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Protein

Transporter

Gene

SLC6A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Biological processSymportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:SLC6A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103546.18
HGNCiHGNC:11048 SLC6A2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 83HelicalSequence analysisAdd BLAST19
Transmembranei95 – 116HelicalSequence analysisAdd BLAST22
Transmembranei137 – 164HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103546

PTM / Processingi

Proteomic databases

MaxQBiH3BMY5
PeptideAtlasiH3BMY5
PRIDEiH3BMY5

Expressioni

Gene expression databases

BgeeiENSG00000103546 Expressed in 94 organ(s), highest expression level in chorionic villus
ExpressionAtlasiH3BMY5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BMY5
SMRiH3BMY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

H3BMY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD
60 70 80 90 100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT
Length:200
Mass (Da):22,409
Last modified:April 18, 2012 - v1
Checksum:iD7667727D99D2A6A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P23975SC6A2_HUMAN
Sodium-dependent noradrenaline tran...
SLC6A2 NAT1, NET1, SLC6A5
617Annotation score:
H3BRE9H3BRE9_HUMAN
Transporter
SLC6A2 hCG_2025341
572Annotation score:
H3BML6H3BML6_HUMAN
Transporter
SLC6A2
604Annotation score:
H3BM11H3BM11_HUMAN
Transporter
SLC6A2
561Annotation score:
H3BRS0H3BRS0_HUMAN
Transporter
SLC6A2
295Annotation score:
I3L368I3L368_HUMAN
Sodium-dependent noradrenaline tran...
SLC6A2
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei200Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136621 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000568655; ENSP00000454603; ENSG00000103546
UCSCiuc059uio.1 human

Similar proteinsi

Entry informationi

Entry nameiH3BMY5_HUMAN
AccessioniPrimary (citable) accession number: H3BMY5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 12, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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