Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 49 (07 Apr 2021)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

RUN and FYVE domain containing 2

Gene

RUFY2

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri636 – 694FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RUN and FYVE domain containing 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUFY2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7897.ENSLACP00000014460

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 261RUNInterPro annotationAdd BLAST133
Domaini636 – 694FYVE-typeInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili306 – 354Sequence analysisAdd BLAST49
Coiled coili377 – 407Sequence analysisAdd BLAST31
Coiled coili474 – 515Sequence analysisAdd BLAST42
Coiled coili548 – 602Sequence analysisAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri636 – 694FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4381, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155595

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014576_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3AXT9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYCPEAQ

TreeFam database of animal gene trees

More...
TreeFami
TF323904

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.900, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit
PF02759, RUN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit
SM00593, RUN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741, SSF140741, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50826, RUN, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3AXT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSAEQDLT LAEGESNKKE QSFGILRLQE EKAGESRSAS RGGGGGVGDG
60 70 80 90 100
RWQAPIFALA RKASETISGS IPALPKASPA VAASTEHEEW DRKAIKDPMA
110 120 130 140 150
VERANLLNMA KLSIKGLIES ALRFGRTLDS DYPPLQQFFV VMEHCLKHGL
160 170 180 190 200
KVKKSFLGYS KSIWAPMELV EKLCPEAGEI AASVRDLPGL KTPLGRVRAW
210 220 230 240 250
LRLALMQKKL ADYLRCLITR KDLLSDFYDY HALMMEEEGA VIVGLLVGLN
260 270 280 290 300
VIDANLCVKG EDLDSQVGVI DFSLYLRNEE DSYRSEERNG QIAAILDQKN
310 320 330 340 350
YVEELNRQLN STVTSLQARV DSLEKSNTKL IEELAIAKNS IIKLQEENHQ
360 370 380 390 400
LRNENTLILM RTQHQLETAK VDVDAELDTY KQSRQGLDEM YNEARKQLRE
410 420 430 440 450
ESQLRQQKTI DAYLVWDLSI NKENIVFLQN TVKDIHYNTI ITHQQSQGIV
460 470 480 490 500
AIRVVQVQET QGSEDGLSQK NEIISRLEEK TNQITATMKQ LEQRLQQAEK
510 520 530 540 550
GRQAAEDGVR KFKQEFTSKS DSLQKQILKR EKQLLQLETD WKIEKEWRQT
560 570 580 590 600
LQNDLDRERE IISELKTETE QMNGLKKEFL RLQEENTQLK RICEEQEQAL
610 620 630 640 650
QELGFKLSES KLKIEDIKEA NKVLQGGGGG QGWLKDKDAT HCKLCEKEFS
660 670 680 690 700
LSRRKHHCRN CGEIFCNACS DNELPLPSSP KPVRVCDTCH AMLLQRCSSN

ST
Length:702
Mass (Da):79,689
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9C7D80C234FE4ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFYH01022242 Genomic DNA No translation available.
AFYH01022243 Genomic DNA No translation available.
AFYH01022244 Genomic DNA No translation available.
AFYH01022245 Genomic DNA No translation available.
AFYH01022246 Genomic DNA No translation available.
AFYH01022247 Genomic DNA No translation available.
AFYH01022248 Genomic DNA No translation available.
AFYH01022249 Genomic DNA No translation available.
AFYH01022250 Genomic DNA No translation available.
AFYH01022251 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLACT00000014560; ENSLACP00000014460; ENSLACG00000012724

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01022242 Genomic DNA No translation available.
AFYH01022243 Genomic DNA No translation available.
AFYH01022244 Genomic DNA No translation available.
AFYH01022245 Genomic DNA No translation available.
AFYH01022246 Genomic DNA No translation available.
AFYH01022247 Genomic DNA No translation available.
AFYH01022248 Genomic DNA No translation available.
AFYH01022249 Genomic DNA No translation available.
AFYH01022250 Genomic DNA No translation available.
AFYH01022251 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000014460

Genome annotation databases

EnsembliENSLACT00000014560; ENSLACP00000014460; ENSLACG00000012724

Phylogenomic databases

eggNOGiKOG4381, Eukaryota
GeneTreeiENSGT00940000155595
HOGENOMiCLU_014576_3_1_1
InParanoidiH3AXT9
OMAiKYCPEAQ
TreeFamiTF323904

Family and domain databases

Gene3Di1.20.58.900, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF02759, RUN, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00593, RUN, 1 hit
SUPFAMiSSF140741, SSF140741, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50826, RUN, 1 hit
PS50178, ZF_FYVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3AXT9_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3AXT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again