UniProtKB - H3BJM0 (H3BJM0_MOUSE)
Protein
Submitted name:
Zinc finger protein Gfi-1
Gene
Gfi1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cellular response to lipopolysaccharide Source: Ensembl
- hemopoiesis Source: InterPro
- negative regulation of calcidiol 1-monooxygenase activity Source: Ensembl
- negative regulation of neuron projection development Source: Ensembl
- positive regulation of interleukin-6-mediated signaling pathway Source: Ensembl
- regulation of histone H3-K4 methylation Source: InterPro
- regulation of toll-like receptor signaling pathway Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger protein Gfi-1Imported |
Gene namesi | Name:Gfi1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103170, Gfi1 |
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- nuclear matrix Source: Ensembl
Other locations
- transcription repressor complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029275, Expressed in utricle of membranous labyrinth and 131 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 322 – 350 | C2H2-typeInterPro annotationAdd BLAST | 29 | |
Domaini | 351 – 378 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 379 – 406 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 407 – 434 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 435 – 462 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 463 – 489 | C2H2-typeInterPro annotationAdd BLAST | 27 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 55 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 71 – 142 | DisorderedSequence analysisAdd BLAST | 72 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156166 |
OrthoDBi | 1318335at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR029840, GFI1/1B IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24404:SF46, PTHR24404:SF46, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H3BJM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWRQRASGGL LLSALPSAPE FPASDDQGKP GGPLCQERAA PPPGRQLQHE
60 70 80 90 100
NSEYPRVQTF VQRLTTMPRS FLVKSKKAHS YHQPRSPGPD YSLRLETVPA
110 120 130 140 150
PGRAEGGAVS AGESKMEPRE RLSPDSQLTE APDRASASPN SCEGSVCDPC
160 170 180 190 200
SEFEDFWRPP SPSVSPASEK SLCRSLDEAQ PYTLPFKPYA WSGLAGSDLR
210 220 230 240 250
HLVQSYRQCS ALERSAGLSL FCERGSEPGR PAARYGPEQA AGGAGAGQPG
260 270 280 290 300
SCGVAGGATS AAGLGLYGDF APAAAGLYER PSTAAGRLYQ DHGHELHADK
310 320 330 340 350
SVGVKVESEL LCTRLLLGGG SYKCIKCSKV FSTPHGLEVH VRRSHSGTRP
360 370 380 390 400
FACEMCGKTF GHAVSLEQHK AVHSQERSFD CKICGKSFKR SSTLSTHLLI
410 420 430 440 450
HSDTRPYPCQ YCGKRFHQKS DMKKHTFIHT GEKPHKCQVC GKAFSQSSNL
460 470 480
ITHSRKHTGF KPFGCDLCGK GFQRKVDLRR HRETQHGLK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP70338 | GFI1_MOUSE | Zinc finger protein Gfi-1 | Gfi1 Gfi-1 | 423 | Annotation score: | ||
H3BLQ9 | H3BLQ9_MOUSE | Zinc finger protein Gfi-1 | Gfi1 | 186 | Annotation score: | ||
A0A0R4J292 | A0A0R4J292_MOUSE | Zinc finger protein Gfi-1 | Gfi1 | 423 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138666 Genomic DNA No translation available. |
RefSeqi | NP_001254550.1, NM_001267621.1 |
Genome annotation databases
Ensembli | ENSMUST00000065478; ENSMUSP00000135039; ENSMUSG00000029275 |
GeneIDi | 14581 |
UCSCi | uc029vkg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138666 Genomic DNA No translation available. |
RefSeqi | NP_001254550.1, NM_001267621.1 |
3D structure databases
SMRi | H3BJM0 |
ModBasei | Search... |
Proteomic databases
jPOSTi | H3BJM0 |
Protocols and materials databases
Antibodypediai | 4402, 275 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000065478; ENSMUSP00000135039; ENSMUSG00000029275 |
GeneIDi | 14581 |
UCSCi | uc029vkg.1, mouse |
Organism-specific databases
CTDi | 2672 |
MGIi | MGI:103170, Gfi1 |
Phylogenomic databases
GeneTreei | ENSGT00940000156166 |
OrthoDBi | 1318335at2759 |
Miscellaneous databases
BioGRID-ORCSi | 14581, 2 hits in 18 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029275, Expressed in utricle of membranous labyrinth and 131 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029840, GFI1/1B IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR24404:SF46, PTHR24404:SF46, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3BJM0_MOUSE | |
Accessioni | H3BJM0Primary (citable) accession number: H3BJM0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |