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Entry version 67 (11 Dec 2019)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7155 – 7166PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7191 – 7202PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127603.23

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13664 MACF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
H3BPE1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H3BPE1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H3BPE1

PeptideAtlas

More...
PeptideAtlasi
H3BPE1

PRoteomics IDEntifications database

More...
PRIDEi
H3BPE1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
41466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127603 Expressed in 240 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H3BPE1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
H3BPE1, 15 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 176Calponin-homology (CH)InterPro annotationAdd BLAST136
Domaini189 – 293Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini863 – 920SH3InterPro annotationAdd BLAST58
Domaini7142 – 7177EF-handInterPro annotationAdd BLAST36
Domaini7178 – 7213EF-handInterPro annotationAdd BLAST36
Domaini7218 – 7296GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2046 – 2087DisorderedSequence analysisAdd BLAST42
Regioni3008 – 3029DisorderedSequence analysisAdd BLAST22
Regioni3099 – 3169DisorderedSequence analysisAdd BLAST71
Regioni3316 – 3345DisorderedSequence analysisAdd BLAST30
Regioni5687 – 5707DisorderedSequence analysisAdd BLAST21
Regioni7052 – 7082DisorderedSequence analysisAdd BLAST31
Regioni7299 – 7390DisorderedSequence analysisAdd BLAST92
Regioni7410 – 7555DisorderedSequence analysisAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21
Coiled coili472 – 492Sequence analysisAdd BLAST21
Coiled coili497 – 524Sequence analysisAdd BLAST28
Coiled coili816 – 836Sequence analysisAdd BLAST21
Coiled coili1041 – 1061Sequence analysisAdd BLAST21
Coiled coili1398 – 1428Sequence analysisAdd BLAST31
Coiled coili1492 – 1512Sequence analysisAdd BLAST21
Coiled coili1517 – 1537Sequence analysisAdd BLAST21
Coiled coili3390 – 3417Sequence analysisAdd BLAST28
Coiled coili3441 – 3461Sequence analysisAdd BLAST21
Coiled coili3563 – 3601Sequence analysisAdd BLAST39
Coiled coili3691 – 3725Sequence analysisAdd BLAST35
Coiled coili3855 – 3885Sequence analysisAdd BLAST31
Coiled coili4249 – 4276Sequence analysisAdd BLAST28
Coiled coili4296 – 4316Sequence analysisAdd BLAST21
Coiled coili4354 – 4374Sequence analysisAdd BLAST21
Coiled coili4459 – 4479Sequence analysisAdd BLAST21
Coiled coili4619 – 4639Sequence analysisAdd BLAST21
Coiled coili4678 – 4698Sequence analysisAdd BLAST21
Coiled coili4719 – 4753Sequence analysisAdd BLAST35
Coiled coili4870 – 4890Sequence analysisAdd BLAST21
Coiled coili4991 – 5032Sequence analysisAdd BLAST42
Coiled coili5195 – 5215Sequence analysisAdd BLAST21
Coiled coili5306 – 5326Sequence analysisAdd BLAST21
Coiled coili5959 – 5979Sequence analysisAdd BLAST21
Coiled coili6192 – 6219Sequence analysisAdd BLAST28
Coiled coili6404 – 6424Sequence analysisAdd BLAST21
Coiled coili6971 – 6991Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2048 – 2071PolyampholyteSequence analysisAdd BLAST24
Compositional biasi3120 – 3159PolarSequence analysisAdd BLAST40
Compositional biasi5691 – 5706PolarSequence analysisAdd BLAST16
Compositional biasi7306 – 7322PolarSequence analysisAdd BLAST17
Compositional biasi7354 – 7390PolarSequence analysisAdd BLAST37
Compositional biasi7425 – 7470PolarSequence analysisAdd BLAST46
Compositional biasi7502 – 7555PolarSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

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CDDi
cd00014 CH, 2 hits
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 1 hit
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF24 PTHR23169:SF24, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 9 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 17 hits
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 20 hits
SM00150 SPEC, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

H3BPE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLDSSYLP PTIFILTHVL GVAGVLYWKR HARGRADERD RVQKKTFTKW
60 70 80 90 100
VNKHLMKVRK HINDLYEDLR DGHNLISLLE VLSGIKLEPA GLKTLRLVSM
110 120 130 140 150
PSWCHTNNEE QAEEDDDDVP REKGRMRFHR LQNVQIALDF LKQRQVKLVN
160 170 180 190 200
IRNDDITDGN PKLTLGLIWT IILHFQISDI YISGESGDMS AKEKLLLWTQ
210 220 230 240 250
KVTAGYTGIK CTNFSSCWSD GKMFNALIHR YRPDLVDMER VQIQSNRENL
260 270 280 290 300
EQAFEVAERL GVTRLLDAED VDVPSPDEKS VITYVSSIYD AFPKVPEGGE
310 320 330 340 350
GISATEVDSR WQEYQSRVDS LIPWIKQHTI LMSDKTFPQN PVELKALYNQ
360 370 380 390 400
YIHFKETEIL AKEREKGRIE ELYKLLEVWI EFGRIKLPQG YHPNDVEEEW
410 420 430 440 450
GKLIIEMLER EKSLRPAVER LELLLQIANK IQNGALNCEE KLTLAKNTLQ
460 470 480 490 500
ADAAHLESGQ PVQCESDVIM YIQECEGLIR QLQVDLQILR DENYYQLEEL
510 520 530 540 550
AFRVMRLQDE LVTLRLECTN LYRKGHFTSL ELVPPSTLTT THLKAEPLTK
560 570 580 590 600
ATHSSSTSWF RKPMTRAELV AISSSEDEGN LRFVYELLSW VEEMQMKLER
610 620 630 640 650
AEWGNDLPSV ELQLETQQHI HTSVEELGSS VKEARLYEGK MSQNFHTSYA
660 670 680 690 700
ETLGKLETQY CKLKETSSFR MRHLQSLHKF VSRATAELIW LNEKEEEELA
710 720 730 740 750
YDWSDNNSNI SAKRNYFSEL TMELEEKQDV FRSLQDTAEL LSLENHPAKQ
760 770 780 790 800
TVEAYSAAVQ SQLQWMKQLC LCVEQHVKEN TAYFQFFSDA RELESFLRNL
810 820 830 840 850
QDSIKRKYSC DHNTSLSRLE DLLQDSMDEK EQLIQSKSSV ASLVGRSKTI
860 870 880 890 900
VQLKPRSPDH VLKNTISVKA VCDYRQIEIT ICKNDECVLE DNSQRTKWKV
910 920 930 940 950
ISPTGNEAMV PSVCFLIPPP NKDAIEMASR VEQSYQKVMA LWHQLHVNTK
960 970 980 990 1000
SLISWNYLRK DLDLVQTWNL EKLRSSAPGE CHQIMKNLQA HYEDFLQDSR
1010 1020 1030 1040 1050
DSVLFSVADR LRLEEEVEAC KARFQHLMKS MENEDKEETV AKMYISELKN
1060 1070 1080 1090 1100
IRLRLEEYEQ RVVKRIQSLA SSRTDRDAWQ DNALRIAEQE HTQEDLQQLR
1110 1120 1130 1140 1150
SDLDAVSMKC DSFLHQSPSS SSVPTLRSEL NLLVEKMDHV YGLSTVYLNK
1160 1170 1180 1190 1200
LKTVDVIVRS IQDAELLVKG YEIKLSQEEV VLADLSALEA HWSTLRHWLS
1210 1220 1230 1240 1250
DVKDKNSVFS VLDEEIAKAK VVAEQMSRLT PERNLDLERY QEKGSQLQER
1260 1270 1280 1290 1300
WHRVIAQLEI RQSELESIQE VLGDYRACHG TLIKWIEETT AQQEMMKPGQ
1310 1320 1330 1340 1350
AEDSRVLSEQ LSQQTALFAE IERNQTKLDQ CQKFSQQYST IVKDYELQLM
1360 1370 1380 1390 1400
TYKAFVESQQ KSPGKRRRML SSSDAITQEF MDLRTRYTAL VTLTTQHVKY
1410 1420 1430 1440 1450
ISDALRRLEE EEKVVEEEKQ EHVEKVKELL GWVSTLARNT QGKATSSETK
1460 1470 1480 1490 1500
ESTDIEKAIL EQQVLSEELT TKKEQVSEAI KTSQIFLAKH GHKLSEKEKK
1510 1520 1530 1540 1550
QISEQLNALN KAYHDLCDGS ANQLQQLQSQ LAHQTEQKEC RAVAGVIDLG
1560 1570 1580 1590 1600
TVEIFPIFKA MQKGLLDQDT GLVLLESQVI MSGLIAPETG ENLSLEEGIA
1610 1620 1630 1640 1650
RNLINPQMYQ QLRELQDALA LISRLTESRG PLSVVEAIEK RIISETVGLK
1660 1670 1680 1690 1700
ILEAHLATGG FSLSPSENCI NLEEAFHQGL ISAWLHSVLE SYLRTSKNLI
1710 1720 1730 1740 1750
DPNTAEKIGL LDLMQRCIVH QESGFKLLPV KQLAGGMVSL KSGRKVSIFR
1760 1770 1780 1790 1800
AVQEGLIDRQ VTVRLLEAQL FAGGIVDPRT GHRLTVEEAV RHNLIDQDMA
1810 1820 1830 1840 1850
CAILIRQLQT GGIIDTVTGQ RLTIDEAVSN DLVAAKIALV ILESLWSFMG
1860 1870 1880 1890 1900
LLWPESGEIL PITDALEQGI VSTELAHKIL SNRQHIKALF LPATTEILSW
1910 1920 1930 1940 1950
KKAIESGILD RDLANNLKSI CIPDVMPHMQ LADSAEQNIN PGAAVLPCSK
1960 1970 1980 1990 2000
SHPKATASQS ENLLFQLMTH SYINVQNGQR LLLLDKELME TLTSRDEYQT
2010 2020 2030 2040 2050
SPPKVVEIGH QRQKTPEGLQ ESANVKISGT FSSGWTVRLP EFQFSSQNKE
2060 2070 2080 2090 2100
YPDREDCTTE KGKKTTVETE DSSVENPEQD LFVEQKERNP NIDALKVINK
2110 2120 2130 2140 2150
VKLEVQRQLI GTQREDQTAV SVRENASRGH LLTIPPAEAE GVPLVVDKDV
2160 2170 2180 2190 2200
FSVETPKKEH QPLRNTSFTC QNEQAHTLET EYIHDETGGS HIKPQSKKLQ
2210 2220 2230 2240 2250
VQVKKTLGIK LELKSETDGN VHPLDKKEML KKTFLAKDDH KESQEAQNIA
2260 2270 2280 2290 2300
GGSMMMSEKT DEEDSGREIF LSCSHPLELL EEATLNVLSA QLLDGGIFHE
2310 2320 2330 2340 2350
QTGQKLLLNE AISRGIVPSH TAVKLMEKLN MFQGFFDSQT CESLTTEEVI
2360 2370 2380 2390 2400
NEGLMDEKLL HNVLMADKAI SGVLDPRTQT LCSVKDAVTV GLLDKETATR
2410 2420 2430 2440 2450
ILERQVVTGG IIDLKRGKKV SVTLASTLGL VDVADQPELI NLEKASKGRD
2460 2470 2480 2490 2500
AEKTVRERLI SLQMETTGLI DPDSKAPLTV VQSIDRGLLE REEAVRLLTK
2510 2520 2530 2540 2550
QVVDGGIIHH ISGMRLSVDN AFRHGLIGED LAEKLKRVEN LNIHQIFNPE
2560 2570 2580 2590 2600
TKENISLPKA IKLDLITSDL KREIQEVQAF TGNFVDLISG QRLTLAEAKK
2610 2620 2630 2640 2650
EGLLTNEAVL SPGMMHGIVD PENCRIVPYS ELVKKCKIDI ESGQRYLEVI
2660 2670 2680 2690 2700
PFSDIKDGVS DKVLTLSQAI QLGKVDFAST LKVLEAQANT GGIIDTATGK
2710 2720 2730 2740 2750
RLTLASALEE KLVDENMVRI IASHQVLNGG IVDIFSDQRV TLVEAIEKRL
2760 2770 2780 2790 2800
ISPELANMIQ IDSSEFSDHR AQIEKQEGIE VCALQNEFLG KDMLIACNQT
2810 2820 2830 2840 2850
AEMSCNKVEE SERLFQVENQ SAQEKVKVRV SDGEQAKKSR EISLKEFGCK
2860 2870 2880 2890 2900
DQRKPRMSSD AKEFISIINP HNLKGKSLGQ VSLTHPYSEC DFKLKEVARN
2910 2920 2930 2940 2950
NMGNDTNEEQ EKAVTKIEII SHMKQSTSCL DSEEIRENQG EVILEVQETY
2960 2970 2980 2990 3000
CETSGKLPSE QVLQQPMNAR VKSKREKREV IVEESIRTCK PAFLSEEKLY
3010 3020 3030 3040 3050
QETAIRDEHD SHIKSQPREM TSSEKGKEAD TEMGFSITFK IEESSSQVVP
3060 3070 3080 3090 3100
QGISVKHLDA LTLFSSKQAN EGKVNNLSLC LTLKPEENLS REIACGAQSE
3110 3120 3130 3140 3150
PFPCMTPRPE GLHYQESDGK AQVTGPSQIS KTDKSFQGTT RQETNYQDSW
3160 3170 3180 3190 3200
VTSKTKETKH QISSSNECKE KSYQEVSFDP ARGLKLEEIT VSRPDSKEVR
3210 3220 3230 3240 3250
YLEFSDRKDL HHQGSKSDDK LCGTLKSEIA TQELTGEKFL EMANPNVAGL
3260 3270 3280 3290 3300
EAGSIEDIVT QRGSRVLGSF LPEKLFKGVS QKENTGQQNA IISPTVLETS
3310 3320 3330 3340 3350
EEKTVSLTVC SAVKTEKTPQ EKLRESPGSE QTPFMTAPEG KGNGGVNPEP
3360 3370 3380 3390 3400
FRATQNVFTR QLCLEHDEKL VSYLSLLRNI EMRTKQIQPL ELNLAELQDL
3410 3420 3430 3440 3450
LCQAKVLERE LKDLTTLVSQ ELECVNQIII SQPQEVPAQL LKALEKDAKN
3460 3470 3480 3490 3500
LQKSLSSVSD TWNSRLLHFQ NAVEIEKTKV LNQHTQLEGR LQDLRAWVGN
3510 3520 3530 3540 3550
KNLILNSKGS NSEIDVDSLN LCLQQYEDLK QPMAERKAQL DALAFDIQFF
3560 3570 3580 3590 3600
ISEHAQDLSP QQNRQMLRLL NELQRSFQDI LEQTAAQVDA LQGHLQQMEQ
3610 3620 3630 3640 3650
EALVKTLQKQ QNTCHQQLED LCSWVGQAER ALAGHQGRTT QQDLSALQKN
3660 3670 3680 3690 3700
QSDLKDLQDD IQNRATSFAT VVKDIEGFME ENQTKLSPRE LTALREKLHQ
3710 3720 3730 3740 3750
AKEQYEALQE ETRVAQKELE EAVTSALQQE TEKSKAAKEL AENKKKIDAL
3760 3770 3780 3790 3800
LDWVTSVGSS GGQLLTNLPG MEQLSGASLE KGALDTTDGY MGVNQAPEKL
3810 3820 3830 3840 3850
DKQCEMMKAR HQELLSQQQN FILATQSAQA FLDQHGHNLT PEEQQMLQQK
3860 3870 3880 3890 3900
LGELKEQYST SLAQSEAELK QVQTLQDELQ KFLQDHKEFE SWLERSEKEL
3910 3920 3930 3940 3950
ENMHKGGSSP ETLPSLLKRQ GSFSEDVISH KGDLRFVTIS GQKVLDMENS
3960 3970 3980 3990 4000
FKEGKEPSEI GNLVKDKLKD ATERYTALHS KCTRLGSHLN MLLGQYHQFQ
4010 4020 4030 4040 4050
NSADSLQAWM QACEANVEKL LSDTVASDPG VLQEQLATTK QLQEELAEHQ
4060 4070 4080 4090 4100
VPVEKLQKVA RDIMEIEGEP APDHRHVQET TDSILSHFQS LSYSLAERSS
4110 4120 4130 4140 4150
LLQKAIAQSQ SVQESLESLL QSIGEVEQNL EGKQVSSLSS GVIQEALATN
4160 4170 4180 4190 4200
MKLKQDIARQ KSSLEATREM VTRFMETADS TTAAVLQGKL AEVSQRFEQL
4210 4220 4230 4240 4250
CLQQQEKESS LKKLLPQAEM FEHLSGKLQQ FMENKSRMLA SGNQPDQDIT
4260 4270 4280 4290 4300
HFFQQIQELN LEMEDQQENL DTLEHLVTEL SSCGFALDLC QHQDRVQNLR
4310 4320 4330 4340 4350
KDFTELQKTV KEREKDASSC QEQLDEFRKL VRTFQKWLKE TEGSIPPTET
4360 4370 4380 4390 4400
SMSAKELEKQ IEHLKSLLDD WASKGTLVEE INCKGTSLEN LIMEITAPDS
4410 4420 4430 4440 4450
QGKTGSILPS VGSSVGSVNG YHTCKDLTEI QCDMSDVNLK YEKLGGVLHE
4460 4470 4480 4490 4500
RQESLQAILN RMEEVHKEAN SVLQWLESKE EVLKSMDAMS SPTKTETVKA
4510 4520 4530 4540 4550
QAESNKAFLA ELEQNSPKIQ KVKEALAGLL VTYPNSQEAE NWKKIQEELN
4560 4570 4580 4590 4600
SRWERATEVT VARQRQLEES ASHLACFQAA ESQLRPWLME KELMMGVLGP
4610 4620 4630 4640 4650
LSIDPNMLNA QKQQVQFMLK EFEARRQQHE QLNEAAQGIL TGPGDVSLST
4660 4670 4680 4690 4700
SQVQKELQSI NQKWVELTDK LNSRSSQIDQ AIVKSTQYQE LLQDLSEKVR
4710 4720 4730 4740 4750
AVGQRLSVQS AISTQPEAVK QQLEETSEIR SDLEQLDHEV KEAQTLCDEL
4760 4770 4780 4790 4800
SVLIGEQYLK DELKKRLETV ALPLQGLEDL AADRINRLQA ALASTQQFQQ
4810 4820 4830 4840 4850
MFDELRTWLD DKQSQQAKNC PISAKLERLQ SQLQENEEFQ KSLNQHSGSY
4860 4870 4880 4890 4900
EVIVAEGESL LLSVPPGEEK RTLQNQLVEL KNHWEELSKK TADRQSRLKD
4910 4920 4930 4940 4950
CMQKAQKYQW HVEDLVPWIE DCKAKMSELR VTLDPVQLES SLLRSKAMLN
4960 4970 4980 4990 5000
EVEKRRSLLE ILNSAADILI NSSEADEDGI RDEKAGINQN MDAVTEELQA
5010 5020 5030 5040 5050
KTGSLEEMTQ RLREFQESFK NIEKKVEGAK HQLEIFDALG SQACSNKNLE
5060 5070 5080 5090 5100
KLRAQQEVLQ ALEPQVDYLR NFTQGLVEDA PDGSDASQLL HQAEVAQQEF
5110 5120 5130 5140 5150
LEVKQRVNSG CVMMENKLEG IGQFHCRVRE MFSQLADLDD ELDGMGAIGR
5160 5170 5180 5190 5200
DTDSLQSQIE DVRLFLNKIH VLKLDIEASE AECRHMLEEE GTLDLLGLKR
5210 5220 5230 5240 5250
ELEALNKQCG KLTERGKARQ EQLELTLGRV EDFYRKLKGL NDATTAAEEA
5260 5270 5280 5290 5300
EALQWVVGTE VEIINQQLAD FKMFQKEQVD PLQMKLQQVN GLGQGLIQSA
5310 5320 5330 5340 5350
GKDCDVQGLE HDMEEINARW NTLNKKVAQR IAQLQEALLH CGKFQDALEP
5360 5370 5380 5390 5400
LLSWLADTEE LIANQKPPSA EYKVVKAQIQ EQKLLQRLLD DRKATVDMLQ
5410 5420 5430 5440 5450
AEGGRIAQSA ELADREKITG QLESLESRWT ELLSKAAARQ KQLEDILVLA
5460 5470 5480 5490 5500
KQFHETAEPI SDFLSVTEKK LANSEPVGTQ TAKIQQQIIR HKALEEDIEN
5510 5520 5530 5540 5550
HATDVHQAVK IGQSLSSLTS PAEQGVLSEK IDSLQARYSE IQDRCCRKAA
5560 5570 5580 5590 5600
LLDQALSNAR LFGEDEVEVL NWLAEVEDKL SSVFVKDFKQ DVLHRQHADH
5610 5620 5630 5640 5650
LALNEEIVNR KKNVDQAIKN GQALLKQTTG EEVLLIQEKL DGIKTRYADI
5660 5670 5680 5690 5700
TVTSSKALRT LEQARQLATK FQSTYEELTG WLREVEEELA TSGGQSPTGE
5710 5720 5730 5740 5750
QIPQFQQRQK ELKKEVMEHR LVLDTVNEVS RALLELVPWR AREGLDKLVS
5760 5770 5780 5790 5800
DANEQYKLVS DTIGQRVDEI DAAIQRSQQY EQAADAELAW VAETKRKLMA
5810 5820 5830 5840 5850
LGPIRLEQDQ TTAQLQVQKA FSIDIIRHKD SMDELFSHRS EIFGTCGEEQ
5860 5870 5880 5890 5900
KTVLQEKTES LIQQYEAISL LNSERYARLE RAQVLVNQFW ETYEELSPWI
5910 5920 5930 5940 5950
EETRALIAQL PSPAIDHEQL RQQQEEMRQL RESIAEHKPH IDKLLKIGPQ
5960 5970 5980 5990 6000
LKELNPEEGE MVEEKYQKAE NMYAQIKEEV RQRALALDEA VSQSTQFHDK
6010 6020 6030 6040 6050
IEPMLETLEN LSSRLRMPPL IPAEVDKIRE CISDNKSATV ELEKLQPSFE
6060 6070 6080 6090 6100
ALKRRGEELI GRSQGADKDL AAKEIQDKLD QMVFFWEDIK ARAEEREIKF
6110 6120 6130 6140 6150
LDVLELAEKF WYDMAALLTT IKDTQDIVHD LESPGIDPSI IKQQVEAAET
6160 6170 6180 6190 6200
IKEETDGLHE ELEFIRILGA DLIFACGETE KPEVRKSIDE MNNAWENLNK
6210 6220 6230 6240 6250
TWKERLEKLE DAMQAAVQYQ DTLQAMFDWL DNTVIKLCTM PPVGTDLNTV
6260 6270 6280 6290 6300
KDQLNEMKEF KVEVYQQQIE MEKLNHQGEL MLKKATDETD RDIIREPLTE
6310 6320 6330 6340 6350
LKHLWENLGE KIAHRQHKLE GALLALGQFQ HALEELMSWL THTEELLDAQ
6360 6370 6380 6390 6400
RPISGDPKVI EVELAKHHVL KNDVLAHQAT VETVNKAGNE LLESSAGDDA
6410 6420 6430 6440 6450
SSLRSRLEAM NQCWESVLQK TEEREQQLQS TLQQAQGFHS EIEDFLLELT
6460 6470 6480 6490 6500
RMESQLSASK PTGGLPETAR EQLDTHMELY SQLKAKEETY NQLLDKGRLM
6510 6520 6530 6540 6550
LLSRDDSGSG SKTEQSVALL EQKWHVVSSK MEERKSKLEE ALNLATEFQN
6560 6570 6580 6590 6600
SLQEFINWLT LAEQSLNIAS PPSLILNTVL SQIEEHKVFA NEVNAHRDQI
6610 6620 6630 6640 6650
IELDQTGNQL KFLSQKQDVV LIKNLLVSVQ SRWEKVVQRS IERGRSLDDA
6660 6670 6680 6690 6700
RKRAKQFHEA WKKLIDWLED AESHLDSELE ISNDPDKIKL QLSKHKEFQK
6710 6720 6730 6740 6750
TLGGKQPVYD TTIRTGRALK EKTLLPEDSQ KLDNFLGEVR DKWDTVCGKS
6760 6770 6780 6790 6800
VERQHKLEEA LLFSGQFMDA LQALVDWLYK VEPQLAEDQP VHGDLDLVMN
6810 6820 6830 6840 6850
LMDAHKVFQK ELGKRTGTVQ VLKRSGRELI ENSRDDTTWV KGQLQELSTR
6860 6870 6880 6890 6900
WDTVCKLSVS KQSRLEQALK QAEVFRDTVH MLLEWLSEAE QTLRFRGALP
6910 6920 6930 6940 6950
DDTEALQSLI DTHKEFMKKV EEKRVDVNSA VAMGEVILAV CHPDCITTIK
6960 6970 6980 6990 7000
HWITIIRARF EEVLTWAKQH QQRLETALSE LVANAELLEE LLAWIQWAET
7010 7020 7030 7040 7050
TLIQRDQEPI PQNIDRVKAL IAEHQTFMEE MTRKQPDVDR VTKTYKRKNI
7060 7070 7080 7090 7100
EPTHAPFIEK SRSGGRKSLS QPTPPPMPIL SQSEAKNPRI NQLSARWQQV
7110 7120 7130 7140 7150
WLLALERQRK LNDALDRLEE LKEFANFDFD VWRKKYMRWM NHKKSRVMDF
7160 7170 7180 7190 7200
FRRIDKDQDG KITRQEFIDG ILASKFPTTK LEMTAVADIF DRDGDGYIDY
7210 7220 7230 7240 7250
YEFVAALHPN KDAYRPTTDA DKIEDEVTRQ VAQCKCAKRF QVEQIGENKY
7260 7270 7280 7290 7300
RFFLGNQFGD SQQLRLVRIL RSTVMVRVGG GWMALDEFLV KNDPCRVHHP
7310 7320 7330 7340 7350
GSKIKRSDSS SSISSQSPIA RGRTNIELRE KFILPEGASQ GMTPFRSRGR
7360 7370 7380 7390 7400
RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS SPATPASGTK TSLQFSRCYD
7410 7420 7430 7440 7450
KPWLVNSKAG TPIRDSHSPD LQLPTPEVIP SSGSKLKRPT PTFHSSRTSL
7460 7470 7480 7490 7500
AGDTSNSSSP ASTGAKTNRA DPKKSASRPG SRAGSRAGSR ASSRRGSDAS
7510 7520 7530 7540 7550
DFDLLETQSA CSDTSESSAA GGQGNSRRGL NKPSKIPTMS KKTTTASPRT

PGPKR
Length:7,555
Mass (Da):856,879
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0607C65FE63FB889
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQK9H3BQK9_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,592Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YES6A0A286YES6_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7I1H0Y7I1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNZ4E9PNZ4_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,028Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000564288; ENSP00000455274; ENSG00000127603

UCSC genome browser

More...
UCSCi
uc057fab.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiH3BPE1, 15 interactors

Proteomic databases

EPDiH3BPE1
jPOSTiH3BPE1
MaxQBiH3BPE1
PeptideAtlasiH3BPE1
PRIDEiH3BPE1
ProteomicsDBi41466

Genome annotation databases

EnsembliENST00000564288; ENSP00000455274; ENSG00000127603
UCSCiuc057fab.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000127603.23
HGNCiHGNC:13664 MACF1
OpenTargetsiENSG00000127603

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000155824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MACF1 human

Gene expression databases

BgeeiENSG00000127603 Expressed in 240 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH3BPE1 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 1 hit
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 3 hits
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 9 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 17 hits
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 20 hits
SM00150 SPEC, 34 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BPE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BPE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: December 11, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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