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Entry version 69 (25 May 2022)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

MACF1

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7897.ENSLACP00000013693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 139Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini152 – 258Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini828 – 885SH3InterPro annotationAdd BLAST58
Domaini7075 – 7150GARInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2168 – 2194DisorderedSequence analysisAdd BLAST27
Regioni2792 – 2815DisorderedSequence analysisAdd BLAST24
Regioni2846 – 2866DisorderedSequence analysisAdd BLAST21
Regioni2981 – 3119DisorderedSequence analysisAdd BLAST139
Regioni7193 – 7371DisorderedSequence analysisAdd BLAST179

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 40Sequence analysisAdd BLAST28
Coiled coili437 – 457Sequence analysisAdd BLAST21
Coiled coili462 – 482Sequence analysisAdd BLAST21
Coiled coili689 – 709Sequence analysisAdd BLAST21
Coiled coili1051 – 1071Sequence analysisAdd BLAST21
Coiled coili1157 – 1177Sequence analysisAdd BLAST21
Coiled coili1192 – 1212Sequence analysisAdd BLAST21
Coiled coili1360 – 1387Sequence analysisAdd BLAST28
Coiled coili1454 – 1506Sequence analysisAdd BLAST53
Coiled coili3225 – 3248Sequence analysisAdd BLAST24
Coiled coili3297 – 3328Sequence analysisAdd BLAST32
Coiled coili3399 – 3419Sequence analysisAdd BLAST21
Coiled coili3429 – 3449Sequence analysisAdd BLAST21
Coiled coili3528 – 3555Sequence analysisAdd BLAST28
Coiled coili3563 – 3583Sequence analysisAdd BLAST21
Coiled coili3688 – 3708Sequence analysisAdd BLAST21
Coiled coili3821 – 3841Sequence analysisAdd BLAST21
Coiled coili3938 – 3958Sequence analysisAdd BLAST21
Coiled coili4305 – 4325Sequence analysisAdd BLAST21
Coiled coili4357 – 4387Sequence analysisAdd BLAST31
Coiled coili4533 – 4553Sequence analysisAdd BLAST21
Coiled coili4574 – 4608Sequence analysisAdd BLAST35
Coiled coili4774 – 4801Sequence analysisAdd BLAST28
Coiled coili4846 – 4894Sequence analysisAdd BLAST49
Coiled coili4976 – 4996Sequence analysisAdd BLAST21
Coiled coili5024 – 5044Sequence analysisAdd BLAST21
Coiled coili5050 – 5070Sequence analysisAdd BLAST21
Coiled coili5996 – 6023Sequence analysisAdd BLAST28
Coiled coili6047 – 6074Sequence analysisAdd BLAST28
Coiled coili6266 – 6293Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2990 – 3038Polar residuesSequence analysisAdd BLAST49
Compositional biasi3039 – 3058Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi3073 – 3119Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi7208 – 7311Polar residuesSequence analysisAdd BLAST104
Compositional biasi7318 – 7371Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000015_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3AVM2

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYYQDSC

TreeFam database of animal gene trees

More...
TreeFami
TF335163

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00176, SPEC, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 9 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 16 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3AVM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGFIPGLLP ASLSQEKEFV QAYEDVLERY KDERDRVQKK TFTKWVNKHL
60 70 80 90 100
IKVRKHINDL YEDLRDGHNL ISLLEVLSGV KLPREKGRMR FHRLQNVQIA
110 120 130 140 150
LDFLKQRQVK LVNIRNDDIT DGNPKLTLGL IWTIILHFQI SDIYVSGESG
160 170 180 190 200
DMSAKEKLLL WTQKVTEGYP GIRCTNFTSC WSDGRMFNAL IHRYRPDLID
210 220 230 240 250
MEQVARQSNR ENLEQAFEVA EVLGVTRLLD AEETDVDVPS PDEKSVITYV
260 270 280 290 300
SSIYDVFPKV PEGGDGISAN DIEFKWQEYQ NRVDFLLQWV RQHTILMSEK
310 320 330 340 350
SFPQNPVELK ALYNEYVHFK ETEITAKEEE KGKIEHLYKL LEVWIEFGRV
360 370 380 390 400
KLPQGYHPND LEEEWGKLII EMLEREKALR PAVERLELLL QIANKIQNGA
410 420 430 440 450
LSCEEKLTLA RNTLQADASQ LELGQPLQYE SDVVMYLQEC EGLIRQLQVD
460 470 480 490 500
LKILRDEKYY QVEQLVFRIV QLQDELVTLR LECGNLYRKG QFTASELLRP
510 520 530 540 550
PNMTTTDFCI DRGSNMLHTT SAVWFRKPMT RAELVAISSS EDEGYLRFVY
560 570 580 590 600
ELLAWVEETQ IKLERAEWGS DLPSVETQLE IHQVIHSAVE EQEASLRDLK
610 620 630 640 650
FYESKISPNF RSSYSETLGK LENQFYKLLE TSSLRLRHLK SLHGFVSRAT
660 670 680 690 700
TELIWLNEKE EEELAFDWSD NNPNMPAKRD SFIDLTGELE EKHNVIKSLQ
710 720 730 740 750
ETAEFLSLEN HPAKQTVEAY SAAVQSQWQW VKQLCGCVEQ HVRENTAYFQ
760 770 780 790 800
FFGDARDSET YLRNLQEAIK RKYTCDRGIV LLRLEDLLQD SMDEKEQLIQ
810 820 830 840 850
YKSSVASLVG RAKTIVQLKA RNPDTTLKGT IPIRAVCDYR QIEITIGKND
860 870 880 890 900
ECVLEDNSQR TKWKVISPTG NEAMVPSVCF VIPPPNKEAT ETASRIEQLY
910 920 930 940 950
QNVMSLWHQL HVNMKSVVSW KYLVKDIENV QGWNKQMIKS LSGSERQHTL
960 970 980 990 1000
KSLQGHYEDF LEDSQESQVF SLSDRLQLEQ EVDACKEHAK SLVESMETEE
1010 1020 1030 1040 1050
KDESLTKSYI SELQNIRLRL EDCEQRLVRC VQPPTTKDEA LQDSAICIAE
1060 1070 1080 1090 1100
QERLQEELEG LKSNLGEISD KCESFFYRSP ASTGVPNLRS ELNLAVQKMD
1110 1120 1130 1140 1150
RVYALSSVYL DRLKTVDVVL RNTQGAEAVV QAYEVKLSQE NPVSADLQAI
1160 1170 1180 1190 1200
QAERETLQQW LSNVNEKESV FTDLEDEILK AGEVAERLYR LNNERNHDLE
1210 1220 1230 1240 1250
RYQEKAVQLR DRWQNVHTQI ETRQSELEGI QDLLQCYRES HDSLVQWIEE
1260 1270 1280 1290 1300
MTTQQELMQA GQGEDSKVLS EQLSQQMALV AEIEKNQAKL DECQKYSQQY
1310 1320 1330 1340 1350
STSVKDYELQ LMTYRAFVES QQKSPVKRRR LPSSSDVITQ EFMDLRTRYT
1360 1370 1380 1390 1400
ALVTLMTQQV KYISDALRRL EEEEKVVEEE KHEHMGKVTE LLGWVAGIGK
1410 1420 1430 1440 1450
SLQEKVVQLD GAELEDIERS FSEQQALTGE LSAKKDEIAE AVQSAQLFLA
1460 1470 1480 1490 1500
KHGNKLSEEE RAELTDQLTS LKKRHNQLCS QSTEQLQNLK KKLEHEEEQK
1510 1520 1530 1540 1550
GNKAIAGVID LGTVEIFPVF QAMQNGLIDQ DTGVALLEAQ VTMSGLIVPE
1560 1570 1580 1590 1600
TSETLSLDEA LERNLIDRTT AQSLHELQTA LEVIDQTTFK NKRLLPAVAA
1610 1620 1630 1640 1650
IEEGKIGEDM GLKILETHLA TGGLPAPPKS ERMSLEKALK EDRITAQVYS
1660 1670 1680 1690 1700
KLKTYQKSYK NLIDPNTAEK LNLSDLMQRC IINRETGLKL LPVKQLAGGM
1710 1720 1730 1740 1750
VGLKSGRKVS IFRAVQEGLI DRQVTVRLLE AQLFAGGIVD PRTGHRLTVD
1760 1770 1780 1790 1800
EAVRHGLIDQ DMACALLIRQ LQMSGIIDTV TGQRLSIDEA VNRDLVASRI
1810 1820 1830 1840 1850
ALVILESLWS FMGLLWPESG EILSVADALQ QGIVSSELAH KILQHRQQIR
1860 1870 1880 1890 1900
ALYIPETTEI LSWENAVRHR VLNKDVAEIL SSTLIPDVMP SMKLADSPTL
1910 1920 1930 1940 1950
NRLSWNSAQG SPPCYEDKSF EKDSLTSQSD AAQRLMFHLM THSYVNVHDG
1960 1970 1980 1990 2000
QRLLLVNAEL NDITKDCIEA KVNAKDLEDG KEKSEEMSVE VVTLAEKPSF
2010 2020 2030 2040 2050
LKAAGGEMSL RSLKSQFVYV DEKTKEIEPV HVRVDYSENV QQSDGAYRIT
2060 2070 2080 2090 2100
RKGTERIENP PLAVDDKTMT AMDQKMDLCD EDKTIKALMK APKRSLDAEY
2110 2120 2130 2140 2150
NDQKEDLDHY TILASNSSIS EDTSERKPSK TQISVEVIKP AEDVVDLVAQ
2160 2170 2180 2190 2200
FHSVVMAVNV DGVSGSLSQA NTTQTVEETV KESSKEGRKK KGRKSKIGKA
2210 2220 2230 2240 2250
IPVLELNQNL PELGVKETTD DIMGMYISDE KVRNVKVTTE QENANGMQEF
2260 2270 2280 2290 2300
ITEKPDEENM LDVLTAQLLE GGILDNLTGK KLLLNEAMAK GILQSHTAVK
2310 2320 2330 2340 2350
VMDKLGMFSG FFDSHTCEML NTDDVIDEGL MDEKLVQKIF KSDCTISGVL
2360 2370 2380 2390 2400
DSSRNVICPV QNAADLGLLD RETAKRLLEG QLVNGGIIDL KRGKKVSVTL
2410 2420 2430 2440 2450
ASRLGLVDSA TQEELIKLEK ASKGKGTDET TKHKIIELQS ETSGIVDPRT
2460 2470 2480 2490 2500
KESLNIAQSL ERGLLETKQA FQVLVKQVAD GGIIHSLSGM RLCVADAFNH
2510 2520 2530 2540 2550
GLIDQEMAEE LEDVETACQH QYIHPETKEP VTLLQAASVG LVDPEFAVQM
2560 2570 2580 2590 2600
QEVQALSGSF KDPTTGQKLT LTKAVKQGLL EKQVLDKILG NTEMQHRIVD
2610 2620 2630 2640 2650
PEIAMIVSYS DLVKRGMIDV HSGQRYLEVK PFTGLKNEVT GETIPIAEAA
2660 2670 2680 2690 2700
KAGEVDLVPV LRLLQAQADT EVTQNGTSMK REMATCKLDS SIDNESSNSK
2710 2720 2730 2740 2750
LENMDYIISG EAQSTNTEQE KINSIREVLK MLIRHLYQPR FKLTKEKTMK
2760 2770 2780 2790 2800
GKKEETMFEV ESPPTSTLEN EIKMSQMQDT FVYEISKKES ETLTSKEEGV
2810 2820 2830 2840 2850
KVKPKSKKSK TRMKPKDIIS KRPAEERSGF RVKVVTSKVP ETFGNETRMS
2860 2870 2880 2890 2900
DFTTSQNTQH SDSCKMSQVP VDSLVLDSET DVEMKSEELP FTASNQQIDM
2910 2920 2930 2940 2950
SIFFVKDVLE KGIKDEFYKD VSEPKLKRMQ EQLSLEMLQE GVEQEGEFDT
2960 2970 2980 2990 3000
YYAPLEKVVQ HLRDDSIDLQ EAAKVKNIEE WHEQESQQDA GEEFQNVQHS
3010 3020 3030 3040 3050
QGSQQDVGKE FQNVQHEQES QQETGKEAQN VNYEQESQQE ADNKSHVEQH
3060 3070 3080 3090 3100
EELFQQDVGK RVQEGSYQEA GKKVQNEQDK EQSQQEAGKE NQDGGKEVQS
3110 3120 3130 3140 3150
IQHKQESQEE AVEEQENPVK VKAKECLSTD PLVFLVTKGG GSQEQSTVWS
3160 3170 3180 3190 3200
LKYLPCIESL MKGDCRQFVK PQYLHCLMPF EGFPLPFSHF KKQCLEQDEK
3210 3220 3230 3240 3250
LVAYLSFVLD IEVRLKQLQP VGTNLSALQE QLRQAEALDS ELSNLSEHLS
3260 3270 3280 3290 3300
KELESVNEML AGNTRDVPKQ LLKALRKDCK NLQKSYTSVC DVSRSRLLTL
3310 3320 3330 3340 3350
RNQVESEKDK IKAEHEKLQN QLQDLLNWVS ETRSALQDLD AKEKDDAVNL
3360 3370 3380 3390 3400
KQCVKGFLVS NSVELKDPLS NAKSQLDSSA FAIQFFISEH AQDLTPQQSR
3410 3420 3430 3440 3450
QLLRLLNELQ RSFRELSESV AARSEVLRVK LQEEEKAQHQ KVLREQQAES
3460 3470 3480 3490 3500
RQKLDELATW LAQAERVVTG PQATVANADL SALQKRQNDI RKDLQREMDL
3510 3520 3530 3540 3550
RAASIADVIK ATEEFLEENR GKLSPEELAV IENKLQKAKE QYRALQRSAE
3560 3570 3580 3590 3600
TAQKETETAM TTVVQQESEK AKAAEELEEN RTRITGLLGW INSLSETGPL
3610 3620 3630 3640 3650
ELQGVGPDQN LQAEFTSGLR NGFHEVSDGQ DEMKKMAAEN VTGLNQQYQV
3660 3670 3680 3690 3700
LKARHQALLS QQQEFILATQ SAQAFLDKYG STLSPEEREQ LRSNLEDLRT
3710 3720 3730 3740 3750
QFETSLAQSE TELRQVQALQ EELCKFLKDY GEFESWMVQS ELDLEDMKRG
3760 3770 3780 3790 3800
ESDPHSLRTK LHRQSALSED VISHKGDLRY ITISGQKVLD AARVMSEKKA
3810 3820 3830 3840 3850
GKESTAGLDP SGTSSLVKSK LDDATNRYNE LHSKCNNLGS QMNSLLDRYQ
3860 3870 3880 3890 3900
AFQGVADTLS SWIDGSEEAA KKLLLENIAS DPQNVQAQLE STKVLQGDVA
3910 3920 3930 3940 3950
EHQVQVETLK KTAAALLDTE GDLTVDRDCV RQTTDSLAAR FEDLNRKMSE
3960 3970 3980 3990 4000
RVEKLQMAVA QTQSVQEGLE SLLQWVDGVE KNLSKQTSIP PSAAAVQDML
4010 4020 4030 4040 4050
GKSMKLRHDL ASRKSSLDKI REMTQGLVET ADAKTASVLQ GQLSDLTGRV
4060 4070 4080 4090 4100
GAASRDQRDK EEVLKGLLPK LELHEKLTQE LLQFTESKAK TLAAGNQPDN
4110 4120 4130 4140 4150
DIGHFSMQLK DLNSELSKQR GVLHSVEQLT QELTACSLLS DTAQLEGTVQ
4160 4170 4180 4190 4200
RLSRDFTELG EVVKGREEEA FSCQQQLSEF RALVGSLRAW LKGSEAEMPA
4210 4220 4230 4240 4250
VENSLSSEEL DRRIQKVQVL SEDWAAERAK VQEVNSKGSE LENLIIELTA
4260 4270 4280 4290 4300
PDTKTGVCFR GGTVLSSGGG SSPSVNGYHT CKDLTEIQCD VSDVNHGYES
4310 4320 4330 4340 4350
FGAALRDREE QLSAMLDQMR MAQREASSIL SWLESKEQTL SMLGASPTKP
4360 4370 4380 4390 4400
EAVREQAQQN KAVLAELEQN SEKVEQLKKT LLDLLEKHPD SPEVEMWKKM
4410 4420 4430 4440 4450
LAEINSKWTR ASQMTAERQQ QLEDSANQLT SFQTTAAQLS PWLMEKELMM
4460 4470 4480 4490 4500
SVLGPLSIDP NMLNAQKQQV QFMLKEFGTR RSQYEQLGQA AERMLTSSGD
4510 4520 4530 4540 4550
VTPPCSHVQD QLQTINEKWD QLTERLNSRS GQIDQAIVKS TQYQDLLQNL
4560 4570 4580 4590 4600
TERTKTIGQK LNSQSAISTQ PEAVKQQLEE TSEIRSELEE QKELISEAQA
4610 4620 4630 4640 4650
LCEELAALIG EQYLKDELKK RLEAVILPFQ GLEDTAGERM NRLQTALASS
4660 4670 4680 4690 4700
QQFQQMFDEL RSWLDDKCKK HSRSPPISAK LETLQSQTHE QEEFQKSLNQ
4710 4720 4730 4740 4750
HTGSYEMIVD EGEALLVTVQ PGEEKTALQN QLTTLKAHWD ELSKQTADRH
4760 4770 4780 4790 4800
SKLKDCMQKA QKYKQHVEEL LPWIENCEAK VDELEVTIDS SQLEASLLEA
4810 4820 4830 4840 4850
KSLQHDAEKR RSLLEMLNSA ADILIDASQL DEDDIRDEKA GINQRMDTIT
4860 4870 4880 4890 4900
EQLQAKTDSI EEMSQRLREF QENLKNIEKK LEGAKQQLDI YEVLGPQACS
4910 4920 4930 4940 4950
NRNLDKLRAQ QETLQALESQ VYYLKNLTQG LVQDAPEGSD SSKLLQKLEF
4960 4970 4980 4990 5000
VQQEFGTVKQ KVSECCSSME GKIQGISQLQ SHVREMFSQL ADLDDELDSM
5010 5020 5030 5040 5050
SPVGRDMDSL QSQAEDVRTF FGKLQQLKTD IEASEKECKQ MLEVEGSPEI
5060 5070 5080 5090 5100
QMLKRELEAL NKQSTKLGER GRNRQEQLET TMSRVEEFYD KLKELNCLLT
5110 5120 5130 5140 5150
LAEEGDASQG VVGTEVDTIN QQLADFKTFQ KVQVDPIQPK LQQVNGLGQG
5160 5170 5180 5190 5200
LIQSASKNAD VQGLEHDLEE TNTRWNTLNK KVAERITHLQ EALLHCGKFQ
5210 5220 5230 5240 5250
DALEPLLSWL MDTEDLIANQ KPPSAEYKVV KAQIQEQKLL QRLLDDRKAT
5260 5270 5280 5290 5300
VEIIRAEGGR IAQSAEPADQ EKICKQLQSL SERWDALLGK AAARQNQLED
5310 5320 5330 5340 5350
ILVLAKQFHE AIEPLTDWLT VTEKKLANSE PIGTQTTKIQ QQITRHKALE
5360 5370 5380 5390 5400
EDIEKHSVGV EQAVSMGQSL ELLSSTSDQA ALAERLDSTQ TWYEELRDRC
5410 5420 5430 5440 5450
GRKAALLQQA LDNARIFGED EVEVLNWLME VQDKLSRVSV KDYKQDVLHK
5460 5470 5480 5490 5500
QHTEQLALNE EIVNRRRNVD QAVKNGQALL KQTTGEEVIV IQEKLDSIKT
5510 5520 5530 5540 5550
RYSEITSISS KALKTLEQAL QLATKFQSTH QELCSWLSSV EAELTSNGSQ
5560 5570 5580 5590 5600
SPAGEQIPQF QKRQKELKKE IMEHRLVLDT VNEVSSALLE LVPWRAREGL
5610 5620 5630 5640 5650
DRLVSEANER YKSINDIVAQ RVEQIDAAIQ RSQQYEQAAD AELAWVAETK
5660 5670 5680 5690 5700
RKLTALGPIR LEQDQTTAQL QVQKAFSIDI IRHKDTVDEL LATREEILGT
5710 5720 5730 5740 5750
CGEEQKAILQ EKTDSLVEHY EEVSHLNSER YVRLERAQAL VSQFWETYEE
5760 5770 5780 5790 5800
LSPWIEETRV LILQLPAPAI DHDLLKQQQE DMRNLRELIA EHKPQIDKLV
5810 5820 5830 5840 5850
KIGPQLEELN TEEGMMVREK YTTAGALYAQ IKDEVRQRAI ALDEAVAQSA
5860 5870 5880 5890 5900
QFHDKIEPML ENLGHIVDRL RMAPSIPAEV DKIKEFIGDN KSVAMEQEKL
5910 5920 5930 5940 5950
QPSFEAMKRR GEELISRSQG IDKDPAAKGI QDKLDQMVFF WEDIKARVEE
5960 5970 5980 5990 6000
REIKLLDVLD LAVKFWYDMA ALLTTIKDTQ DIVRDLENPG IDPSIIKQQI
6010 6020 6030 6040 6050
EAAESMKEEM DTLHEELEFL RILGADVIFA CGETEKPEVK KSIDEMNSAW
6060 6070 6080 6090 6100
ENLKKTWKER MDKLEEAMQA AVQYQDALQG MFDWLDNAVI KLCDMSSIGT
6110 6120 6130 6140 6150
DISTVKQQLD EMKEFKMEVY QQQIEMEKLS HQGELLLKKA SDETDQDLIQ
6160 6170 6180 6190 6200
EPLTELRHLW ENLGDKINHR QHKLEAALLA LGQFQHALAE LMAWLTHTEE
6210 6220 6230 6240 6250
LLDAQRPVGS DPKVIEIELA KHHVLKNDVL AHQSTVGTVN KAGQELVESS
6260 6270 6280 6290 6300
SGDDAQSLQS RLDKLNQCWK SVLQKTEERL QQLEMTLQQA QGFHGEIEDF
6310 6320 6330 6340 6350
LHWMIRMESQ LSASKAMGGL PETAREQLNT HLELYKGFMA NEETYRSLLE
6360 6370 6380 6390 6400
KGKMMLLNRD DSSGSNTEQS VGLLEQKWQS LSTKMEERKA KLEDALNLAT
6410 6420 6430 6440 6450
EFQNSLQDFI NWLTQAEQNL NIAPPPSLIL DTVLFQIDEH KVFANEVNSH
6460 6470 6480 6490 6500
REQIIELDKT GNQLKYMSQK QDVVLIKNLL VSMQSRWEKV VQRSVERGRA
6510 6520 6530 6540 6550
LDDARKRAKQ FHEAWKKLVD WLEEAENQLD SELEISKDPD KIKVQLTKHK
6560 6570 6580 6590 6600
EFQKTLGGKQ PVYDTTIRTG RAMKDKASLS DDIQKLDHLL GEVRDKWDTV
6610 6620 6630 6640 6650
CGKSVERQHK LEEALLFSGQ FTDAMQALVD WLYKVEPQLA EDQPVHGDLD
6660 6670 6680 6690 6700
LVMNLMDAHK VFQKELGKRT SSVQALKRSA RDLIENSRDD TTWVKGQLQE
6710 6720 6730 6740 6750
LSTRWDTVCK LSVSKQSRLE QALKQAEDFR TAIHMLLEWL SEAEQTLRFR
6760 6770 6780 6790 6800
GALPDDTEAL QSLIDLHKEF MQKVEEKQVD VNKTAAMGEA ILAVSHPDCF
6810 6820 6830 6840 6850
TTIKHWITII RARFEEVLTW ARQHQQRLAT ALAELVTNAE LLEELLAWIQ
6860 6870 6880 6890 6900
WAETTLIQRD QEPMPQNIEQ VKDLISEHQV RAKSHVHPHT HNPVFTTNIL
6910 6920 6930 6940 6950
KIYQENCALA AFDTNFVFCV PLHTCALRRF KQSDLLPRGA KTTIKASNLS
6960 6970 6980 6990 7000
LVLKLERTRE QYLLALYSHM HKYETERCLR LMPGALRFQV SATKMNFTEH
7010 7020 7030 7040 7050
VIRVCFIYVF IRKLGKSKFV DPIKTSFNGA MMLNRSKILA LFFKDPNSFL
7060 7070 7080 7090 7100
LIYHGVASLN NKYDSYSNIY IKKKNKNKKI IIIFTLKIAS EVEFRDQRKS
7110 7120 7130 7140 7150
KIDSFYPQNK QFGDSQQLRL VRILRSTVMV RVGGGWMALD EFLVKNDPCR
7160 7170 7180 7190 7200
VHYPGNKIIC SDSNTSIASR SPIARGRTNL ELREKFILPE GASQGMAAFR
7210 7220 7230 7240 7250
SRGRRSKPSS RAASPTRSSS SASHSNHSCT SVPSSPATPA SGSKVTPSQG
7260 7270 7280 7290 7300
SKLKRPTYHS SRGSLTGDNG NYASPTSFSA KSGRTDSKKT ATSRPTSRAG
7310 7320 7330 7340 7350
SRTGSRASSR RGSDASDFDL LETQSACSDV SETSAPGSQA GSRRGSTKPS
7360 7370
KIPTMSKKTT TTSPKTPTSK R
Length:7,371
Mass (Da):835,834
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFE90928CA980295
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M3XHJ7M3XHJ7_LATCH
Microtubule actin crosslinking fact...
MACF1
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFYH01066625 Genomic DNA No translation available.
AFYH01066626 Genomic DNA No translation available.
AFYH01066627 Genomic DNA No translation available.
AFYH01066628 Genomic DNA No translation available.
AFYH01066629 Genomic DNA No translation available.
AFYH01066630 Genomic DNA No translation available.
AFYH01066631 Genomic DNA No translation available.
AFYH01066632 Genomic DNA No translation available.
AFYH01066633 Genomic DNA No translation available.
AFYH01066634 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLACT00000013790; ENSLACP00000013693; ENSLACG00000012051

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01066625 Genomic DNA No translation available.
AFYH01066626 Genomic DNA No translation available.
AFYH01066627 Genomic DNA No translation available.
AFYH01066628 Genomic DNA No translation available.
AFYH01066629 Genomic DNA No translation available.
AFYH01066630 Genomic DNA No translation available.
AFYH01066631 Genomic DNA No translation available.
AFYH01066632 Genomic DNA No translation available.
AFYH01066633 Genomic DNA No translation available.
AFYH01066634 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000013693

Genome annotation databases

EnsembliENSLACT00000013790; ENSLACP00000013693; ENSLACG00000012051

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_0_1_1
InParanoidiH3AVM2
OMAiNYYQDSC
TreeFamiTF335163

Family and domain databases

CDDicd00014, CH, 2 hits
cd00176, SPEC, 15 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 9 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 16 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3AVM2_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3AVM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 25, 2022
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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