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Protein
Submitted name:

Cholinergic receptor nicotinic gamma subunit

Gene

CHRNG

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor nicotinic gamma subunitImported
Gene namesi
Name:CHRNGImported
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)Imported
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi
  • UP000008672 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 259HelicalSequence analysisAdd BLAST23
Transmembranei271 – 287HelicalSequence analysisAdd BLAST17
Transmembranei299 – 324HelicalSequence analysisAdd BLAST26
Transmembranei469 – 491HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500358099318 – 508Sequence analysisAdd BLAST491

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7897.ENSLACP00000017900

Structurei

3D structure databases

ProteinModelPortaliH3B7M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 236Neur_chan_LBDInterPro annotationAdd BLAST215
Domaini243 – 486Neur_chan_membInterPro annotationAdd BLAST244

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
InParanoidiH3B7M9
KOiK04818
OMAiEEWFLVG
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

H3B7M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVVVLLCL SITGVLCRNQ EELLLNKLMR DYNSNLRPAE NEGDIINVTL
60 70 80 90 100
KLTLTNLISL NEIEEALTTN VWIEMTWRDY RLQWNPHEHH NITCLRVPSK
110 120 130 140 150
MVWLPDIVLE NNIDGNFEIT LYINVLVSPN GNIYWLPPAI YRSSCSIIVN
160 170 180 190 200
YFPFDWQNCS LVFRSQTYSA NEIDLQLTVE ENQTIEWIVI DPEDFTENGE
210 220 230 240 250
WAIKHKPAKR LVNDRFTKDD LEYQEVIFYL IIQRKPLFYV INIITPCVLI
260 270 280 290 300
SSIGLLVYFL PAKAGGQKCT LSINVLLAQT VYLFLIAKKV PETSQAVPLI
310 320 330 340 350
VKYLTFLMCM EIIIVMNCVI VLNVSLRTPN THTMSHKVRE LFLKWLPRYL
360 370 380 390 400
GMHLNPSEEV WCAPVPRRKS SLRLIFKADE YMLRKARSEL MFERQKERDG
410 420 430 440 450
LMKAVLQKIG SRLENGTIHD ICYSLSHTAP QIRKCVEACN YIVKSTQEQN
460 470 480 490 500
EFDSENEEWI LVGKVIDRVC FWIIFCVFIC GTVGVFLMAH FNQAPSDPFP

GDPKKYLP
Length:508
Mass (Da):58,854
Last modified:April 18, 2012 - v1
Checksum:i0EF80FEF732B3E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01083700 Genomic DNA No translation available.
AFYH01083701 Genomic DNA No translation available.
AFYH01083702 Genomic DNA No translation available.
AFYH01083703 Genomic DNA No translation available.
RefSeqiXP_005997427.2, XM_005997365.2

Genome annotation databases

EnsembliENSLACT00000018030; ENSLACP00000017900; ENSLACG00000015771
GeneIDi102351763
KEGGilcm:102351763

Similar proteinsi

Entry informationi

Entry nameiH3B7M9_LATCH
AccessioniPrimary (citable) accession number: H3B7M9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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