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Protein
Submitted name:

Guanine nucleotide exchange factor DBS

Gene

MCF2L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide exchange factor DBSImported
Gene namesi
Name:MCF2LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000126217.20
HGNCiHGNC:14576 MCF2L

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126217

PTM / Processingi

Proteomic databases

MaxQBiH3BLT1
PeptideAtlasiH3BLT1
PRIDEiH3BLT1

Expressioni

Gene expression databases

BgeeiENSG00000126217 Expressed in 195 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiH3BLT1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH3BLT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 86PHInterPro annotationAdd BLAST86
Domaini196 – 257SH3InterPro annotationAdd BLAST62

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPNH Eukaryota
ENOG410XNYV LUCA
GeneTreeiENSGT00930000150837

Family and domain databases

CDDicd11857 SH3_DBS, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035532 DBS_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

H3BLT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XHLFLHEKAV LFCKKREENG EGYEKAPSYS YKQSLNMAAV GITENVKGDA
60 70 80 90 100
KKFEIWYNAR EEVYIVQAPT PEIKAAWVNE IRKVLTSQLQ ACREASQHRA
110 120 130 140 150
LEQSQSLPLP APTSTSPSRG NSRNIKKLEE RKTDPLSLEG YVSSAPLTKP
160 170 180 190 200
PEKGKGWSKT SHSLEAPEDD GGWSSAEEQI NSSDAEEDGG LGPKKLVPGK
210 220 230 240 250
YTVVADHEKG GPDALRVRSG DVVELVQEGD EGLWYVRDPT TGKEGWVPAS
260 270 280 290
SLSVRLGPSG SAQCLSSSES SPGSAVLSNS SSCSEGGQAP FSDLQG
Length:296
Mass (Da):31,901
Last modified:April 18, 2012 - v1
Checksum:i906FE2B40B7BD57D
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15068MCF2L_HUMAN
Guanine nucleotide exchange factor ...
MCF2L KIAA0362, OST
1,137Annotation score:
H7BYP9H7BYP9_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
793Annotation score:
A2A3G7A2A3G7_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
136Annotation score:
H0Y4M6H0Y4M6_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
336Annotation score:
A2A640A2A640_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
213Annotation score:
H7C2S1H7C2S1_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
317Annotation score:
H7C275H7C275_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
189Annotation score:
B7ZBR9B7ZBR9_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
136Annotation score:
H0Y7A3H0Y7A3_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
151Annotation score:
A2A639A2A639_HUMAN
Guanine nucleotide exchange factor ...
MCF2L
86Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA No translation available.
AL162454 Genomic DNA No translation available.
AL356740 Genomic DNA No translation available.
AL596093 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000261963; ENSP00000261963; ENSG00000126217
UCSCiuc058yky.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA No translation available.
AL162454 Genomic DNA No translation available.
AL356740 Genomic DNA No translation available.
AL596093 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH3BLT1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH3BLT1
PeptideAtlasiH3BLT1
PRIDEiH3BLT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261963; ENSP00000261963; ENSG00000126217
UCSCiuc058yky.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000126217.20
HGNCiHGNC:14576 MCF2L
OpenTargetsiENSG00000126217
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPNH Eukaryota
ENOG410XNYV LUCA
GeneTreeiENSGT00930000150837

Miscellaneous databases

ChiTaRSiMCF2L human

Gene expression databases

BgeeiENSG00000126217 Expressed in 195 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiH3BLT1 baseline and differential

Family and domain databases

CDDicd11857 SH3_DBS, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035532 DBS_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BLT1_HUMAN
AccessioniPrimary (citable) accession number: H3BLT1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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