled receptor family C... | GPRC5B | 86 | Annotation score: | ||
H3BT93 | H3BT93_HUMAN | G-protein-coupled receptor family C... | GPRC5B | 90 | Annotation score: | ||
H3BT47 | H3BT47_HUMAN | G-protein-coupled receptor family C... | GPRC5B | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 148 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134300 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000562469; ENSP00000455960; ENSG00000167191 |
UCSCi | uc059rpe.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134300 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | H3BQV9 |
PRIDEi | H3BQV9 |
ProteomicsDBi | 41896 |
Protocols and materials databases
Antibodypediai | 12141, 294 antibodies |
Genome annotation databases
Ensembli | ENST00000562469; ENSP00000455960; ENSG00000167191 |
UCSCi | uc059rpe.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167191.11 |
HGNCi | HGNC:13308, GPRC5B |
OpenTargetsi | ENSG00000167191 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_1762965_0_0_1 |
Miscellaneous databases
ChiTaRSi | GPRC5B, human |
Gene expression databases
Bgeei | ENSG00000167191, Expressed in medial globus pallidus and 229 other tissues |
ExpressionAtlasi | H3BQV9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BQV9_HUMAN | |
Accessioni | H3BQV9Primary (citable) accession number: H3BQV9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |