UniProtKB - H3BJQ7 (H3BJQ7_MOUSE)
Protein
Peroxiredoxin-5
Gene
Prdx5
Organism
Mus musculus (Mouse)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.UniRule annotation
Catalytic activityi
- [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2OUniRule annotationARBA annotationEC:1.11.1.24UniRule annotationARBA annotation
GO - Molecular functioni
- peroxidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | AntioxidantUniRule annotationARBA annotation, Oxidoreductase, PeroxidaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Prdx5Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859821, Prdx5 |
Subcellular locationi
Peroxisome
- Peroxisome matrix ARBA annotation
Peroxisome
- peroxisomal matrix Source: UniProtKB-SubCell
PTM / Processingi
Proteomic databases
jPOSTi | H3BJQ7 |
MaxQBi | H3BJQ7 |
PeptideAtlasi | H3BJQ7 |
PRIDEi | H3BJQ7 |
PTM databases
SwissPalmi | H3BJQ7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024953, Expressed in granulocyte and 322 other tissues |
ExpressionAtlasi | H3BJQ7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 213 | ThioredoxinInterPro annotationAdd BLAST | 159 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00390000018173 |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H3BJQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWGRQDIQES EDRNGPLNRQ ALFLLGVSTG SIKVYLCGCG SLVSLHSVLP
60 70 80 90 100
WSLFLQVGDA IPSVEVFEGE PGKKVNLAEL FKGKKGVLFG VPGAFTPGCS
110 120 130 140 150
KTHLPGFVEQ AGALKAKGAQ VVACLSVNDV FVIEEWGRAH QAEGKVRLLA
160 170 180 190 200
DPTGAFGKAT DLLLDDSLVS LFGNRRLKRF SMVIDNGIVK ALNVEPDGTG
210
LTCSLAPNIL SQL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP99029 | PRDX5_MOUSE | Peroxiredoxin-5, mitochondrial | Prdx5 Prdx6 | 210 | Annotation score: | ||
A0A494BAZ4 | A0A494BAZ4_MOUSE | Peroxiredoxin-5 | Prdx5 | 142 | Annotation score: | ||
G3UZJ4 | G3UZJ4_MOUSE | Thioredoxin-dependent peroxiredoxin | Prdx5 | 166 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120557 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000149261; ENSMUSP00000135084; ENSMUSG00000024953 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120557 Genomic DNA No translation available. |
3D structure databases
SMRi | H3BJQ7 |
ModBasei | Search... |
PTM databases
SwissPalmi | H3BJQ7 |
Proteomic databases
jPOSTi | H3BJQ7 |
MaxQBi | H3BJQ7 |
PeptideAtlasi | H3BJQ7 |
PRIDEi | H3BJQ7 |
Protocols and materials databases
Antibodypediai | 3276, 423 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000149261; ENSMUSP00000135084; ENSMUSG00000024953 |
Organism-specific databases
MGIi | MGI:1859821, Prdx5 |
Phylogenomic databases
GeneTreei | ENSGT00390000018173 |
Miscellaneous databases
ChiTaRSi | Prdx5, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024953, Expressed in granulocyte and 322 other tissues |
ExpressionAtlasi | H3BJQ7, baseline and differential |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BJQ7_MOUSE | |
Accessioni | H3BJQ7Primary (citable) accession number: H3BJQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |