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Entry version 41 (05 Dec 2018)
Sequence version 2 (29 Oct 2014)
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Protein
Submitted name:

Obscurin

Gene

OBSCN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ObscurinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OBSCNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000154358.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15719 OBSCN

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000154358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H3BQA7

PeptideAtlas

More...
PeptideAtlasi
H3BQA7

PRoteomics IDEntifications database

More...
PRIDEi
H3BQA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154358 Expressed in 135 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H3BQA7 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
H3BQA7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 184Ig-likeInterPro annotationAdd BLAST83
Domaini196 – 275Ig-likeInterPro annotationAdd BLAST80
Domaini371 – 445Ig-likeInterPro annotationAdd BLAST75
Domaini460 – 544Ig-likeInterPro annotationAdd BLAST85
Domaini549 – 632Ig-likeInterPro annotationAdd BLAST84
Domaini635 – 720Ig-likeInterPro annotationAdd BLAST86
Domaini725 – 808Ig-likeInterPro annotationAdd BLAST84
Domaini813 – 896Ig-likeInterPro annotationAdd BLAST84
Domaini901 – 984Ig-likeInterPro annotationAdd BLAST84
Domaini989 – 1072Ig-likeInterPro annotationAdd BLAST84
Domaini1077 – 1160Ig-likeInterPro annotationAdd BLAST84
Domaini1165 – 1248Ig-likeInterPro annotationAdd BLAST84
Domaini1253 – 1336Ig-likeInterPro annotationAdd BLAST84
Domaini1341 – 1424Ig-likeInterPro annotationAdd BLAST84
Domaini1429 – 1512Ig-likeInterPro annotationAdd BLAST84

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG0613 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154756

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 18 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 18 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H3BQA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XRARVRVHDL HVGITKRLKT MEVLEGESCS FECVLSHESA SDPAMWTVGG
60 70 80 90 100
KTVGSSSRFQ ATRQGRKYIL VVREAAPSDA GEVVFSVRGL TSKASLIVRE
110 120 130 140 150
RPAAIIKPLE DQWVAPGEDV ELRCELSRAG TPVHWLKDRK AIRKSQKYDV
160 170 180 190 200
VCEGTMAMLV IRGASLKDAG EYTCEVEASK STASLHVEEK ANCFTEELTN
210 220 230 240 250
LQVEEKGTAV FTCKTEHPAA TVTWRKGLLE LRASGKHQPS QEGLTLRLTI
260 270 280 290 300
SALEKADSDT YTCDIGQAQS RAQLLVQGRR VHIIEDLEDV DVQEGSSATF
310 320 330 340 350
RCRISPANYE PVHWFLDKTP LHANELNEID AQPGGYHVLT LRQLALKDSG
360 370 380 390 400
TIYFEAGDQR ASAALRVTEK PSVFSRELTD ATITEGEDLT LVCETSTCDI
410 420 430 440 450
PVCWTKDGKT LRGSARCQLS HEGHRAQLLI TGATLQDSGR YKCEAGGACS
460 470 480 490 500
SSIVRVHARP VRFQEALKDL EVLEGGAATL RCVLSSVAAP VKWCYGNNVL
510 520 530 540 550
RPGDKYSLRQ EGAMLELVVR NLRPQDSGRY SCSFGDQTTS ATLTVTALPA
560 570 580 590 600
QFIGKLRNKE ATEGATATLR CELSKAAPVE WRKGSETLRD GDRYCLRQDG
610 620 630 640 650
AMCELQIRGL AMVDAAEYSC VCGEERTSAS LTIRPMPAHF IGRLRHQESI
660 670 680 690 700
EGATATLRCE LSKAAPVEWR KGRESLRDGD RHSLRQDGAV CELQICGLAV
710 720 730 740 750
ADAGEYSCVC GEERTSATLT VKALPAKFTE GLRNEEAVEG ATAMLWCELS
760 770 780 790 800
KVAPVEWRKG PENLRDGDRY ILRQEGTRCE LQICGLAMAD AGEYLCVCGQ
810 820 830 840 850
ERTSATLTIR ALPARFIEDV KNQEAREGAT AVLQCELNSA APVEWRKGSE
860 870 880 890 900
TLRDGDRYSL RQDGTKCELQ IRGLAMADTG EYSCVCGQER TSAMLTVRAL
910 920 930 940 950
PIKFTEGLRN EEATEGATAV LRCELSKMAP VEWWKGHETL RDGDRHSLRQ
960 970 980 990 1000
DGARCELQIR GLVAEDAGEY LCMCGKERTS AMLTVRAMPS KFIEGLRNEE
1010 1020 1030 1040 1050
ATEGDTATLW CELSKAAPVE WRKGHETLRD GDRHSLRQDG SRCELQIRGL
1060 1070 1080 1090 1100
AVVDAGEYSC VCGQERTSAT LTVRALPARF IEDVKNQEAR EGATAVLQCE
1110 1120 1130 1140 1150
LSKAAPVEWR KGSETLRGGD RYSLRQDGTR CELQIHGLSV ADTGEYSCVC
1160 1170 1180 1190 1200
GQERTSATLT VRALPARFTQ DLKTKEASEG ATATLQCELS KVAPVEWKKG
1210 1220 1230 1240 1250
PETLRDGGRY SLKQDGTRCE LQIHDLSVAD AGEYSCMCGQ ERTSATLTVR
1260 1270 1280 1290 1300
ALPARFTEGL RNEEAMEGAT ATLQCELSKA APVEWRKGLE ALRDGDKYSL
1310 1320 1330 1340 1350
RQDGAVCELQ IHGLAMADNG VYSCVCGQER TSATLTVRAL PARFIEDMRN
1360 1370 1380 1390 1400
QKATEGATVT LQCKLRKAAP VEWRKGPNTL KDGDRYSLKQ DGTSCELQIR
1410 1420 1430 1440 1450
GLVIADAGEY SCICEQERTS ATLTVRALPA RFIEDVRNHE ATEGATAVLQ
1460 1470 1480 1490 1500
CELSKAAPVE WRKGSETLRD GDRYSLRQDG TRCELQIRGL AVEDTGEYLC
1510 1520 1530 1540 1550
VCGQERTSAT LTVRALPARF IDNMTNQEAR EGATATLHCE LSKVAPVEWR
1560 1570 1580 1590
KGPETLRDGD RHSLRQENCL NPGGRGCSEP RSCHCTPAWV IEQ
Length:1,593
Mass (Da):175,129
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6EB6B4A4FDBB3B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VST9OBSCN_HUMAN
Obscurin
OBSCN KIAA1556, KIAA1639
7,968Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NGQ3A6NGQ3_HUMAN
Obscurin
OBSCN
8,923Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTS2A0A1B0GTS2_HUMAN
Obscurin
OBSCN
2,585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRI8A0A0A0MRI8_HUMAN
Obscurin
OBSCN
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPW6H3BPW6_HUMAN
Obscurin
OBSCN
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1593Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000483539; ENSP00000455688; ENSG00000154358

UCSC genome browser

More...
UCSCi
uc057qeh.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353593 Genomic DNA No translation available.
AL359510 Genomic DNA No translation available.
AL670729 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH3BQA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000455507

Proteomic databases

PaxDbiH3BQA7
PeptideAtlasiH3BQA7
PRIDEiH3BQA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000483539; ENSP00000455688; ENSG00000154358
UCSCiuc057qeh.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000154358.19
HGNCiHGNC:15719 OBSCN
OpenTargetsiENSG00000154358

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG0613 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00940000154756

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OBSCN human

Gene expression databases

BgeeiENSG00000154358 Expressed in 135 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiH3BQA7 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 18 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 17 hits
SMARTiView protein in SMART
SM00409 IG, 17 hits
SM00408 IGc2, 16 hits
SUPFAMiSSF48726 SSF48726, 18 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BQA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BQA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 29, 2014
Last modified: December 5, 2018
This is version 41 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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