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UniProtKB - H3BMQ0 (H3BMQ0_HUMAN)

Entry version 77 (25 May 2022)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Tuberin

Gene

TSC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tuberin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12363, TSC2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000103197

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000103197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		H3BMQ0

PeptideAtlas

More...PeptideAtlasi		H3BMQ0

PRoteomics IDEntifications database

More...PRIDEi		H3BMQ0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		40970

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103197, Expressed in right hemisphere of cerebellum and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		H3BMQ0, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		H3BMQ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1475 – 1702Rap-GAPInterPro annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni666 – 687DisorderedSequence analysisAdd BLAST22
Regioni941 – 965DisorderedSequence analysisAdd BLAST25
Regioni1050 – 1099DisorderedSequence analysisAdd BLAST50
Regioni1116 – 1141DisorderedSequence analysisAdd BLAST26
Regioni1275 – 1296DisorderedSequence analysisAdd BLAST22
Regioni1308 – 1432DisorderedSequence analysisAdd BLAST125
Regioni1709 – 1737DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1050 – 1069Polar residuesSequence analysisAdd BLAST20
Compositional biasi1314 – 1338Polar residuesSequence analysisAdd BLAST25
Compositional biasi1413 – 1428Basic and acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183139

Database of Orthologous Groups

More...OrthoDBi		341431at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap/Ran_GAP_dom
IPR003913, Tuberin
IPR018515, Tuberin-type_domain
IPR027107, Tuberin/Ral-act_asu
IPR024584, Tuberin_N

The PANTHER Classification System

More...PANTHERi		PTHR10063, PTHR10063, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11864, DUF3384, 1 hit
PF02145, Rap_GAP, 1 hit
PF03542, Tuberin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01431, TUBERIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 23 potential isoforms that are computationally mapped.Show allAlign All

H3BMQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGFSGASWS TMAKPTSKDS GLKEKFKILL GLGTPRPNPR SAEGKQTEFI 
        60         70         80         90        100
ITAEILRELS MECGLNNRIR MIGQICEVAK TKKFEEHAVE ALWKAVADLL 
       110        120        130        140        150
QPERPLEARH AVLALLKAIV QGQGERLGVL RALFFKVIKD YPSNEDLHER 
       160        170        180        190        200
LEVFKALTDN GRHITYLEEE LADFVLQWMD VGLSSEFLLV LVNLVKFNSC 
       210        220        230        240        250
YLDEYIARMV QMICLLCVRT ASSVDIEVSL QVLDAVVCYN CLPAESLPLF 
       260        270        280        290        300
IVTLCRTINV KELCEPCWKL MRNLLGTHLG HSAIYNMCHL MEDRAYMEDA 
       310        320        330        340        350
PLLRGAVFFV GMALWGAHRL YSLRNSPTSV LPSFYQAMAC PNEVVSYEIV 
       360        370        380        390        400
LSITRLIKKY RKELQVVAWD ILLNIIERLL QQLQTLDSPE LRTIVHDLLT 
       410        420        430        440        450
TVEELCDQNE FHGSQERYFE LVERCADQRP ESSLLNLISY RAQSIHPAKD 
       460        470        480        490        500
GWIQNLQALM ERFFRSESRG AVRIKVLDVL SFVLLINRQF YEEELINSVV 
       510        520        530        540        550
ISQLSHIPED KDHQVRKLAT QLLVDLAEGC HTHHFNSLLD IIEKVMARSL 
       560        570        580        590        600
SPPPELEERD VAAYSASLED VKTAVLGLLV ILQTKLYTLP ASHATRVYEM 
       610        620        630        640        650
LVSHIQLHYK HSYTLPIASS IRLQAFDFLL LLRADSLHRL GLPNKDGVVR 
       660        670        680        690        700
FSPYCVCDYM EPERGSEKKT SGPLSPPTGP PGPAPAGPAV RLGSVPYSLL 
       710        720        730        740        750
FRVLLQCLKQ ESDWKVLKLV LGRLPESLRY KVLIFTSPCS VDQLCSALCS 
       760        770        780        790        800
MLSGPKTLER LRGAPEGFSR TDLHLAVVPV LTALISYHNY LDKTKQREMV 
       810        820        830        840        850
YCLEQGLIHR CASQCVVALS ICSVEMPDII IKALPVLVVK LTHISATASM 
       860        870        880        890        900
AVPLLEFLST LARLPHLYRN FAAEQYASVF AISLPYTNPS KFNQYIVCLA 
       910        920        930        940        950
HHVIAMWFIR CRLPFRKDFV PFITKGLRSN VLLSFDDTPE KDSFRARSTS 
       960        970        980        990       1000
LNERPKRIQT SLTSASLGSA DENSVAQADD SLKNLHLELT ETCLDMMARY 
      1010       1020       1030       1040       1050
VFSNFTAVPK RSPVGEFLLA GGRTKTWLVG NKLVTVTTSV GTGTRSLLGL 
      1060       1070       1080       1090       1100
DSGELQSGPE SSSSPGVHVR QTKEAPAKLE SQAGQQVSRG ARDRVRSMSG 
      1110       1120       1130       1140       1150
GHGLRVGALD VPASQFLGSA TSPGPRTAPA AKPEKASAGT RVPVQEKTNL 
      1160       1170       1180       1190       1200
AAYVPLLTQG WAEILVRRPT GNTSWLMSLE NPLSPFSSDI NNMPLQELSN 
      1210       1220       1230       1240       1250
ALMAAERFKE HRDTALYKSL SVPAASTAKP PPLPRSNTDS AVVMEEGSPG 
      1260       1270       1280       1290       1300
EVPVLVEPPG LEDVEAALGM DRRTDAYSRS SSVSSQEEKS LHAEELVGRG 
      1310       1320       1330       1340       1350
IPIERVVSSE GGRPSVDLSF QPSQPLSKSS SSPELQTLQD ILGDPGDKAD 
      1360       1370       1380       1390       1400
VGRLSPEVKA RSQSGTLDGE SAAWSASGED SRGQPEGPLP SSSPRSPSGL 
      1410       1420       1430       1440       1450
RPRGYTISDS APSRRGKRVE RDALKSRATA SNAEKVPGIN PSFVFLQLYH 
      1460       1470       1480       1490       1500
SPFFGDESNK PILLPNESQS FERSVQLLDQ IPSYDTHKIA VLYVGEGQSN 
      1510       1520       1530       1540       1550
SELAILSNEH GSYRYTEFLT GLGRLIELKD CQPDKVYLGG LDVCGEDGQF 
      1560       1570       1580       1590       1600
TYCWHDDIMQ AVFHIATLMP TKDVDKHRCD KKRHLGNDFV SIVYNDSGED 
      1610       1620       1630       1640       1650
FKLGTIKGQF NFVHVIVTPL DYECNLVSLQ CRKDMEGLVD TSVAKIVSDR 
      1660       1670       1680       1690       1700
NLPFVARQMA LHANMASQVH HSRSNPTDIY PSKWIARLRH IKRLRQRICE 
      1710       1720       1730       1740       1750
EAAYSNPSLP LVHPPSHSKA PAQTPAEPTP GYEVGQRKRL ISSVEDFTEF 

V
Length:1,751
Mass (Da):194,390
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6DCA7B0DC5E3B59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P49815TSC2_HUMAN
Tuberin
TSC2 TSC4
1,807Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X5D2U8X5D2U8_HUMAN
Tuberin
TSC2
1,741Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5F1A0A2R8Y5F1_HUMAN
Tuberin
TSC2
1,738Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7C8A0A2R8Y7C8_HUMAN
Tuberin
TSC2
1,782Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7X5A0A2R8Y7X5_HUMAN
Tuberin
TSC2
1,769Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDZ2A0A2R8YDZ2_HUMAN
Tuberin
TSC2
1,760Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGD6A0A2R8YGD6_HUMAN
Tuberin
TSC2
1,805Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGU4A0A2R8YGU4_HUMAN
Tuberin
TSC2
1,739Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6C9A0A2R8Y6C9_HUMAN
Tuberin
TSC2
1,359Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDR3A0A2R8YDR3_HUMAN
Tuberin
TSC2
1,781Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC093513 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001305761.1, NM_001318832.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000568454.6; ENSP00000454487.1; ENSG00000103197.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7249

UCSC genome browser

More...UCSCi		uc059pfs.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093513 Genomic DNA No translation available.
RefSeqiNP_001305761.1, NM_001318832.1

3D structure databases

SMRiH3BMQ0
ModBaseiSearch...

Proteomic databases

MaxQBiH3BMQ0
PeptideAtlasiH3BMQ0
PRIDEiH3BMQ0
ProteomicsDBi40970

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3702, 2059 antibodies from 45 providers

The DNASU plasmid repository

More...DNASUi		7249

Genome annotation databases

EnsembliENST00000568454.6; ENSP00000454487.1; ENSG00000103197.18
GeneIDi7249
UCSCiuc059pfs.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7249
HGNCiHGNC:12363, TSC2
OpenTargetsiENSG00000103197
VEuPathDBiHostDB:ENSG00000103197

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00950000183139
OrthoDBi341431at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7249, 142 hits in 1104 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7249

Gene expression databases

BgeeiENSG00000103197, Expressed in right hemisphere of cerebellum and 223 other tissues
ExpressionAtlasiH3BMQ0, baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap/Ran_GAP_dom
IPR003913, Tuberin
IPR018515, Tuberin-type_domain
IPR027107, Tuberin/Ral-act_asu
IPR024584, Tuberin_N
PANTHERiPTHR10063, PTHR10063, 3 hits
PfamiView protein in Pfam
PF11864, DUF3384, 1 hit
PF02145, Rap_GAP, 1 hit
PF03542, Tuberin, 1 hit
PRINTSiPR01431, TUBERIN
SUPFAMiSSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50085, RAPGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BMQ0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BMQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 25, 2022
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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