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Entry version 80 (19 Jan 2022)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7192 – 7203PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7228 – 7239PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13664, MACF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000127603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotationARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H3BQK9

PeptideAtlas

More...
PeptideAtlasi
H3BQK9

PRoteomics IDEntifications database

More...
PRIDEi
H3BQK9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
41815

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127603, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H3BQK9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
H3BQK9, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H3BQK9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 213Calponin-homology (CH)InterPro annotationAdd BLAST136
Domaini226 – 330Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini900 – 957SH3InterPro annotationAdd BLAST58
Domaini7179 – 7214EF-handInterPro annotationAdd BLAST36
Domaini7215 – 7250EF-handInterPro annotationAdd BLAST36
Domaini7255 – 7333GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni2083 – 2124DisorderedSequence analysisAdd BLAST42
Regioni3045 – 3066DisorderedSequence analysisAdd BLAST22
Regioni3136 – 3206DisorderedSequence analysisAdd BLAST71
Regioni3353 – 3382DisorderedSequence analysisAdd BLAST30
Regioni5724 – 5744DisorderedSequence analysisAdd BLAST21
Regioni7089 – 7119DisorderedSequence analysisAdd BLAST31
Regioni7336 – 7427DisorderedSequence analysisAdd BLAST92
Regioni7447 – 7592DisorderedSequence analysisAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili277 – 297Sequence analysisAdd BLAST21
Coiled coili509 – 529Sequence analysisAdd BLAST21
Coiled coili534 – 561Sequence analysisAdd BLAST28
Coiled coili853 – 873Sequence analysisAdd BLAST21
Coiled coili1078 – 1098Sequence analysisAdd BLAST21
Coiled coili1435 – 1465Sequence analysisAdd BLAST31
Coiled coili1529 – 1549Sequence analysisAdd BLAST21
Coiled coili1554 – 1574Sequence analysisAdd BLAST21
Coiled coili3427 – 3454Sequence analysisAdd BLAST28
Coiled coili3478 – 3498Sequence analysisAdd BLAST21
Coiled coili3600 – 3638Sequence analysisAdd BLAST39
Coiled coili3728 – 3762Sequence analysisAdd BLAST35
Coiled coili3892 – 3922Sequence analysisAdd BLAST31
Coiled coili4286 – 4313Sequence analysisAdd BLAST28
Coiled coili4333 – 4353Sequence analysisAdd BLAST21
Coiled coili4391 – 4411Sequence analysisAdd BLAST21
Coiled coili4496 – 4516Sequence analysisAdd BLAST21
Coiled coili4656 – 4676Sequence analysisAdd BLAST21
Coiled coili4715 – 4735Sequence analysisAdd BLAST21
Coiled coili4756 – 4790Sequence analysisAdd BLAST35
Coiled coili4907 – 4927Sequence analysisAdd BLAST21
Coiled coili5028 – 5069Sequence analysisAdd BLAST42
Coiled coili5232 – 5252Sequence analysisAdd BLAST21
Coiled coili5343 – 5363Sequence analysisAdd BLAST21
Coiled coili5996 – 6016Sequence analysisAdd BLAST21
Coiled coili6229 – 6256Sequence analysisAdd BLAST28
Coiled coili6441 – 6461Sequence analysisAdd BLAST21
Coiled coili7008 – 7028Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 28Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi2085 – 2108Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi3157 – 3196Polar residuesSequence analysisAdd BLAST40
Compositional biasi5728 – 5743Polar residuesSequence analysisAdd BLAST16
Compositional biasi7343 – 7359Polar residuesSequence analysisAdd BLAST17
Compositional biasi7391 – 7427Polar residuesSequence analysisAdd BLAST37
Compositional biasi7462 – 7507Polar residuesSequence analysisAdd BLAST46
Compositional biasi7539 – 7592Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000015_0_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIKLCEM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
H3BQK9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 20 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

H3BQK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH
60 70 80 90 100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN
110 120 130 140 150
DLYEDLRDGH NLISLLEVLS GIKLEPAGLK TLRLVSMPSW CHTNNEEQAE
160 170 180 190 200
EDDDDVPREK GRMRFHRLQN VQIALDFLKQ RQVKLVNIRN DDITDGNPKL
210 220 230 240 250
TLGLIWTIIL HFQISDIYIS GESGDMSAKE KLLLWTQKVT AGYTGIKCTN
260 270 280 290 300
FSSCWSDGKM FNALIHRYRP DLVDMERVQI QSNRENLEQA FEVAERLGVT
310 320 330 340 350
RLLDAEDVDV PSPDEKSVIT YVSSIYDAFP KVPEGGEGIS ATEVDSRWQE
360 370 380 390 400
YQSRVDSLIP WIKQHTILMS DKTFPQNPVE LKALYNQYIH FKETEILAKE
410 420 430 440 450
REKGRIEELY KLLEVWIEFG RIKLPQGYHP NDVEEEWGKL IIEMLEREKS
460 470 480 490 500
LRPAVERLEL LLQIANKIQN GALNCEEKLT LAKNTLQADA AHLESGQPVQ
510 520 530 540 550
CESDVIMYIQ ECEGLIRQLQ VDLQILRDEN YYQLEELAFR VMRLQDELVT
560 570 580 590 600
LRLECTNLYR KGHFTSLELV PPSTLTTTHL KAEPLTKATH SSSTSWFRKP
610 620 630 640 650
MTRAELVAIS SSEDEGNLRF VYELLSWVEE MQMKLERAEW GNDLPSVELQ
660 670 680 690 700
LETQQHIHTS VEELGSSVKE ARLYEGKMSQ NFHTSYAETL GKLETQYCKL
710 720 730 740 750
KETSSFRMRH LQSLHKFVSR ATAELIWLNE KEEEELAYDW SDNNSNISAK
760 770 780 790 800
RNYFSELTME LEEKQDVFRS LQDTAELLSL ENHPAKQTVE AYSAAVQSQL
810 820 830 840 850
QWMKQLCLCV EQHVKENTAY FQFFSDAREL ESFLRNLQDS IKRKYSCDHN
860 870 880 890 900
TSLSRLEDLL QDSMDEKEQL IQSKSSVASL VGRSKTIVQL KPRSPDHVLK
910 920 930 940 950
NTISVKAVCD YRQIEITICK NDECVLEDNS QRTKWKVISP TGNEAMVPSV
960 970 980 990 1000
CFLIPPPNKD AIEMASRVEQ SYQKVMALWH QLHVNTKSLI SWNYLRKDLD
1010 1020 1030 1040 1050
LVQTWNLEKL RSSAPGECHQ IMKNLQAHYE DFLQDSRDSV LFSVADRLRL
1060 1070 1080 1090 1100
EEEVEACKAR FQHLMKSMEN EDKEETVAKM YISELKNIRL RLEEYEQRVV
1110 1120 1130 1140 1150
KRIQSLASSR TDRDAWQDNA LRIAEQEHTQ EDLQQLRSDL DAVSMKCDSF
1160 1170 1180 1190 1200
LHQSPSSSSV PTLRSELNLL VEKMDHVYGL STVYLNKLKT VDVIVRSIQD
1210 1220 1230 1240 1250
AELLVKGYEI KLSQEEVVLA DLSALEAHWS TLRHWLSDVK DKNSVFSVLD
1260 1270 1280 1290 1300
EEIAKAKVVA EQMSRLTPER NLDLERYQEK GSQLQERWHR VIAQLEIRQS
1310 1320 1330 1340 1350
ELESIQEVLG DYRACHGTLI KWIEETTAQQ EMMKPGQAED SRVLSEQLSQ
1360 1370 1380 1390 1400
QTALFAEIER NQTKLDQCQK FSQQYSTIVK DYELQLMTYK AFVESQQKSP
1410 1420 1430 1440 1450
GKRRRMLSSS DAITQEFMDL RTRYTALVTL TTQHVKYISD ALRRLEEEEK
1460 1470 1480 1490 1500
VVEEEKQEHV EKVKELLGWV STLARNTQGK ATSSETKEST DIEKAILEQQ
1510 1520 1530 1540 1550
VLSEELTTKK EQVSEAIKTS QIFLAKHGHK LSEKEKKQIS EQLNALNKAY
1560 1570 1580 1590 1600
HDLCDGSANQ LQQLQSQLAH QTEQKECRAV AGVIDLGTVE IFPIFKAMQK
1610 1620 1630 1640 1650
GLLDQDTGLV LLESQVIMSG LIAPETGENL SLEEGIARNL INPQMYQQLR
1660 1670 1680 1690 1700
ELQDALALIS RLTESRGPLS VVEAIEKRII SETVGLKILE AHLATGGFSL
1710 1720 1730 1740 1750
SPSENCINLE EAFHQGLISA WLHSVLESYL RTSKNLIDPN TAEKIGLLDL
1760 1770 1780 1790 1800
MQRCIVHQES GFKLLPVKQL AGGMVSLKSG RKVSIFRAVQ EGLIDRQVTV
1810 1820 1830 1840 1850
RLLEAQLFAG GIVDPRTGHR LTVEEAVRHN LIDQDMACAI LIRQLQTGGI
1860 1870 1880 1890 1900
IDTVTGQRLT IDEAVSNDLV AAKIALVILE SLWSFMGLLW PESGEILPIT
1910 1920 1930 1940 1950
DALEQGIVST ELAHKILSNR QHIKALFLPA TTEILSWKKA IESGILDRDL
1960 1970 1980 1990 2000
ANNLKSICIP DVMPHMQLAD SAEQNINPGA AVLPCSKSHP KATASQSENL
2010 2020 2030 2040 2050
LFQLMTHSYI NVQNGQRLLL LDKELMETLT SRDEYQTSPP KVVEIGHQRQ
2060 2070 2080 2090 2100
KTPEGLQESA NVKISGTFSS GWTVRLPEFQ FSSQNKEYPD REDCTTEKGK
2110 2120 2130 2140 2150
KTTVETEDSS VENPEQDLFV EQKERNPNID ALKVINKVKL EVQRQLIGTQ
2160 2170 2180 2190 2200
REDQTAVSVR ENASRGHLLT IPPAEAEGVP LVVDKDVFSV ETPKKEHQPL
2210 2220 2230 2240 2250
RNTSFTCQNE QAHTLETEYI HDETGGSHIK PQSKKLQVQV KKTLGIKLEL
2260 2270 2280 2290 2300
KSETDGNVHP LDKKEMLKKT FLAKDDHKES QEAQNIAGGS MMMSEKTDEE
2310 2320 2330 2340 2350
DSGREIFLSC SHPLELLEEA TLNVLSAQLL DGGIFHEQTG QKLLLNEAIS
2360 2370 2380 2390 2400
RGIVPSHTAV KLMEKLNMFQ GFFDSQTCES LTTEEVINEG LMDEKLLHNV
2410 2420 2430 2440 2450
LMADKAISGV LDPRTQTLCS VKDAVTVGLL DKETATRILE RQVVTGGIID
2460 2470 2480 2490 2500
LKRGKKVSVT LASTLGLVDV ADQPELINLE KASKGRDAEK TVRERLISLQ
2510 2520 2530 2540 2550
METTGLIDPD SKAPLTVVQS IDRGLLEREE AVRLLTKQVV DGGIIHHISG
2560 2570 2580 2590 2600
MRLSVDNAFR HGLIGEDLAE KLKRVENLNI HQIFNPETKE NISLPKAIKL
2610 2620 2630 2640 2650
DLITSDLKRE IQEVQAFTGN FVDLISGQRL TLAEAKKEGL LTNEAVLSPG
2660 2670 2680 2690 2700
MMHGIVDPEN CRIVPYSELV KKCKIDIESG QRYLEVIPFS DIKDGVSDKV
2710 2720 2730 2740 2750
LTLSQAIQLG KVDFASTLKV LEAQANTGGI IDTATGKRLT LASALEEKLV
2760 2770 2780 2790 2800
DENMVRIIAS HQVLNGGIVD IFSDQRVTLV EAIEKRLISP ELANMIQIDS
2810 2820 2830 2840 2850
SEFSDHRAQI EKQEGIEVCA LQNEFLGKDM LIACNQTAEM SCNKVEESER
2860 2870 2880 2890 2900
LFQVENQSAQ EKVKVRVSDG EQAKKSREIS LKEFGCKDQR KPRMSSDAKE
2910 2920 2930 2940 2950
FISIINPHNL KGKSLGQVSL THPYSECDFK LKEVARNNMG NDTNEEQEKA
2960 2970 2980 2990 3000
VTKIEIISHM KQSTSCLDSE EIRENQGEVI LEVQETYCET SGKLPSEQVL
3010 3020 3030 3040 3050
QQPMNARVKS KREKREVIVE ESIRTCKPAF LSEEKLYQET AIRDEHDSHI
3060 3070 3080 3090 3100
KSQPREMTSS EKGKEADTEM GFSITFKIEE SSSQVVPQGI SVKHLDALTL
3110 3120 3130 3140 3150
FSSKQANEGK VNNLSLCLTL KPEENLSREI ACGAQSEPFP CMTPRPEGLH
3160 3170 3180 3190 3200
YQESDGKAQV TGPSQISKTD KSFQGTTRQE TNYQDSWVTS KTKETKHQIS
3210 3220 3230 3240 3250
SSNECKEKSY QEVSFDPARG LKLEEITVSR PDSKEVRYLE FSDRKDLHHQ
3260 3270 3280 3290 3300
GSKSDDKLCG TLKSEIATQE LTGEKFLEMA NPNVAGLEAG SIEDIVTQRG
3310 3320 3330 3340 3350
SRVLGSFLPE KLFKGVSQKE NTGQQNAIIS PTVLETSEEK TVSLTVCSAV
3360 3370 3380 3390 3400
KTEKTPQEKL RESPGSEQTP FMTAPEGKGN GGVNPEPFRA TQNVFTRQLC
3410 3420 3430 3440 3450
LEHDEKLVSY LSLLRNIEMR TKQIQPLELN LAELQDLLCQ AKVLERELKD
3460 3470 3480 3490 3500
LTTLVSQELE CVNQIIISQP QEVPAQLLKA LEKDAKNLQK SLSSVSDTWN
3510 3520 3530 3540 3550
SRLLHFQNAV EIEKTKVLNQ HTQLEGRLQD LRAWVGNKNL ILNSKGSNSE
3560 3570 3580 3590 3600
IDVDSLNLCL QQYEDLKQPM AERKAQLDAL AFDIQFFISE HAQDLSPQQN
3610 3620 3630 3640 3650
RQMLRLLNEL QRSFQDILEQ TAAQVDALQG HLQQMEQEAL VKTLQKQQNT
3660 3670 3680 3690 3700
CHQQLEDLCS WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN
3710 3720 3730 3740 3750
RATSFATVVK DIEGFMEENQ TKLSPRELTA LREKLHQAKE QYEALQEETR
3760 3770 3780 3790 3800
VAQKELEEAV TSALQQETEK SKAAKELAEN KKKIDALLDW VTSVGSSGGQ
3810 3820 3830 3840 3850
LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ CEMMKARHQE
3860 3870 3880 3890 3900
LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA
3910 3920 3930 3940 3950
QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL
3960 3970 3980 3990 4000
PSLLKRQGSF SEDVISHKGD LRFVTISGQK VLDMENSFKE GKEPSEIGNL
4010 4020 4030 4040 4050
VKDKLKDATE RYTALHSKCT RLGSHLNMLL GQYHQFQNSA DSLQAWMQAC
4060 4070 4080 4090 4100
EANVEKLLSD TVASDPGVLQ EQLATTKQLQ EELAEHQVPV EKLQKVARDI
4110 4120 4130 4140 4150
MEIEGEPAPD HRHVQETTDS ILSHFQSLSY SLAERSSLLQ KAIAQSQSVQ
4160 4170 4180 4190 4200
ESLESLLQSI GEVEQNLEGK QVSSLSSGVI QEALATNMKL KQDIARQKSS
4210 4220 4230 4240 4250
LEATREMVTR FMETADSTTA AVLQGKLAEV SQRFEQLCLQ QQEKESSLKK
4260 4270 4280 4290 4300
LLPQAEMFEH LSGKLQQFME NKSRMLASGN QPDQDITHFF QQIQELNLEM
4310 4320 4330 4340 4350
EDQQENLDTL EHLVTELSSC GFALDLCQHQ DRVQNLRKDF TELQKTVKER
4360 4370 4380 4390 4400
EKDASSCQEQ LDEFRKLVRT FQKWLKETEG SIPPTETSMS AKELEKQIEH
4410 4420 4430 4440 4450
LKSLLDDWAS KGTLVEEINC KGTSLENLIM EITAPDSQGK TGSILPSVGS
4460 4470 4480 4490 4500
SVGSVNGYHT CKDLTEIQCD MSDVNLKYEK LGGVLHERQE SLQAILNRME
4510 4520 4530 4540 4550
EVHKEANSVL QWLESKEEVL KSMDAMSSPT KTETVKAQAE SNKAFLAELE
4560 4570 4580 4590 4600
QNSPKIQKVK EALAGLLVTY PNSQEAENWK KIQEELNSRW ERATEVTVAR
4610 4620 4630 4640 4650
QRQLEESASH LACFQAAESQ LRPWLMEKEL MMGVLGPLSI DPNMLNAQKQ
4660 4670 4680 4690 4700
QVQFMLKEFE ARRQQHEQLN EAAQGILTGP GDVSLSTSQV QKELQSINQK
4710 4720 4730 4740 4750
WVELTDKLNS RSSQIDQAIV KSTQYQELLQ DLSEKVRAVG QRLSVQSAIS
4760 4770 4780 4790 4800
TQPEAVKQQL EETSEIRSDL EQLDHEVKEA QTLCDELSVL IGEQYLKDEL
4810 4820 4830 4840 4850
KKRLETVALP LQGLEDLAAD RINRLQAALA STQQFQQMFD ELRTWLDDKQ
4860 4870 4880 4890 4900
SQQAKNCPIS AKLERLQSQL QENEEFQKSL NQHSGSYEVI VAEGESLLLS
4910 4920 4930 4940 4950
VPPGEEKRTL QNQLVELKNH WEELSKKTAD RQSRLKDCMQ KAQKYQWHVE
4960 4970 4980 4990 5000
DLVPWIEDCK AKMSELRVTL DPVQLESSLL RSKAMLNEVE KRRSLLEILN
5010 5020 5030 5040 5050
SAADILINSS EADEDGIRDE KAGINQNMDA VTEELQAKTG SLEEMTQRLR
5060 5070 5080 5090 5100
EFQESFKNIE KKVEGAKHQL EIFDALGSQA CSNKNLEKLR AQQEVLQALE
5110 5120 5130 5140 5150
PQVDYLRNFT QGLVEDAPDG SDASQLLHQA EVAQQEFLEV KQRVNSGCVM
5160 5170 5180 5190 5200
MENKLEGIGQ FHCRVREMFS QLADLDDELD GMGAIGRDTD SLQSQIEDVR
5210 5220 5230 5240 5250
LFLNKIHVLK LDIEASEAEC RHMLEEEGTL DLLGLKRELE ALNKQCGKLT
5260 5270 5280 5290 5300
ERGKARQEQL ELTLGRVEDF YRKLKGLNDA TTAAEEAEAL QWVVGTEVEI
5310 5320 5330 5340 5350
INQQLADFKM FQKEQVDPLQ MKLQQVNGLG QGLIQSAGKD CDVQGLEHDM
5360 5370 5380 5390 5400
EEINARWNTL NKKVAQRIAQ LQEALLHCGK FQDALEPLLS WLADTEELIA
5410 5420 5430 5440 5450
NQKPPSAEYK VVKAQIQEQK LLQRLLDDRK ATVDMLQAEG GRIAQSAELA
5460 5470 5480 5490 5500
DREKITGQLE SLESRWTELL SKAAARQKQL EDILVLAKQF HETAEPISDF
5510 5520 5530 5540 5550
LSVTEKKLAN SEPVGTQTAK IQQQIIRHKA LEEDIENHAT DVHQAVKIGQ
5560 5570 5580 5590 5600
SLSSLTSPAE QGVLSEKIDS LQARYSEIQD RCCRKAALLD QALSNARLFG
5610 5620 5630 5640 5650
EDEVEVLNWL AEVEDKLSSV FVKDFKQDVL HRQHADHLAL NEEIVNRKKN
5660 5670 5680 5690 5700
VDQAIKNGQA LLKQTTGEEV LLIQEKLDGI KTRYADITVT SSKALRTLEQ
5710 5720 5730 5740 5750
ARQLATKFQS TYEELTGWLR EVEEELATSG GQSPTGEQIP QFQQRQKELK
5760 5770 5780 5790 5800
KEVMEHRLVL DTVNEVSRAL LELVPWRARE GLDKLVSDAN EQYKLVSDTI
5810 5820 5830 5840 5850
GQRVDEIDAA IQRSQQYEQA ADAELAWVAE TKRKLMALGP IRLEQDQTTA
5860 5870 5880 5890 5900
QLQVQKAFSI DIIRHKDSMD ELFSHRSEIF GTCGEEQKTV LQEKTESLIQ
5910 5920 5930 5940 5950
QYEAISLLNS ERYARLERAQ VLVNQFWETY EELSPWIEET RALIAQLPSP
5960 5970 5980 5990 6000
AIDHEQLRQQ QEEMRQLRES IAEHKPHIDK LLKIGPQLKE LNPEEGEMVE
6010 6020 6030 6040 6050
EKYQKAENMY AQIKEEVRQR ALALDEAVSQ STQFHDKIEP MLETLENLSS
6060 6070 6080 6090 6100
RLRMPPLIPA EVDKIRECIS DNKSATVELE KLQPSFEALK RRGEELIGRS
6110 6120 6130 6140 6150
QGADKDLAAK EIQDKLDQMV FFWEDIKARA EEREIKFLDV LELAEKFWYD
6160 6170 6180 6190 6200
MAALLTTIKD TQDIVHDLES PGIDPSIIKQ QVEAAETIKE ETDGLHEELE
6210 6220 6230 6240 6250
FIRILGADLI FACGETEKPE VRKSIDEMNN AWENLNKTWK ERLEKLEDAM
6260 6270 6280 6290 6300
QAAVQYQDTL QAMFDWLDNT VIKLCTMPPV GTDLNTVKDQ LNEMKEFKVE
6310 6320 6330 6340 6350
VYQQQIEMEK LNHQGELMLK KATDETDRDI IREPLTELKH LWENLGEKIA
6360 6370 6380 6390 6400
HRQHKLEGAL LALGQFQHAL EELMSWLTHT EELLDAQRPI SGDPKVIEVE
6410 6420 6430 6440 6450
LAKHHVLKND VLAHQATVET VNKAGNELLE SSAGDDASSL RSRLEAMNQC
6460 6470 6480 6490 6500
WESVLQKTEE REQQLQSTLQ QAQGFHSEIE DFLLELTRME SQLSASKPTG
6510 6520 6530 6540 6550
GLPETAREQL DTHMELYSQL KAKEETYNQL LDKGRLMLLS RDDSGSGSKT
6560 6570 6580 6590 6600
EQSVALLEQK WHVVSSKMEE RKSKLEEALN LATEFQNSLQ EFINWLTLAE
6610 6620 6630 6640 6650
QSLNIASPPS LILNTVLSQI EEHKVFANEV NAHRDQIIEL DQTGNQLKFL
6660 6670 6680 6690 6700
SQKQDVVLIK NLLVSVQSRW EKVVQRSIER GRSLDDARKR AKQFHEAWKK
6710 6720 6730 6740 6750
LIDWLEDAES HLDSELEISN DPDKIKLQLS KHKEFQKTLG GKQPVYDTTI
6760 6770 6780 6790 6800
RTGRALKEKT LLPEDSQKLD NFLGEVRDKW DTVCGKSVER QHKLEEALLF
6810 6820 6830 6840 6850
SGQFMDALQA LVDWLYKVEP QLAEDQPVHG DLDLVMNLMD AHKVFQKELG
6860 6870 6880 6890 6900
KRTGTVQVLK RSGRELIENS RDDTTWVKGQ LQELSTRWDT VCKLSVSKQS
6910 6920 6930 6940 6950
RLEQALKQAE VFRDTVHMLL EWLSEAEQTL RFRGALPDDT EALQSLIDTH
6960 6970 6980 6990 7000
KEFMKKVEEK RVDVNSAVAM GEVILAVCHP DCITTIKHWI TIIRARFEEV
7010 7020 7030 7040 7050
LTWAKQHQQR LETALSELVA NAELLEELLA WIQWAETTLI QRDQEPIPQN
7060 7070 7080 7090 7100
IDRVKALIAE HQTFMEEMTR KQPDVDRVTK TYKRKNIEPT HAPFIEKSRS
7110 7120 7130 7140 7150
GGRKSLSQPT PPPMPILSQS EAKNPRINQL SARWQQVWLL ALERQRKLND
7160 7170 7180 7190 7200
ALDRLEELKE FANFDFDVWR KKYMRWMNHK KSRVMDFFRR IDKDQDGKIT
7210 7220 7230 7240 7250
RQEFIDGILA SKFPTTKLEM TAVADIFDRD GDGYIDYYEF VAALHPNKDA
7260 7270 7280 7290 7300
YRPTTDADKI EDEVTRQVAQ CKCAKRFQVE QIGENKYRFF LGNQFGDSQQ
7310 7320 7330 7340 7350
LRLVRILRST VMVRVGGGWM ALDEFLVKND PCRVHHPGSK IKRSDSSSSI
7360 7370 7380 7390 7400
SSQSPIARGR TNIELREKFI LPEGASQGMT PFRSRGRRSK PSSRAASPTR
7410 7420 7430 7440 7450
SSSSASQSNH SCTSMPSSPA TPASGTKTSL QFSRCYDKPW LVNSKAGTPI
7460 7470 7480 7490 7500
RDSHSPDLQL PTPEVIPSSG SKLKRPTPTF HSSRTSLAGD TSNSSSPAST
7510 7520 7530 7540 7550
GAKTNRADPK KSASRPGSRA GSRAGSRASS RRGSDASDFD LLETQSACSD
7560 7570 7580 7590
TSESSAAGGQ GNSRRGLNKP SKIPTMSKKT TTASPRTPGP KR
Length:7,592
Mass (Da):861,078
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2189899D37DA6FAC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJG2A0A590UJG2_HUMAN
Microtubule-actin cross-linking fac...
MACF1
5,379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0MQR8A0A7P0MQR8_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX0A0A5F9ZGX0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000567887; ENSP00000455823; ENSG00000127603

UCSC genome browser

More...
UCSCi
uc057ezv.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

SMRiH3BQK9
ModBaseiSearch...

Protein-protein interaction databases

IntActiH3BQK9, 1 interactor

Proteomic databases

MaxQBiH3BQK9
PeptideAtlasiH3BQK9
PRIDEiH3BQK9
ProteomicsDBi41815

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31853, 66 antibodies from 18 providers

Genome annotation databases

EnsembliENST00000567887; ENSP00000455823; ENSG00000127603
UCSCiuc057ezv.1, human

Organism-specific databases

HGNCiHGNC:13664, MACF1
OpenTargetsiENSG00000127603
VEuPathDBiHostDB:ENSG00000127603

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_0_1_1
OMAiVIKLCEM
PhylomeDBiH3BQK9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MACF1, human

Gene expression databases

BgeeiENSG00000127603, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiH3BQK9, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 20 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BQK9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BQK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 19, 2022
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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