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Protein
Submitted name:

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Gene

Gnb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Imported
Gene namesi
Name:Gnb1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95781 Gnb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiH3BKR2
PRIDEiH3BKR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029064 Expressed in 297 organ(s), highest expression level in retina
ExpressionAtlasiH3BKR2 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiH3BKR2, 1 interactor

Structurei

3D structure databases

SMRiH3BKR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 263WD_REPEATS_REGIONInterPro annotationAdd BLAST213
Repeati51 – 92WDPROSITE-ProRule annotationAdd BLAST42
Repeati139 – 179WDPROSITE-ProRule annotationAdd BLAST41
Repeati180 – 221WDPROSITE-ProRule annotationAdd BLAST42
Repeati222 – 263WDPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 31Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H3BKR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR
160 170 180 190 200
FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV
210 220 230 240 250
SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC
260 270
RLFDLRADQE LMTYSHDNII CGI
Length:273
Mass (Da):30,199
Last modified:October 5, 2016 - v8
Checksum:i0D3CB339D86FF497
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P62874GBB1_MOUSE
Guanine nucleotide-binding protein ...
Gnb1
340Annotation score:
H3BLF7H3BLF7_MOUSE
Guanine nucleotide-binding protein ...
Gnb1
108Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei273Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627405 Genomic DNA No translation available.
AL670227 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000177094; ENSMUSP00000135492; ENSMUSG00000029064

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627405 Genomic DNA No translation available.
AL670227 Genomic DNA No translation available.

3D structure databases

SMRiH3BKR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiH3BKR2, 1 interactor

Proteomic databases

PeptideAtlasiH3BKR2
PRIDEiH3BKR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000177094; ENSMUSP00000135492; ENSMUSG00000029064

Organism-specific databases

MGIiMGI:95781 Gnb1

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239

Miscellaneous databases

ChiTaRSiGnb1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029064 Expressed in 297 organ(s), highest expression level in retina
ExpressionAtlasiH3BKR2 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3BKR2_MOUSE
AccessioniPrimary (citable) accession number: H3BKR2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 48 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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