UniProtKB - H3BQK2 (H3BQK2_HUMAN)
Protein
Poly [ADP-ribose] polymerase
Gene
PARP6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- NAD+ ADP-ribosyltransferase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Ligand | NADUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.-UniRule annotation)Short name: PARPUniRule annotation |
Gene namesi | Name:PARP6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26921 PARP6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137817 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland |
ExpressionAtlasi | H3BQK2 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 327 – 554 | PARP catalyticInterPro annotationAdd BLAST | 228 |
Phylogenomic databases
eggNOGi | ENOG410IE5T Eukaryota ENOG410ZI9J LUCA |
GeneTreei | ENSGT00950000183129 |
Family and domain databases
InterProi | View protein in InterPro IPR012317 Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF00644 PARP, 1 hit |
PROSITEi | View protein in PROSITE PS51059 PARP_CATALYTIC, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
H3BQK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XEIYSENSVS IREYGTIDDV DIDLHINISF LDEEVSTAWK VLRTEPIVLR
60 70 80 90 100
LRFSLSQYLD GPEPSIEVFQ PSNKEGFGLG LQLKKILGMF TSQQWKHLSN
110 120 130 140 150
DFLKTQQEKR HSWFKASGTI KKFRAGLSIF SPIPKSPSFP IIQDSMLKGK
160 170 180 190 200
LGVPELRVGR LMNRSISCTM KNPKVEVFGY PPSPQVSGHC KNIPTLEYGF
210 220 230 240 250
LVQIMKYAEQ RIPTLNEYCV VCDEQHVFQN GSMLKPAVCT RELCVFSFYT
260 270 280 290 300
LGVMSGAAEE VATGAEVVDL LVAMCRAALE SPRKSIIFEP YPSVVDPTDP
310 320 330 340 350
KTLAFNPKKK NYERLQKALD SVMSIREMTQ GSYLEIKKQM DKLDPLAHPL
360 370 380 390 400
LQWIISSNRS HIVKLPLSRQ LKFMHTSHQF LLLSSPPAKE ARFRTAKKLY
410 420 430 440 450
GSTFAFHGSH IENWHSILRN GLVNASYTKL QLHGAAYGKG IYLSPISSIS
460 470 480 490 500
FGYSGMGKGQ HRMPSKDELV QRYNRMNTIP QTRSIQSRFL QSRNLNCIAL
510 520 530 540 550
CEVITSKDLQ KHGNIWVCPV SDHVCTRFFF VYEDGQVGDA NINTQDPKIQ
560
KEIMRVIGTQ VYTN
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ2NL67 | PARP6_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 630 | Annotation score: | ||
F5H3B4 | F5H3B4_HUMAN | Poly [ADP-ribose] polymerase | PARP6 | 553 | Annotation score: | ||
H3BQM7 | H3BQM7_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 73 | Annotation score: | ||
H3BUQ6 | H3BUQ6_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 124 | Annotation score: | ||
H3BRR4 | H3BRR4_HUMAN | Poly (ADP-ribose) polymerase family... | PARP6 hCG_40464 | 519 | Annotation score: | ||
H3BRZ3 | H3BRZ3_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 451 | Annotation score: | ||
H3BTI3 | H3BTI3_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 26 | Annotation score: | ||
H3BSK7 | H3BSK7_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 80 | Annotation score: | ||
H3BTE2 | H3BTE2_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 76 | Annotation score: | ||
H3BUY2 | H3BUY2_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 73 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009690 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000567974; ENSP00000455815; ENSG00000137817 |
UCSCi | uc059lam.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009690 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
EPDi | H3BQK2 |
PRIDEi | H3BQK2 |
ProteomicsDBi | 41809 |
Genome annotation databases
Ensembli | ENST00000567974; ENSP00000455815; ENSG00000137817 |
UCSCi | uc059lam.1 human |
Organism-specific databases
HGNCi | HGNC:26921 PARP6 |
OpenTargetsi | ENSG00000137817 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IE5T Eukaryota ENOG410ZI9J LUCA |
GeneTreei | ENSGT00950000183129 |
Miscellaneous databases
ChiTaRSi | PARP6 human |
Gene expression databases
Bgeei | ENSG00000137817 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland |
ExpressionAtlasi | H3BQK2 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR012317 Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF00644 PARP, 1 hit |
PROSITEi | View protein in PROSITE PS51059 PARP_CATALYTIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BQK2_HUMAN | |
Accessioni | H3BQK2Primary (citable) accession number: H3BQK2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | July 31, 2019 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |