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UniProtKB - H3BQK9 (H3BQK9_HUMAN)

Entry version 80 (19 Jan 2022)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7192 – 7203PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7228 – 7239PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13664, MACF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotationARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		H3BQK9

PeptideAtlas

More...PeptideAtlasi		H3BQK9

PRoteomics IDEntifications database

More...PRIDEi		H3BQK9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		41815

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127603, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		H3BQK9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		H3BQK9, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		H3BQK9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 213Calponin-homology (CH)InterPro annotationAdd BLAST136
Domaini226 – 330Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini900 – 957SH3InterPro annotationAdd BLAST58
Domaini7179 – 7214EF-handInterPro annotationAdd BLAST36
Domaini7215 – 7250EF-handInterPro annotationAdd BLAST36
Domaini7255 – 7333GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni2083 – 2124DisorderedSequence analysisAdd BLAST42
Regioni3045 – 3066DisorderedSequence analysisAdd BLAST22
Regioni3136 – 3206DisorderedSequence analysisAdd BLAST71
Regioni3353 – 3382DisorderedSequence analysisAdd BLAST30
Regioni5724 – 5744DisorderedSequence analysisAdd BLAST21
Regioni7089 – 7119DisorderedSequence analysisAdd BLAST31
Regioni7336 – 7427DisorderedSequence analysisAdd BLAST92
Regioni7447 – 7592DisorderedSequence analysisAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili277 – 297Sequence analysisAdd BLAST21
Coiled coili509 – 529Sequence analysisAdd BLAST21
Coiled coili534 – 561Sequence analysisAdd BLAST28
Coiled coili853 – 873Sequence analysisAdd BLAST21
Coiled coili1078 – 1098Sequence analysisAdd BLAST21
Coiled coili1435 – 1465Sequence analysisAdd BLAST31
Coiled coili1529 – 1549Sequence analysisAdd BLAST21
Coiled coili1554 – 1574Sequence analysisAdd BLAST21
Coiled coili3427 – 3454Sequence analysisAdd BLAST28
Coiled coili3478 – 3498Sequence analysisAdd BLAST21
Coiled coili3600 – 3638Sequence analysisAdd BLAST39
Coiled coili3728 – 3762Sequence analysisAdd BLAST35
Coiled coili3892 – 3922Sequence analysisAdd BLAST31
Coiled coili4286 – 4313Sequence analysisAdd BLAST28
Coiled coili4333 – 4353Sequence analysisAdd BLAST21
Coiled coili4391 – 4411Sequence analysisAdd BLAST21
Coiled coili4496 – 4516Sequence analysisAdd BLAST21
Coiled coili4656 – 4676Sequence analysisAdd BLAST21
Coiled coili4715 – 4735Sequence analysisAdd BLAST21
Coiled coili4756 – 4790Sequence analysisAdd BLAST35
Coiled coili4907 – 4927Sequence analysisAdd BLAST21
Coiled coili5028 – 5069Sequence analysisAdd BLAST42
Coiled coili5232 – 5252Sequence analysisAdd BLAST21
Coiled coili5343 – 5363Sequence analysisAdd BLAST21
Coiled coili5996 – 6016Sequence analysisAdd BLAST21
Coiled coili6229 – 6256Sequence analysisAdd BLAST28
Coiled coili6441 – 6461Sequence analysisAdd BLAST21
Coiled coili7008 – 7028Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 28Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi2085 – 2108Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi3157 – 3196Polar residuesSequence analysisAdd BLAST40
Compositional biasi5728 – 5743Polar residuesSequence analysisAdd BLAST16
Compositional biasi7343 – 7359Polar residuesSequence analysisAdd BLAST17
Compositional biasi7391 – 7427Polar residuesSequence analysisAdd BLAST37
Compositional biasi7462 – 7507Polar residuesSequence analysisAdd BLAST46
Compositional biasi7539 – 7592Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000015_0_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		VIKLCEM

Database for complete collections of gene phylogenies

More...PhylomeDBi		H3BQK9

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 20 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

H3BQK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH 
        60         70         80         90        100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN 
       110        120        130        140        150
DLYEDLRDGH NLISLLEVLS GIKLEPAGLK TLRLVSMPSW CHTNNEEQAE 
       160        170        180        190        200
EDDDDVPREK GRMRFHRLQN VQIALDFLKQ RQVKLVNIRN DDITDGNPKL 
       210        220        230        240        250
TLGLIWTIIL HFQISDIYIS GESGDMSAKE KLLLWTQKVT AGYTGIKCTN 
       260        270        280        290        300
FSSCWSDGKM FNALIHRYRP DLVDMERVQI QSNRENLEQA FEVAERLGVT 
       310        320        330        340        350
RLLDAEDVDV PSPDEKSVIT YVSSIYDAFP KVPEGGEGIS ATEVDSRWQE 
       360        370        380        390        400
YQSRVDSLIP WIKQHTILMS DKTFPQNPVE LKALYNQYIH FKETEILAKE 
       410        420        430        440        450
REKGRIEELY KLLEVWIEFG RIKLPQGYHP NDVEEEWGKL IIEMLEREKS 
       460        470        480        490        500
LRPAVERLEL LLQIANKIQN GALNCEEKLT LAKNTLQADA AHLESGQPVQ 
       510        520        530        540        550
CESDVIMYIQ ECEGLIRQLQ VDLQILRDEN YYQLEELAFR VMRLQDELVT 
       560        570        580        590        600
LRLECTNLYR KGHFTSLELV PPSTLTTTHL KAEPLTKATH SSSTSWFRKP 
       610        620        630        640        650
MTRAELVAIS SSEDEGNLRF VYELLSWVEE MQMKLERAEW GNDLPSVELQ 
       660        670        680        690        700
LETQQHIHTS VEELGSSVKE ARLYEGKMSQ NFHTSYAETL GKLETQYCKL 
       710        720        730        740        750
KETSSFRMRH LQSLHKFVSR ATAELIWLNE KEEEELAYDW SDNNSNISAK 
       760        770        780        790        800
RNYFSELTME LEEKQDVFRS LQDTAELLSL ENHPAKQTVE AYSAAVQSQL 
       810        820        830        840        850
QWMKQLCLCV EQHVKENTAY FQFFSDAREL ESFLRNLQDS IKRKYSCDHN 
       860        870        880        890        900
TSLSRLEDLL QDSMDEKEQL IQSKSSVASL VGRSKTIVQL KPRSPDHVLK 
       910        920        930        940        950
NTISVKAVCD YRQIEITICK NDECVLEDNS QRTKWKVISP TGNEAMVPSV 
       960        970        980        990       1000
CFLIPPPNKD AIEMASRVEQ SYQKVMALWH QLHVNTKSLI SWNYLRKDLD 
      1010       1020       1030       1040       1050
LVQTWNLEKL RSSAPGECHQ IMKNLQAHYE DFLQDSRDSV LFSVADRLRL 
      1060       1070       1080       1090       1100
EEEVEACKAR FQHLMKSMEN EDKEETVAKM YISELKNIRL RLEEYEQRVV 
      1110       1120       1130       1140       1150
KRIQSLASSR TDRDAWQDNA LRIAEQEHTQ EDLQQLRSDL DAVSMKCDSF 
      1160       1170       1180       1190       1200
LHQSPSSSSV PTLRSELNLL VEKMDHVYGL STVYLNKLKT VDVIVRSIQD 
      1210       1220       1230       1240       1250
AELLVKGYEI KLSQEEVVLA DLSALEAHWS TLRHWLSDVK DKNSVFSVLD 
      1260       1270       1280       1290       1300
EEIAKAKVVA EQMSRLTPER NLDLERYQEK GSQLQERWHR VIAQLEIRQS 
      1310       1320       1330       1340       1350
ELESIQEVLG DYRACHGTLI KWIEETTAQQ EMMKPGQAED SRVLSEQLSQ 
      1360       1370       1380       1390       1400
QTALFAEIER NQTKLDQCQK FSQQYSTIVK DYELQLMTYK AFVESQQKSP 
      1410       1420       1430       1440       1450
GKRRRMLSSS DAITQEFMDL RTRYTALVTL TTQHVKYISD ALRRLEEEEK 
      1460       1470       1480       1490       1500
VVEEEKQEHV EKVKELLGWV STLARNTQGK ATSSETKEST DIEKAILEQQ 
      1510       1520       1530       1540       1550
VLSEELTTKK EQVSEAIKTS QIFLAKHGHK LSEKEKKQIS EQLNALNKAY 
      1560       1570       1580       1590       1600
HDLCDGSANQ LQQLQSQLAH QTEQKECRAV AGVIDLGTVE IFPIFKAMQK 
      1610       1620       1630       1640       1650
GLLDQDTGLV LLESQVIMSG LIAPETGENL SLEEGIARNL INPQMYQQLR 
      1660       1670       1680       1690       1700
ELQDALALIS RLTESRGPLS VVEAIEKRII SETVGLKILE AHLATGGFSL 
      1710       1720       1730       1740       1750
SPSENCINLE EAFHQGLISA WLHSVLESYL RTSKNLIDPN TAEKIGLLDL 
      1760       1770       1780       1790       1800
MQRCIVHQES GFKLLPVKQL AGGMVSLKSG RKVSIFRAVQ EGLIDRQVTV 
      1810       1820       1830       1840       1850
RLLEAQLFAG GIVDPRTGHR LTVEEAVRHN LIDQDMACAI LIRQLQTGGI 
      1860       1870       1880       1890       1900
IDTVTGQRLT IDEAVSNDLV AAKIALVILE SLWSFMGLLW PESGEILPIT 
      1910       1920       1930       1940       1950
DALEQGIVST ELAHKILSNR QHIKALFLPA TTEILSWKKA IESGILDRDL 
      1960       1970       1980       1990       2000
ANNLKSICIP DVMPHMQLAD SAEQNINPGA AVLPCSKSHP KATASQSENL 
      2010       2020       2030       2040       2050
LFQLMTHSYI NVQNGQRLLL LDKELMETLT SRDEYQTSPP KVVEIGHQRQ 
      2060       2070       2080       2090       2100
KTPEGLQESA NVKISGTFSS GWTVRLPEFQ FSSQNKEYPD REDCTTEKGK 
      2110       2120       2130       2140       2150
KTTVETEDSS VENPEQDLFV EQKERNPNID ALKVINKVKL EVQRQLIGTQ 
      2160       2170       2180       2190       2200
REDQTAVSVR ENASRGHLLT IPPAEAEGVP LVVDKDVFSV ETPKKEHQPL 
      2210       2220       2230       2240       2250
RNTSFTCQNE QAHTLETEYI HDETGGSHIK PQSKKLQVQV KKTLGIKLEL 
      2260       2270       2280       2290       2300
KSETDGNVHP LDKKEMLKKT FLAKDDHKES QEAQNIAGGS MMMSEKTDEE 
      2310       2320       2330       2340       2350
DSGREIFLSC SHPLELLEEA TLNVLSAQLL DGGIFHEQTG QKLLLNEAIS 
      2360       2370       2380       2390       2400
RGIVPSHTAV KLMEKLNMFQ GFFDSQTCES LTTEEVINEG LMDEKLLHNV 
      2410       2420       2430       2440       2450
LMADKAISGV LDPRTQTLCS VKDAVTVGLL DKETATRILE RQVVTGGIID 
      2460       2470       2480       2490       2500
LKRGKKVSVT LASTLGLVDV ADQPELINLE KASKGRDAEK TVRERLISLQ 
      2510       2520       2530       2540       2550
METTGLIDPD SKAPLTVVQS IDRGLLEREE AVRLLTKQVV DGGIIHHISG 
      2560       2570       2580       2590       2600
MRLSVDNAFR HGLIGEDLAE KLKRVENLNI HQIFNPETKE NISLPKAIKL 
      2610       2620       2630       2640       2650
DLITSDLKRE IQEVQAFTGN FVDLISGQRL TLAEAKKEGL LTNEAVLSPG 
      2660       2670       2680       2690       2700
MMHGIVDPEN CRIVPYSELV KKCKIDIESG QRYLEVIPFS DIKDGVSDKV 
      2710       2720       2730       2740       2750
LTLSQAIQLG KVDFASTLKV LEAQANTGGI IDTATGKRLT LASALEEKLV 
      2760       2770       2780       2790       2800
DENMVRIIAS HQVLNGGIVD IFSDQRVTLV EAIEKRLISP ELANMIQIDS 
      2810       2820       2830       2840       2850
SEFSDHRAQI EKQEGIEVCA LQNEFLGKDM LIACNQTAEM SCNKVEESER 
      2860       2870       2880       2890       2900
LFQVENQSAQ EKVKVRVSDG EQAKKSREIS LKEFGCKDQR KPRMSSDAKE 
      2910       2920       2930       2940       2950
FISIINPHNL KGKSLGQVSL THPYSECDFK LKEVARNNMG NDTNEEQEKA 
      2960       2970       2980       2990       3000
VTKIEIISHM KQSTSCLDSE EIRENQGEVI LEVQETYCET SGKLPSEQVL 
      3010       3020       3030       3040       3050
QQPMNARVKS KREKREVIVE ESIRTCKPAF LSEEKLYQET AIRDEHDSHI 
      3060       3070       3080       3090       3100
KSQPREMTSS EKGKEADTEM GFSITFKIEE SSSQVVPQGI SVKHLDALTL 
      3110       3120       3130       3140       3150
FSSKQANEGK VNNLSLCLTL KPEENLSREI ACGAQSEPFP CMTPRPEGLH 
      3160       3170       3180       3190       3200
YQESDGKAQV TGPSQISKTD KSFQGTTRQE TNYQDSWVTS KTKETKHQIS 
      3210       3220       3230       3240       3250
SSNECKEKSY QEVSFDPARG LKLEEITVSR PDSKEVRYLE FSDRKDLHHQ 
      3260       3270       3280       3290       3300
GSKSDDKLCG TLKSEIATQE LTGEKFLEMA NPNVAGLEAG SIEDIVTQRG 
      3310       3320       3330       3340       3350
SRVLGSFLPE KLFKGVSQKE NTGQQNAIIS PTVLETSEEK TVSLTVCSAV 
      3360       3370       3380       3390       3400
KTEKTPQEKL RESPGSEQTP FMTAPEGKGN GGVNPEPFRA TQNVFTRQLC 
      3410       3420       3430       3440       3450
LEHDEKLVSY LSLLRNIEMR TKQIQPLELN LAELQDLLCQ AKVLERELKD 
      3460       3470       3480       3490       3500
LTTLVSQELE CVNQIIISQP QEVPAQLLKA LEKDAKNLQK SLSSVSDTWN 
      3510       3520       3530       3540       3550
SRLLHFQNAV EIEKTKVLNQ HTQLEGRLQD LRAWVGNKNL ILNSKGSNSE 
      3560       3570       3580       3590       3600
IDVDSLNLCL QQYEDLKQPM AERKAQLDAL AFDIQFFISE HAQDLSPQQN 
      3610       3620       3630       3640       3650
RQMLRLLNEL QRSFQDILEQ TAAQVDALQG HLQQMEQEAL VKTLQKQQNT 
      3660       3670       3680       3690       3700
CHQQLEDLCS WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN 
      3710       3720       3730       3740       3750
RATSFATVVK DIEGFMEENQ TKLSPRELTA LREKLHQAKE QYEALQEETR 
      3760       3770       3780       3790       3800
VAQKELEEAV TSALQQETEK SKAAKELAEN KKKIDALLDW VTSVGSSGGQ 
      3810       3820       3830       3840       3850
LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ CEMMKARHQE 
      3860       3870       3880       3890       3900
LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA 
      3910       3920       3930       3940       3950
QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL 
      3960       3970       3980       3990       4000
PSLLKRQGSF SEDVISHKGD LRFVTISGQK VLDMENSFKE GKEPSEIGNL 
      4010       4020       4030       4040       4050
VKDKLKDATE RYTALHSKCT RLGSHLNMLL GQYHQFQNSA DSLQAWMQAC 
      4060       4070       4080       4090       4100
EANVEKLLSD TVASDPGVLQ EQLATTKQLQ EELAEHQVPV EKLQKVARDI 
      4110       4120       4130       4140       4150
MEIEGEPAPD HRHVQETTDS ILSHFQSLSY SLAERSSLLQ KAIAQSQSVQ 
      4160       4170       4180       4190       4200
ESLESLLQSI GEVEQNLEGK QVSSLSSGVI QEALATNMKL KQDIARQKSS 
      4210       4220       4230       4240       4250
LEATREMVTR FMETADSTTA AVLQGKLAEV SQRFEQLCLQ QQEKESSLKK 
      4260       4270       4280       4290       4300
LLPQAEMFEH LSGKLQQFME NKSRMLASGN QPDQDITHFF QQIQELNLEM 
      4310       4320       4330       4340       4350
EDQQENLDTL EHLVTELSSC GFALDLCQHQ DRVQNLRKDF TELQKTVKER 
      4360       4370       4380       4390       4400
EKDASSCQEQ LDEFRKLVRT FQKWLKETEG SIPPTETSMS AKELEKQIEH 
      4410       4420       4430       4440       4450
LKSLLDDWAS KGTLVEEINC KGTSLENLIM EITAPDSQGK TGSILPSVGS 
      4460       4470       4480       4490       4500
SVGSVNGYHT CKDLTEIQCD MSDVNLKYEK LGGVLHERQE SLQAILNRME 
      4510       4520       4530       4540       4550
EVHKEANSVL QWLESKEEVL KSMDAMSSPT KTETVKAQAE SNKAFLAELE 
      4560       4570       4580       4590       4600
QNSPKIQKVK EALAGLLVTY PNSQEAENWK KIQEELNSRW ERATEVTVAR 
      4610       4620       4630       4640       4650
QRQLEESASH LACFQAAESQ LRPWLMEKEL MMGVLGPLSI DPNMLNAQKQ 
      4660       4670       4680       4690       4700
QVQFMLKEFE ARRQQHEQLN EAAQGILTGP GDVSLSTSQV QKELQSINQK 
      4710       4720       4730       4740       4750
WVELTDKLNS RSSQIDQAIV KSTQYQELLQ DLSEKVRAVG QRLSVQSAIS 
      4760       4770       4780       4790       4800
TQPEAVKQQL EETSEIRSDL EQLDHEVKEA QTLCDELSVL IGEQYLKDEL 
      4810       4820       4830       4840       4850
KKRLETVALP LQGLEDLAAD RINRLQAALA STQQFQQMFD ELRTWLDDKQ 
      4860       4870       4880       4890       4900
SQQAKNCPIS AKLERLQSQL QENEEFQKSL NQHSGSYEVI VAEGESLLLS 
      4910       4920       4930       4940       4950
VPPGEEKRTL QNQLVELKNH WEELSKKTAD RQSRLKDCMQ KAQKYQWHVE 
      4960       4970       4980       4990       5000
DLVPWIEDCK AKMSELRVTL DPVQLESSLL RSKAMLNEVE KRRSLLEILN 
      5010       5020       5030       5040       5050
SAADILINSS EADEDGIRDE KAGINQNMDA VTEELQAKTG SLEEMTQRLR 
      5060       5070       5080       5090       5100
EFQESFKNIE KKVEGAKHQL EIFDALGSQA CSNKNLEKLR AQQEVLQALE 
      5110       5120       5130       5140       5150
PQVDYLRNFT QGLVEDAPDG SDASQLLHQA EVAQQEFLEV KQRVNSGCVM 
      5160       5170       5180       5190       5200
MENKLEGIGQ FHCRVREMFS QLADLDDELD GMGAIGRDTD SLQSQIEDVR 
      5210       5220       5230       5240       5250
LFLNKIHVLK LDIEASEAEC RHMLEEEGTL DLLGLKRELE ALNKQCGKLT 
      5260       5270       5280       5290       5300
ERGKARQEQL ELTLGRVEDF YRKLKGLNDA TTAAEEAEAL QWVVGTEVEI 
      5310       5320       5330       5340       5350
INQQLADFKM FQKEQVDPLQ MKLQQVNGLG QGLIQSAGKD CDVQGLEHDM 
      5360       5370       5380       5390       5400
EEINARWNTL NKKVAQRIAQ LQEALLHCGK FQDALEPLLS WLADTEELIA 
      5410       5420       5430       5440       5450
NQKPPSAEYK VVKAQIQEQK LLQRLLDDRK ATVDMLQAEG GRIAQSAELA 
      5460       5470       5480       5490       5500
DREKITGQLE SLESRWTELL SKAAARQKQL EDILVLAKQF HETAEPISDF 
      5510       5520       5530       5540       5550
LSVTEKKLAN SEPVGTQTAK IQQQIIRHKA LEEDIENHAT DVHQAVKIGQ 
      5560       5570       5580       5590       5600
SLSSLTSPAE QGVLSEKIDS LQARYSEIQD RCCRKAALLD QALSNARLFG 
      5610       5620       5630       5640       5650
EDEVEVLNWL AEVEDKLSSV FVKDFKQDVL HRQHADHLAL NEEIVNRKKN 
      5660       5670       5680       5690       5700
VDQAIKNGQA LLKQTTGEEV LLIQEKLDGI KTRYADITVT SSKALRTLEQ 
      5710       5720       5730       5740       5750
ARQLATKFQS TYEELTGWLR EVEEELATSG GQSPTGEQIP QFQQRQKELK 
      5760       5770       5780       5790       5800
KEVMEHRLVL DTVNEVSRAL LELVPWRARE GLDKLVSDAN EQYKLVSDTI 
      5810       5820       5830       5840       5850
GQRVDEIDAA IQRSQQYEQA ADAELAWVAE TKRKLMALGP IRLEQDQTTA 
      5860       5870       5880       5890       5900
QLQVQKAFSI DIIRHKDSMD ELFSHRSEIF GTCGEEQKTV LQEKTESLIQ 
      5910       5920       5930       5940       5950
QYEAISLLNS ERYARLERAQ VLVNQFWETY EELSPWIEET RALIAQLPSP 
      5960       5970       5980       5990       6000
AIDHEQLRQQ QEEMRQLRES IAEHKPHIDK LLKIGPQLKE LNPEEGEMVE 
      6010       6020       6030       6040       6050
EKYQKAENMY AQIKEEVRQR ALALDEAVSQ STQFHDKIEP MLETLENLSS 
      6060       6070       6080       6090       6100
RLRMPPLIPA EVDKIRECIS DNKSATVELE KLQPSFEALK RRGEELIGRS 
      6110       6120       6130       6140       6150
QGADKDLAAK EIQDKLDQMV FFWEDIKARA EEREIKFLDV LELAEKFWYD 
      6160       6170       6180       6190       6200
MAALLTTIKD TQDIVHDLES PGIDPSIIKQ QVEAAETIKE ETDGLHEELE 
      6210       6220       6230       6240       6250
FIRILGADLI FACGETEKPE VRKSIDEMNN AWENLNKTWK ERLEKLEDAM 
      6260       6270       6280       6290       6300
QAAVQYQDTL QAMFDWLDNT VIKLCTMPPV GTDLNTVKDQ LNEMKEFKVE 
      6310       6320       6330       6340       6350
VYQQQIEMEK LNHQGELMLK KATDETDRDI IREPLTELKH LWENLGEKIA 
      6360       6370       6380       6390       6400
HRQHKLEGAL LALGQFQHAL EELMSWLTHT EELLDAQRPI SGDPKVIEVE 
      6410       6420       6430       6440       6450
LAKHHVLKND VLAHQATVET VNKAGNELLE SSAGDDASSL RSRLEAMNQC 
      6460       6470       6480       6490       6500
WESVLQKTEE REQQLQSTLQ QAQGFHSEIE DFLLELTRME SQLSASKPTG 
      6510       6520       6530       6540       6550
GLPETAREQL DTHMELYSQL KAKEETYNQL LDKGRLMLLS RDDSGSGSKT 
      6560       6570       6580       6590       6600
EQSVALLEQK WHVVSSKMEE RKSKLEEALN LATEFQNSLQ EFINWLTLAE 
      6610       6620       6630       6640       6650
QSLNIASPPS LILNTVLSQI EEHKVFANEV NAHRDQIIEL DQTGNQLKFL 
      6660       6670       6680       6690       6700
SQKQDVVLIK NLLVSVQSRW EKVVQRSIER GRSLDDARKR AKQFHEAWKK 
      6710       6720       6730       6740       6750
LIDWLEDAES HLDSELEISN DPDKIKLQLS KHKEFQKTLG GKQPVYDTTI 
      6760       6770       6780       6790       6800
RTGRALKEKT LLPEDSQKLD NFLGEVRDKW DTVCGKSVER QHKLEEALLF 
      6810       6820       6830       6840       6850
SGQFMDALQA LVDWLYKVEP QLAEDQPVHG DLDLVMNLMD AHKVFQKELG 
      6860       6870       6880       6890       6900
KRTGTVQVLK RSGRELIENS RDDTTWVKGQ LQELSTRWDT VCKLSVSKQS 
      6910       6920       6930       6940       6950
RLEQALKQAE VFRDTVHMLL EWLSEAEQTL RFRGALPDDT EALQSLIDTH 
      6960       6970       6980       6990       7000
KEFMKKVEEK RVDVNSAVAM GEVILAVCHP DCITTIKHWI TIIRARFEEV 
      7010       7020       7030       7040       7050
LTWAKQHQQR LETALSELVA NAELLEELLA WIQWAETTLI QRDQEPIPQN 
      7060       7070       7080       7090       7100
IDRVKALIAE HQTFMEEMTR KQPDVDRVTK TYKRKNIEPT HAPFIEKSRS 
      7110       7120       7130       7140       7150
GGRKSLSQPT PPPMPILSQS EAKNPRINQL SARWQQVWLL ALERQRKLND 
      7160       7170       7180       7190       7200
ALDRLEELKE FANFDFDVWR KKYMRWMNHK KSRVMDFFRR IDKDQDGKIT 
      7210       7220       7230       7240       7250
RQEFIDGILA SKFPTTKLEM TAVADIFDRD GDGYIDYYEF VAALHPNKDA 
      7260       7270       7280       7290       7300
YRPTTDADKI EDEVTRQVAQ CKCAKRFQVE QIGENKYRFF LGNQFGDSQQ 
      7310       7320       7330       7340       7350
LRLVRILRST VMVRVGGGWM ALDEFLVKND PCRVHHPGSK IKRSDSSSSI 
      7360       7370       7380       7390       7400
SSQSPIARGR TNIELREKFI LPEGASQGMT PFRSRGRRSK PSSRAASPTR 
      7410       7420       7430       7440       7450
SSSSASQSNH SCTSMPSSPA TPASGTKTSL QFSRCYDKPW LVNSKAGTPI 
      7460       7470       7480       7490       7500
RDSHSPDLQL PTPEVIPSSG SKLKRPTPTF HSSRTSLAGD TSNSSSPAST 
      7510       7520       7530       7540       7550
GAKTNRADPK KSASRPGSRA GSRAGSRASS RRGSDASDFD LLETQSACSD 
      7560       7570       7580       7590 
TSESSAAGGQ GNSRRGLNKP SKIPTMSKKT TTASPRTPGP KR
Length:7,592
Mass (Da):861,078
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2189899D37DA6FAC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJG2A0A590UJG2_HUMAN
Microtubule-actin cross-linking fac...
MACF1
5,379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0MQR8A0A7P0MQR8_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX0A0A5F9ZGX0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000567887; ENSP00000455823; ENSG00000127603

UCSC genome browser

More...UCSCi		uc057ezv.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

SMRiH3BQK9
ModBaseiSearch...

Protein-protein interaction databases

IntActiH3BQK9, 1 interactor

Proteomic databases

MaxQBiH3BQK9
PeptideAtlasiH3BQK9
PRIDEiH3BQK9
ProteomicsDBi41815

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31853, 66 antibodies from 18 providers

Genome annotation databases

EnsembliENST00000567887; ENSP00000455823; ENSG00000127603
UCSCiuc057ezv.1, human

Organism-specific databases

HGNCiHGNC:13664, MACF1
OpenTargetsiENSG00000127603
VEuPathDBiHostDB:ENSG00000127603

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_0_1_1
OMAiVIKLCEM
PhylomeDBiH3BQK9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MACF1, human

Gene expression databases

BgeeiENSG00000127603, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiH3BQK9, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 20 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BQK9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BQK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 19, 2022
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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