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Entry version 56 (07 Oct 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Zinc finger homeobox protein 4

Gene

Zfhx4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2125 – 2184HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2222 – 2281HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2598 – 2657HomeoboxPROSITE-ProRule annotationAdd BLAST60
DNA bindingi2921 – 2980HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger homeobox protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfhx4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2137668, Zfhx4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H3BLK8

PRoteomics IDEntifications database

More...
PRIDEi
H3BLK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025255, Expressed in stria vascularis of cochlear duct and 254 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H3BLK8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1393 – 1416C2H2-typeInterPro annotationAdd BLAST24
Domaini1537 – 1568C2H2-typeInterPro annotationAdd BLAST32
Domaini1589 – 1618C2H2-typeInterPro annotationAdd BLAST30
Domaini1941 – 1969C2H2-typeInterPro annotationAdd BLAST29
Domaini2123 – 2183HomeoboxInterPro annotationAdd BLAST61
Domaini2220 – 2280HomeoboxInterPro annotationAdd BLAST61
Domaini2308 – 2337C2H2-typeInterPro annotationAdd BLAST30
Domaini2596 – 2656HomeoboxInterPro annotationAdd BLAST61
Domaini2668 – 2696C2H2-typeInterPro annotationAdd BLAST29
Domaini2919 – 2979HomeoboxInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni426 – 479DisorderedSequence analysisAdd BLAST54
Regioni521 – 611DisorderedSequence analysisAdd BLAST91
Regioni1126 – 1165DisorderedSequence analysisAdd BLAST40
Regioni1295 – 1362DisorderedSequence analysisAdd BLAST68
Regioni1490 – 1517DisorderedSequence analysisAdd BLAST28
Regioni1804 – 1898DisorderedSequence analysisAdd BLAST95
Regioni1988 – 2063DisorderedSequence analysisAdd BLAST76
Regioni2374 – 2468DisorderedSequence analysisAdd BLAST95
Regioni2546 – 2601DisorderedSequence analysisAdd BLAST56
Regioni2802 – 2847DisorderedSequence analysisAdd BLAST46
Regioni2866 – 2922DisorderedSequence analysisAdd BLAST57
Regioni3107 – 3212DisorderedSequence analysisAdd BLAST106
Regioni3317 – 3374DisorderedSequence analysisAdd BLAST58
Regioni3480 – 3501DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2274 – 2298Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 25PolarSequence analysisAdd BLAST25
Compositional biasi34 – 54PolyampholyteSequence analysisAdd BLAST21
Compositional biasi432 – 448PolyampholyteSequence analysisAdd BLAST17
Compositional biasi542 – 556PolarSequence analysisAdd BLAST15
Compositional biasi1325 – 1356PolyampholyteSequence analysisAdd BLAST32
Compositional biasi1821 – 1842PolarSequence analysisAdd BLAST22
Compositional biasi1847 – 1885PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1992 – 2018Pro-richSequence analysisAdd BLAST27
Compositional biasi2028 – 2062Pro-richSequence analysisAdd BLAST35
Compositional biasi2409 – 2437PolarSequence analysisAdd BLAST29
Compositional biasi2438 – 2452Pro-richSequence analysisAdd BLAST15
Compositional biasi2453 – 2468PolarSequence analysisAdd BLAST16
Compositional biasi2546 – 2565PolarSequence analysisAdd BLAST20
Compositional biasi2571 – 2601PolyampholyteSequence analysisAdd BLAST31
Compositional biasi2867 – 2892PolyampholyteSequence analysisAdd BLAST26
Compositional biasi2893 – 2914PolarSequence analysisAdd BLAST22
Compositional biasi3109 – 3149PolarSequence analysisAdd BLAST41
Compositional biasi3150 – 3168Pro-richSequence analysisAdd BLAST19
Compositional biasi3175 – 3212PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3317 – 3335PolarSequence analysisAdd BLAST19
Compositional biasi3352 – 3374PolyampholyteSequence analysisAdd BLAST23
Compositional biasi3485 – 3501PolarSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159542

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMINQGG

TreeFam database of animal gene trees

More...
TreeFami
TF323288

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H3BLK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METCDSPPIS RQENGQSTSK LCGMTQLDNE VPEKVAGIEP DRENSSSHDN
60 70 80 90 100
LKTDERKSEV LLGFSIENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC
110 120 130 140 150
PNARLPVLKD DESETSELED SDVENLTGEI VYQPDGSAYI IEDSKESGQN
160 170 180 190 200
AQTGANSKLF STAMFLDSLA SAGEKSDQSS TAPVSFYPQI INTFHIASSL
210 220 230 240 250
GKPFTADPAF PNTSALAGVG PVLHSFRVYD LRHKREKDYL TSDGSAKNSC
260 270 280 290 300
VSKDVPNNVD LSKFDGCVSD GKRKPVLMCF LCKLSFGYIR SFVTHAVHDH
310 320 330 340 350
RMTLNDEEQR LLSNKCVSAI IQGIGKDKEP LISFLEPKKS TSVYPNFSTT
360 370 380 390 400
NLIGPDPTFR GLWSAFHVEN GDSLQAGFAF LKGSASPSSS AEQPLGITHM
410 420 430 440 450
PKAEVNLGGL SSLVVNTPIT SVSLSHLSSE SSKMSESKDQ ENNCERPKES
460 470 480 490 500
TILHPNVGCP VKSEPTEPGD EDEEDAYSNE LDDEEVLGEL TDSIGNKDFP
510 520 530 540 550
LLNQSISPLS SSVLKFIEKG TSSSSGTIAE DTEKKKQAAA AGRSNGNVTN
560 570 580 590 600
SYSIGGKDFA DGSISRDGTT AAPSETTHGD EDSSTTHQHG FTPSTPGTPG
610 620 630 640 650
PGGDGSPGNG IECPKCDTVL GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH
660 670 680 690 700
YKYQQTLEAH MKEKHPEPGG SCVYCKTGQP HPRLARGESY TCGYKPFRCE
710 720 730 740 750
VCNYSTTTKG NLSIHMQSDK HLNNVQNLQN GNGEQVFGHS APTPNTSLSG
760 770 780 790 800
CGTPSPSKPK QKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM
810 820 830 840 850
KQIQHNLHLG LAPAEAELYQ YYLAQNIGLT GMKLENPAET QLLLNPFQFD
860 870 880 890 900
SATAAALAPG LVNNELPPEI RLASGQLMGD DLSLLTAGEL SPYISDPALK
910 920 930 940 950
LFQCAVCNKF TSDSLEALSV HVNSERSLPE EEWRAVIGDI YQCKLCNYNT
960 970 980 990 1000
QLKANFQLHC KTDKHMQKYQ LVAHIKEGGK SNEWRLKCIA IGNPVHLKCN
1010 1020 1030 1040 1050
ACDYYTNSVD KLRLHTTNHR HEAALKLYKH LQKQEGAVNS ESCYYYCAVC
1060 1070 1080 1090 1100
DYSSKIKLNL VQHVRSVKHQ QTEGLRKLQL HQQGLPSEED NLSEIFFVKE
1110 1120 1130 1140 1150
CPANELETAS LGARNGEDEL IEQQLKAASE EPSEDAGDPL KPPTVAEDDE
1160 1170 1180 1190 1200
KEAHKRDNSE GKISTKDPVI VPEKELKVVT GATQPLLLAK EDNTGTKRSK
1210 1220 1230 1240 1250
PTEDNKFCPE QFYQCPYCNY NSRDQSRIQM HVLSQHSVQP VICCPLCQDV
1260 1270 1280 1290 1300
LSNKMHLQLH LTHLHSVSPD CVEKLLMTVP VPDVMMPNSM LLPAAAPEKS
1310 1320 1330 1340 1350
EQDPPTALTA EGSGKYSGDS PVDDKSMSGL EDSKVGVEIK NEEQKPAKEP
1360 1370 1380 1390 1400
VEASEWNKTS SKDVNISDAL QDQLNEQQKR QPLSVSDRHV YKYRCNHCSL
1410 1420 1430 1440 1450
AFKTMQKLQI HSQYHAIRAA TMCTLCQRSF RTFQALKKHL EAGHPELSEA
1460 1470 1480 1490 1500
ELQQLYASLP MNGELWAESE TMTQDDHGID QEMEREYEVD HEGKASPVES
1510 1520 1530 1540 1550
DSSSIPDDLG LEPKRTLPFR KGPNFTMEKF LDPSRPYKCT VCKESFTQKN
1560 1570 1580 1590 1600
ILLVHYNSVS HLHKLKKVLQ EASSPVPQEA NSSTDNKPYK CSTCSVAYSQ
1610 1620 1630 1640 1650
SSTLEIHMRS VLHQTKARAA KLEPSRHLPS GHSITAAVNS PGQGMLESMS
1660 1670 1680 1690 1700
LASVNSKDTH LDAKELNKKQ TPELISAQPT HHPPPRSPAQ IQMQLQHELQ
1710 1720 1730 1740 1750
QQAAFFQPQF LNPAFLPHFP MTPEALLQFQ QPQFLFPFYI PGAEFSLGPD
1760 1770 1780 1790 1800
LGLPTSTTFG VPGMTGMAGS LLEDLKQQIQ TQHHVGQTQL QFLQQAQQYQ
1810 1820 1830 1840 1850
AVQPQLQPQN QQPPLPQQQQ PQQQPSKLLK QEQGSLASTD CQLMKDMPSY
1860 1870 1880 1890 1900
KEAEEVTEKQ EKPKQEFIND TEGLKDSKDI KKQKSLEPCI PPPRIASGAR
1910 1920 1930 1940 1950
GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENSDK LECGICGKLF
1960 1970 1980 1990 2000
SNVLILKSHQ EHVHGQFFPY GALEKFARQY REAYDKLYPI SPSSPETPPP
2010 2020 2030 2040 2050
PPPPPPLPPA PPQPSTLGPV KIPNTVSAPL QAPPPTPPPP PPPPPPPPPP
2060 2070 2080 2090 2100
PPPPPPPSAP QQVQLPVSLD LPLFPSIMMQ PVQHPALPPQ LALQLPQMDT
2110 2120 2130 2140 2150
LSADLTQLCQ QQLGIDPNFL RHSQFKRPRT RITDDQLKIL RAYFDINNSP
2160 2170 2180 2190 2200
SEEQIQEMAE KSGLSQKVIK HWFRNTLFKE RQRNKDSPYN FSNPPITVLE
2210 2220 2230 2240 2250
DIRIDPQPTS LEHYKSDAAF SKRSSRTRFT DYQLRVLQDF FDTNAYPKDD
2260 2270 2280 2290 2300
EIEQLSTVLN LPTRVIVVWF QNARQKARKS YENQAEAKDN EKRELTNERY
2310 2320 2330 2340 2350
IRTSNMQYQC KKCNVVFPRI FDLITHQKKQ CYKDEDDDAQ DESQTEDSMD
2360 2370 2380 2390 2400
ATDQVLYKHC MVSGQTDTAK STATLVASSG SGTSTPLIPS PKPEPEKNSP
2410 2420 2430 2440 2450
KTEYPGEKTK QSDPSLPQGT KSAPSSVLTS SEPQQASIPQ PPTQPPKQPQ
2460 2470 2480 2490 2500
LIGRPPSASQ TPIPSSPLQI SMTSLQNSLP PQLLQYPCDQ CTIAFPTLEL
2510 2520 2530 2540 2550
WKEHQHMHFL AAQNQFLHSP FLERPMDMPY MIFDPNNPLM TGQLLGSSLT
2560 2570 2580 2590 2600
QMPPQTSTAH TTAPASVAAS LKRKLEDKED NNCSEKEGGN SGEDQHRDKR
2610 2620 2630 2640 2650
LRTTITPEQL EILYEKYLLD SNPTRKMLDH IAREVGLKKR VVQVWFQNTR
2660 2670 2680 2690 2700
ARERKGQFRA VGPAQSHKRC PFCRALFKAK SALESHIRSR HWNEGKQAGY
2710 2720 2730 2740 2750
SLPPSPLIST EDGGESPQKY IYFDYPSLPL TKIDLSTENE LASTVSTPVS
2760 2770 2780 2790 2800
KTAELSPKNL LSPSSFKAEC PEDVENLNAP SADAGYDQSK TDFDETSSIN
2810 2820 2830 2840 2850
TAISDATTGD EGAADMENTG GSGEVKPALS PKETKTLDSL QKPATTPTTE
2860 2870 2880 2890 2900
VCDDKFLFSL TSPSIHFNDK DGDHDQSFYI TDDPDDNADR SETSSIADPS
2910 2920 2930 2940 2950
SPNPFGSSNP FKSKSNDRPG HKRFRTQMSN LQLKVLKACF SDYRTPTMQE
2960 2970 2980 2990 3000
CEMLGNEIGL PKRVVQVWFQ NARAKEKKFK INIGKPFMIN QSGTDGTKPE
3010 3020 3030 3040 3050
CTLCGVKYSA RLSIRDHIFS KQHISKVRET VGSQLDREKD YLAPTTVRQL
3060 3070 3080 3090 3100
MAQQELDRIK KASDVLGLTV QQQGITDNCS LHGISLQAAY PGLPGLPPVI
3110 3120 3130 3140 3150
LPGMNGPSSL PGFPQNSNTL TSPGTGMLGF PSSATSSPAL SLSSGPTKSL
3160 3170 3180 3190 3200
LQTPPPPPPP PPPPSSLSGQ QTEPQNKESE KKQTKPNKVK KIKEEESEAI
3210 3220 3230 3240 3250
KPEKHPKKEE KISSALTVLG KVVGETHMDP TQLQALQNAI AGDPASFIGG
3260 3270 3280 3290 3300
QFLPYFIPGF ASYFSPQLPG TVQGGYLPPI CGMESLFPYG PAVPQTLAGL
3310 3320 3330 3340 3350
SPGALLQQYQ QYQQSLQDSL QKQQKQQQEQ QQKPVPAKTA KGEGDQPQSS
3360 3370 3380 3390 3400
NEASETKEEK STAPESTKEE VQLDSKSAEF SDTCIVPFVK YEFVCRKCQM
3410 3420 3430 3440 3450
MFTDEDATVN HQKSFCYFGQ PLIDPQETVL RIPVSKYQCL ACDLALSGNE
3460 3470 3480 3490 3500
ALSQHLQSSL HKEKTIKQAM RNAKEHVRLL PHSVCSPPPN TSSTSPSAAS
3510 3520 3530 3540 3550
SNNTYPHLSC FSMKSWPNIL FQASARKAAS SPSSPPSLSL PSTVTSSLCS
3560 3570 3580 3590 3600
TSGVQTSLPT ESCSDESDSE LSQKLQDLDN SLEVKAKPAS GLDGNFNSVR

MDMFSV
Length:3,606
Mass (Da):398,056
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57EA6B95DD491D78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JJN2ZFHX4_MOUSE
Zinc finger homeobox protein 4
Zfhx4 Zfh4
3,550Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5A7E9Q5A7_MOUSE
Zinc finger homeobox protein 4
Zfhx4
3,581Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXP5V9GXP5_MOUSE
Zinc finger homeobox protein 4
Zfhx4
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC115031 Genomic DNA No translation available.
AC118246 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000175866; ENSMUSP00000135827; ENSMUSG00000025255

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115031 Genomic DNA No translation available.
AC118246 Genomic DNA No translation available.

3D structure databases

SMRiH3BLK8
ModBaseiSearch...

Proteomic databases

MaxQBiH3BLK8
PRIDEiH3BLK8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1757, 60 antibodies

Genome annotation databases

EnsembliENSMUST00000175866; ENSMUSP00000135827; ENSMUSG00000025255

Organism-specific databases

MGIiMGI:2137668, Zfhx4

Phylogenomic databases

GeneTreeiENSGT00940000159542
OMAiFMINQGG
TreeFamiTF323288

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Zfhx4, mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025255, Expressed in stria vascularis of cochlear duct and 254 other tissues

Family and domain databases

CDDicd00086, homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3BLK8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3BLK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 7, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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