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UniProtKB - H3AVM2 (H3AVM2_LATCH)

Entry version 69 (25 May 2022)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

MACF1

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Coelacanthiformes › Coelacanthidae › Latimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7897.ENSLACP00000013693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 139Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini152 – 258Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini828 – 885SH3InterPro annotationAdd BLAST58
Domaini7075 – 7150GARInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2168 – 2194DisorderedSequence analysisAdd BLAST27
Regioni2792 – 2815DisorderedSequence analysisAdd BLAST24
Regioni2846 – 2866DisorderedSequence analysisAdd BLAST21
Regioni2981 – 3119DisorderedSequence analysisAdd BLAST139
Regioni7193 – 7371DisorderedSequence analysisAdd BLAST179

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 40Sequence analysisAdd BLAST28
Coiled coili437 – 457Sequence analysisAdd BLAST21
Coiled coili462 – 482Sequence analysisAdd BLAST21
Coiled coili689 – 709Sequence analysisAdd BLAST21
Coiled coili1051 – 1071Sequence analysisAdd BLAST21
Coiled coili1157 – 1177Sequence analysisAdd BLAST21
Coiled coili1192 – 1212Sequence analysisAdd BLAST21
Coiled coili1360 – 1387Sequence analysisAdd BLAST28
Coiled coili1454 – 1506Sequence analysisAdd BLAST53
Coiled coili3225 – 3248Sequence analysisAdd BLAST24
Coiled coili3297 – 3328Sequence analysisAdd BLAST32
Coiled coili3399 – 3419Sequence analysisAdd BLAST21
Coiled coili3429 – 3449Sequence analysisAdd BLAST21
Coiled coili3528 – 3555Sequence analysisAdd BLAST28
Coiled coili3563 – 3583Sequence analysisAdd BLAST21
Coiled coili3688 – 3708Sequence analysisAdd BLAST21
Coiled coili3821 – 3841Sequence analysisAdd BLAST21
Coiled coili3938 – 3958Sequence analysisAdd BLAST21
Coiled coili4305 – 4325Sequence analysisAdd BLAST21
Coiled coili4357 – 4387Sequence analysisAdd BLAST31
Coiled coili4533 – 4553Sequence analysisAdd BLAST21
Coiled coili4574 – 4608Sequence analysisAdd BLAST35
Coiled coili4774 – 4801Sequence analysisAdd BLAST28
Coiled coili4846 – 4894Sequence analysisAdd BLAST49
Coiled coili4976 – 4996Sequence analysisAdd BLAST21
Coiled coili5024 – 5044Sequence analysisAdd BLAST21
Coiled coili5050 – 5070Sequence analysisAdd BLAST21
Coiled coili5996 – 6023Sequence analysisAdd BLAST28
Coiled coili6047 – 6074Sequence analysisAdd BLAST28
Coiled coili6266 – 6293Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2990 – 3038Polar residuesSequence analysisAdd BLAST49
Compositional biasi3039 – 3058Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi3073 – 3119Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi7208 – 7311Polar residuesSequence analysisAdd BLAST104
Compositional biasi7318 – 7371Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000015_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H3AVM2

Identification of Orthologs from Complete Genome Data

More...OMAi		NYYQDSC

TreeFam database of animal gene trees

More...TreeFami		TF335163

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00176, SPEC, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 9 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 16 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3AVM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGFIPGLLP ASLSQEKEFV QAYEDVLERY KDERDRVQKK TFTKWVNKHL 
        60         70         80         90        100
IKVRKHINDL YEDLRDGHNL ISLLEVLSGV KLPREKGRMR FHRLQNVQIA 
       110        120        130        140        150
LDFLKQRQVK LVNIRNDDIT DGNPKLTLGL IWTIILHFQI SDIYVSGESG 
       160        170        180        190        200
DMSAKEKLLL WTQKVTEGYP GIRCTNFTSC WSDGRMFNAL IHRYRPDLID 
       210        220        230        240        250
MEQVARQSNR ENLEQAFEVA EVLGVTRLLD AEETDVDVPS PDEKSVITYV 
       260        270        280        290        300
SSIYDVFPKV PEGGDGISAN DIEFKWQEYQ NRVDFLLQWV RQHTILMSEK 
       310        320        330        340        350
SFPQNPVELK ALYNEYVHFK ETEITAKEEE KGKIEHLYKL LEVWIEFGRV 
       360        370        380        390        400
KLPQGYHPND LEEEWGKLII EMLEREKALR PAVERLELLL QIANKIQNGA 
       410        420        430        440        450
LSCEEKLTLA RNTLQADASQ LELGQPLQYE SDVVMYLQEC EGLIRQLQVD 
       460        470        480        490        500
LKILRDEKYY QVEQLVFRIV QLQDELVTLR LECGNLYRKG QFTASELLRP 
       510        520        530        540        550
PNMTTTDFCI DRGSNMLHTT SAVWFRKPMT RAELVAISSS EDEGYLRFVY 
       560        570        580        590        600
ELLAWVEETQ IKLERAEWGS DLPSVETQLE IHQVIHSAVE EQEASLRDLK 
       610        620        630        640        650
FYESKISPNF RSSYSETLGK LENQFYKLLE TSSLRLRHLK SLHGFVSRAT 
       660        670        680        690        700
TELIWLNEKE EEELAFDWSD NNPNMPAKRD SFIDLTGELE EKHNVIKSLQ 
       710        720        730        740        750
ETAEFLSLEN HPAKQTVEAY SAAVQSQWQW VKQLCGCVEQ HVRENTAYFQ 
       760        770        780        790        800
FFGDARDSET YLRNLQEAIK RKYTCDRGIV LLRLEDLLQD SMDEKEQLIQ 
       810        820        830        840        850
YKSSVASLVG RAKTIVQLKA RNPDTTLKGT IPIRAVCDYR QIEITIGKND 
       860        870        880        890        900
ECVLEDNSQR TKWKVISPTG NEAMVPSVCF VIPPPNKEAT ETASRIEQLY 
       910        920        930        940        950
QNVMSLWHQL HVNMKSVVSW KYLVKDIENV QGWNKQMIKS LSGSERQHTL 
       960        970        980        990       1000
KSLQGHYEDF LEDSQESQVF SLSDRLQLEQ EVDACKEHAK SLVESMETEE 
      1010       1020       1030       1040       1050
KDESLTKSYI SELQNIRLRL EDCEQRLVRC VQPPTTKDEA LQDSAICIAE 
      1060       1070       1080       1090       1100
QERLQEELEG LKSNLGEISD KCESFFYRSP ASTGVPNLRS ELNLAVQKMD 
      1110       1120       1130       1140       1150
RVYALSSVYL DRLKTVDVVL RNTQGAEAVV QAYEVKLSQE NPVSADLQAI 
      1160       1170       1180       1190       1200
QAERETLQQW LSNVNEKESV FTDLEDEILK AGEVAERLYR LNNERNHDLE 
      1210       1220       1230       1240       1250
RYQEKAVQLR DRWQNVHTQI ETRQSELEGI QDLLQCYRES HDSLVQWIEE 
      1260       1270       1280       1290       1300
MTTQQELMQA GQGEDSKVLS EQLSQQMALV AEIEKNQAKL DECQKYSQQY 
      1310       1320       1330       1340       1350
STSVKDYELQ LMTYRAFVES QQKSPVKRRR LPSSSDVITQ EFMDLRTRYT 
      1360       1370       1380       1390       1400
ALVTLMTQQV KYISDALRRL EEEEKVVEEE KHEHMGKVTE LLGWVAGIGK 
      1410       1420       1430       1440       1450
SLQEKVVQLD GAELEDIERS FSEQQALTGE LSAKKDEIAE AVQSAQLFLA 
      1460       1470       1480       1490       1500
KHGNKLSEEE RAELTDQLTS LKKRHNQLCS QSTEQLQNLK KKLEHEEEQK 
      1510       1520       1530       1540       1550
GNKAIAGVID LGTVEIFPVF QAMQNGLIDQ DTGVALLEAQ VTMSGLIVPE 
      1560       1570       1580       1590       1600
TSETLSLDEA LERNLIDRTT AQSLHELQTA LEVIDQTTFK NKRLLPAVAA 
      1610       1620       1630       1640       1650
IEEGKIGEDM GLKILETHLA TGGLPAPPKS ERMSLEKALK EDRITAQVYS 
      1660       1670       1680       1690       1700
KLKTYQKSYK NLIDPNTAEK LNLSDLMQRC IINRETGLKL LPVKQLAGGM 
      1710       1720       1730       1740       1750
VGLKSGRKVS IFRAVQEGLI DRQVTVRLLE AQLFAGGIVD PRTGHRLTVD 
      1760       1770       1780       1790       1800
EAVRHGLIDQ DMACALLIRQ LQMSGIIDTV TGQRLSIDEA VNRDLVASRI 
      1810       1820       1830       1840       1850
ALVILESLWS FMGLLWPESG EILSVADALQ QGIVSSELAH KILQHRQQIR 
      1860       1870       1880       1890       1900
ALYIPETTEI LSWENAVRHR VLNKDVAEIL SSTLIPDVMP SMKLADSPTL 
      1910       1920       1930       1940       1950
NRLSWNSAQG SPPCYEDKSF EKDSLTSQSD AAQRLMFHLM THSYVNVHDG 
      1960       1970       1980       1990       2000
QRLLLVNAEL NDITKDCIEA KVNAKDLEDG KEKSEEMSVE VVTLAEKPSF 
      2010       2020       2030       2040       2050
LKAAGGEMSL RSLKSQFVYV DEKTKEIEPV HVRVDYSENV QQSDGAYRIT 
      2060       2070       2080       2090       2100
RKGTERIENP PLAVDDKTMT AMDQKMDLCD EDKTIKALMK APKRSLDAEY 
      2110       2120       2130       2140       2150
NDQKEDLDHY TILASNSSIS EDTSERKPSK TQISVEVIKP AEDVVDLVAQ 
      2160       2170       2180       2190       2200
FHSVVMAVNV DGVSGSLSQA NTTQTVEETV KESSKEGRKK KGRKSKIGKA 
      2210       2220       2230       2240       2250
IPVLELNQNL PELGVKETTD DIMGMYISDE KVRNVKVTTE QENANGMQEF 
      2260       2270       2280       2290       2300
ITEKPDEENM LDVLTAQLLE GGILDNLTGK KLLLNEAMAK GILQSHTAVK 
      2310       2320       2330       2340       2350
VMDKLGMFSG FFDSHTCEML NTDDVIDEGL MDEKLVQKIF KSDCTISGVL 
      2360       2370       2380       2390       2400
DSSRNVICPV QNAADLGLLD RETAKRLLEG QLVNGGIIDL KRGKKVSVTL 
      2410       2420       2430       2440       2450
ASRLGLVDSA TQEELIKLEK ASKGKGTDET TKHKIIELQS ETSGIVDPRT 
      2460       2470       2480       2490       2500
KESLNIAQSL ERGLLETKQA FQVLVKQVAD GGIIHSLSGM RLCVADAFNH 
      2510       2520       2530       2540       2550
GLIDQEMAEE LEDVETACQH QYIHPETKEP VTLLQAASVG LVDPEFAVQM 
      2560       2570       2580       2590       2600
QEVQALSGSF KDPTTGQKLT LTKAVKQGLL EKQVLDKILG NTEMQHRIVD 
      2610       2620       2630       2640       2650
PEIAMIVSYS DLVKRGMIDV HSGQRYLEVK PFTGLKNEVT GETIPIAEAA 
      2660       2670       2680       2690       2700
KAGEVDLVPV LRLLQAQADT EVTQNGTSMK REMATCKLDS SIDNESSNSK 
      2710       2720       2730       2740       2750
LENMDYIISG EAQSTNTEQE KINSIREVLK MLIRHLYQPR FKLTKEKTMK 
      2760       2770       2780       2790       2800
GKKEETMFEV ESPPTSTLEN EIKMSQMQDT FVYEISKKES ETLTSKEEGV 
      2810       2820       2830       2840       2850
KVKPKSKKSK TRMKPKDIIS KRPAEERSGF RVKVVTSKVP ETFGNETRMS 
      2860       2870       2880       2890       2900
DFTTSQNTQH SDSCKMSQVP VDSLVLDSET DVEMKSEELP FTASNQQIDM 
      2910       2920       2930       2940       2950
SIFFVKDVLE KGIKDEFYKD VSEPKLKRMQ EQLSLEMLQE GVEQEGEFDT 
      2960       2970       2980       2990       3000
YYAPLEKVVQ HLRDDSIDLQ EAAKVKNIEE WHEQESQQDA GEEFQNVQHS 
      3010       3020       3030       3040       3050
QGSQQDVGKE FQNVQHEQES QQETGKEAQN VNYEQESQQE ADNKSHVEQH 
      3060       3070       3080       3090       3100
EELFQQDVGK RVQEGSYQEA GKKVQNEQDK EQSQQEAGKE NQDGGKEVQS 
      3110       3120       3130       3140       3150
IQHKQESQEE AVEEQENPVK VKAKECLSTD PLVFLVTKGG GSQEQSTVWS 
      3160       3170       3180       3190       3200
LKYLPCIESL MKGDCRQFVK PQYLHCLMPF EGFPLPFSHF KKQCLEQDEK 
      3210       3220       3230       3240       3250
LVAYLSFVLD IEVRLKQLQP VGTNLSALQE QLRQAEALDS ELSNLSEHLS 
      3260       3270       3280       3290       3300
KELESVNEML AGNTRDVPKQ LLKALRKDCK NLQKSYTSVC DVSRSRLLTL 
      3310       3320       3330       3340       3350
RNQVESEKDK IKAEHEKLQN QLQDLLNWVS ETRSALQDLD AKEKDDAVNL 
      3360       3370       3380       3390       3400
KQCVKGFLVS NSVELKDPLS NAKSQLDSSA FAIQFFISEH AQDLTPQQSR 
      3410       3420       3430       3440       3450
QLLRLLNELQ RSFRELSESV AARSEVLRVK LQEEEKAQHQ KVLREQQAES 
      3460       3470       3480       3490       3500
RQKLDELATW LAQAERVVTG PQATVANADL SALQKRQNDI RKDLQREMDL 
      3510       3520       3530       3540       3550
RAASIADVIK ATEEFLEENR GKLSPEELAV IENKLQKAKE QYRALQRSAE 
      3560       3570       3580       3590       3600
TAQKETETAM TTVVQQESEK AKAAEELEEN RTRITGLLGW INSLSETGPL 
      3610       3620       3630       3640       3650
ELQGVGPDQN LQAEFTSGLR NGFHEVSDGQ DEMKKMAAEN VTGLNQQYQV 
      3660       3670       3680       3690       3700
LKARHQALLS QQQEFILATQ SAQAFLDKYG STLSPEEREQ LRSNLEDLRT 
      3710       3720       3730       3740       3750
QFETSLAQSE TELRQVQALQ EELCKFLKDY GEFESWMVQS ELDLEDMKRG 
      3760       3770       3780       3790       3800
ESDPHSLRTK LHRQSALSED VISHKGDLRY ITISGQKVLD AARVMSEKKA 
      3810       3820       3830       3840       3850
GKESTAGLDP SGTSSLVKSK LDDATNRYNE LHSKCNNLGS QMNSLLDRYQ 
      3860       3870       3880       3890       3900
AFQGVADTLS SWIDGSEEAA KKLLLENIAS DPQNVQAQLE STKVLQGDVA 
      3910       3920       3930       3940       3950
EHQVQVETLK KTAAALLDTE GDLTVDRDCV RQTTDSLAAR FEDLNRKMSE 
      3960       3970       3980       3990       4000
RVEKLQMAVA QTQSVQEGLE SLLQWVDGVE KNLSKQTSIP PSAAAVQDML 
      4010       4020       4030       4040       4050
GKSMKLRHDL ASRKSSLDKI REMTQGLVET ADAKTASVLQ GQLSDLTGRV 
      4060       4070       4080       4090       4100
GAASRDQRDK EEVLKGLLPK LELHEKLTQE LLQFTESKAK TLAAGNQPDN 
      4110       4120       4130       4140       4150
DIGHFSMQLK DLNSELSKQR GVLHSVEQLT QELTACSLLS DTAQLEGTVQ 
      4160       4170       4180       4190       4200
RLSRDFTELG EVVKGREEEA FSCQQQLSEF RALVGSLRAW LKGSEAEMPA 
      4210       4220       4230       4240       4250
VENSLSSEEL DRRIQKVQVL SEDWAAERAK VQEVNSKGSE LENLIIELTA 
      4260       4270       4280       4290       4300
PDTKTGVCFR GGTVLSSGGG SSPSVNGYHT CKDLTEIQCD VSDVNHGYES 
      4310       4320       4330       4340       4350
FGAALRDREE QLSAMLDQMR MAQREASSIL SWLESKEQTL SMLGASPTKP 
      4360       4370       4380       4390       4400
EAVREQAQQN KAVLAELEQN SEKVEQLKKT LLDLLEKHPD SPEVEMWKKM 
      4410       4420       4430       4440       4450
LAEINSKWTR ASQMTAERQQ QLEDSANQLT SFQTTAAQLS PWLMEKELMM 
      4460       4470       4480       4490       4500
SVLGPLSIDP NMLNAQKQQV QFMLKEFGTR RSQYEQLGQA AERMLTSSGD 
      4510       4520       4530       4540       4550
VTPPCSHVQD QLQTINEKWD QLTERLNSRS GQIDQAIVKS TQYQDLLQNL 
      4560       4570       4580       4590       4600
TERTKTIGQK LNSQSAISTQ PEAVKQQLEE TSEIRSELEE QKELISEAQA 
      4610       4620       4630       4640       4650
LCEELAALIG EQYLKDELKK RLEAVILPFQ GLEDTAGERM NRLQTALASS 
      4660       4670       4680       4690       4700
QQFQQMFDEL RSWLDDKCKK HSRSPPISAK LETLQSQTHE QEEFQKSLNQ 
      4710       4720       4730       4740       4750
HTGSYEMIVD EGEALLVTVQ PGEEKTALQN QLTTLKAHWD ELSKQTADRH 
      4760       4770       4780       4790       4800
SKLKDCMQKA QKYKQHVEEL LPWIENCEAK VDELEVTIDS SQLEASLLEA 
      4810       4820       4830       4840       4850
KSLQHDAEKR RSLLEMLNSA ADILIDASQL DEDDIRDEKA GINQRMDTIT 
      4860       4870       4880       4890       4900
EQLQAKTDSI EEMSQRLREF QENLKNIEKK LEGAKQQLDI YEVLGPQACS 
      4910       4920       4930       4940       4950
NRNLDKLRAQ QETLQALESQ VYYLKNLTQG LVQDAPEGSD SSKLLQKLEF 
      4960       4970       4980       4990       5000
VQQEFGTVKQ KVSECCSSME GKIQGISQLQ SHVREMFSQL ADLDDELDSM 
      5010       5020       5030       5040       5050
SPVGRDMDSL QSQAEDVRTF FGKLQQLKTD IEASEKECKQ MLEVEGSPEI 
      5060       5070       5080       5090       5100
QMLKRELEAL NKQSTKLGER GRNRQEQLET TMSRVEEFYD KLKELNCLLT 
      5110       5120       5130       5140       5150
LAEEGDASQG VVGTEVDTIN QQLADFKTFQ KVQVDPIQPK LQQVNGLGQG 
      5160       5170       5180       5190       5200
LIQSASKNAD VQGLEHDLEE TNTRWNTLNK KVAERITHLQ EALLHCGKFQ 
      5210       5220       5230       5240       5250
DALEPLLSWL MDTEDLIANQ KPPSAEYKVV KAQIQEQKLL QRLLDDRKAT 
      5260       5270       5280       5290       5300
VEIIRAEGGR IAQSAEPADQ EKICKQLQSL SERWDALLGK AAARQNQLED 
      5310       5320       5330       5340       5350
ILVLAKQFHE AIEPLTDWLT VTEKKLANSE PIGTQTTKIQ QQITRHKALE 
      5360       5370       5380       5390       5400
EDIEKHSVGV EQAVSMGQSL ELLSSTSDQA ALAERLDSTQ TWYEELRDRC 
      5410       5420       5430       5440       5450
GRKAALLQQA LDNARIFGED EVEVLNWLME VQDKLSRVSV KDYKQDVLHK 
      5460       5470       5480       5490       5500
QHTEQLALNE EIVNRRRNVD QAVKNGQALL KQTTGEEVIV IQEKLDSIKT 
      5510       5520       5530       5540       5550
RYSEITSISS KALKTLEQAL QLATKFQSTH QELCSWLSSV EAELTSNGSQ 
      5560       5570       5580       5590       5600
SPAGEQIPQF QKRQKELKKE IMEHRLVLDT VNEVSSALLE LVPWRAREGL 
      5610       5620       5630       5640       5650
DRLVSEANER YKSINDIVAQ RVEQIDAAIQ RSQQYEQAAD AELAWVAETK 
      5660       5670       5680       5690       5700
RKLTALGPIR LEQDQTTAQL QVQKAFSIDI IRHKDTVDEL LATREEILGT 
      5710       5720       5730       5740       5750
CGEEQKAILQ EKTDSLVEHY EEVSHLNSER YVRLERAQAL VSQFWETYEE 
      5760       5770       5780       5790       5800
LSPWIEETRV LILQLPAPAI DHDLLKQQQE DMRNLRELIA EHKPQIDKLV 
      5810       5820       5830       5840       5850
KIGPQLEELN TEEGMMVREK YTTAGALYAQ IKDEVRQRAI ALDEAVAQSA 
      5860       5870       5880       5890       5900
QFHDKIEPML ENLGHIVDRL RMAPSIPAEV DKIKEFIGDN KSVAMEQEKL 
      5910       5920       5930       5940       5950
QPSFEAMKRR GEELISRSQG IDKDPAAKGI QDKLDQMVFF WEDIKARVEE 
      5960       5970       5980       5990       6000
REIKLLDVLD LAVKFWYDMA ALLTTIKDTQ DIVRDLENPG IDPSIIKQQI 
      6010       6020       6030       6040       6050
EAAESMKEEM DTLHEELEFL RILGADVIFA CGETEKPEVK KSIDEMNSAW 
      6060       6070       6080       6090       6100
ENLKKTWKER MDKLEEAMQA AVQYQDALQG MFDWLDNAVI KLCDMSSIGT 
      6110       6120       6130       6140       6150
DISTVKQQLD EMKEFKMEVY QQQIEMEKLS HQGELLLKKA SDETDQDLIQ 
      6160       6170       6180       6190       6200
EPLTELRHLW ENLGDKINHR QHKLEAALLA LGQFQHALAE LMAWLTHTEE 
      6210       6220       6230       6240       6250
LLDAQRPVGS DPKVIEIELA KHHVLKNDVL AHQSTVGTVN KAGQELVESS 
      6260       6270       6280       6290       6300
SGDDAQSLQS RLDKLNQCWK SVLQKTEERL QQLEMTLQQA QGFHGEIEDF 
      6310       6320       6330       6340       6350
LHWMIRMESQ LSASKAMGGL PETAREQLNT HLELYKGFMA NEETYRSLLE 
      6360       6370       6380       6390       6400
KGKMMLLNRD DSSGSNTEQS VGLLEQKWQS LSTKMEERKA KLEDALNLAT 
      6410       6420       6430       6440       6450
EFQNSLQDFI NWLTQAEQNL NIAPPPSLIL DTVLFQIDEH KVFANEVNSH 
      6460       6470       6480       6490       6500
REQIIELDKT GNQLKYMSQK QDVVLIKNLL VSMQSRWEKV VQRSVERGRA 
      6510       6520       6530       6540       6550
LDDARKRAKQ FHEAWKKLVD WLEEAENQLD SELEISKDPD KIKVQLTKHK 
      6560       6570       6580       6590       6600
EFQKTLGGKQ PVYDTTIRTG RAMKDKASLS DDIQKLDHLL GEVRDKWDTV 
      6610       6620       6630       6640       6650
CGKSVERQHK LEEALLFSGQ FTDAMQALVD WLYKVEPQLA EDQPVHGDLD 
      6660       6670       6680       6690       6700
LVMNLMDAHK VFQKELGKRT SSVQALKRSA RDLIENSRDD TTWVKGQLQE 
      6710       6720       6730       6740       6750
LSTRWDTVCK LSVSKQSRLE QALKQAEDFR TAIHMLLEWL SEAEQTLRFR 
      6760       6770       6780       6790       6800
GALPDDTEAL QSLIDLHKEF MQKVEEKQVD VNKTAAMGEA ILAVSHPDCF 
      6810       6820       6830       6840       6850
TTIKHWITII RARFEEVLTW ARQHQQRLAT ALAELVTNAE LLEELLAWIQ 
      6860       6870       6880       6890       6900
WAETTLIQRD QEPMPQNIEQ VKDLISEHQV RAKSHVHPHT HNPVFTTNIL 
      6910       6920       6930       6940       6950
KIYQENCALA AFDTNFVFCV PLHTCALRRF KQSDLLPRGA KTTIKASNLS 
      6960       6970       6980       6990       7000
LVLKLERTRE QYLLALYSHM HKYETERCLR LMPGALRFQV SATKMNFTEH 
      7010       7020       7030       7040       7050
VIRVCFIYVF IRKLGKSKFV DPIKTSFNGA MMLNRSKILA LFFKDPNSFL 
      7060       7070       7080       7090       7100
LIYHGVASLN NKYDSYSNIY IKKKNKNKKI IIIFTLKIAS EVEFRDQRKS 
      7110       7120       7130       7140       7150
KIDSFYPQNK QFGDSQQLRL VRILRSTVMV RVGGGWMALD EFLVKNDPCR 
      7160       7170       7180       7190       7200
VHYPGNKIIC SDSNTSIASR SPIARGRTNL ELREKFILPE GASQGMAAFR 
      7210       7220       7230       7240       7250
SRGRRSKPSS RAASPTRSSS SASHSNHSCT SVPSSPATPA SGSKVTPSQG 
      7260       7270       7280       7290       7300
SKLKRPTYHS SRGSLTGDNG NYASPTSFSA KSGRTDSKKT ATSRPTSRAG 
      7310       7320       7330       7340       7350
SRTGSRASSR RGSDASDFDL LETQSACSDV SETSAPGSQA GSRRGSTKPS 
      7360       7370 
KIPTMSKKTT TTSPKTPTSK R
Length:7,371
Mass (Da):835,834
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFE90928CA980295
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M3XHJ7M3XHJ7_LATCH
Microtubule actin crosslinking fact...
MACF1
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AFYH01066625 Genomic DNA No translation available.
AFYH01066626 Genomic DNA No translation available.
AFYH01066627 Genomic DNA No translation available.
AFYH01066628 Genomic DNA No translation available.
AFYH01066629 Genomic DNA No translation available.
AFYH01066630 Genomic DNA No translation available.
AFYH01066631 Genomic DNA No translation available.
AFYH01066632 Genomic DNA No translation available.
AFYH01066633 Genomic DNA No translation available.
AFYH01066634 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSLACT00000013790; ENSLACP00000013693; ENSLACG00000012051

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01066625 Genomic DNA No translation available.
AFYH01066626 Genomic DNA No translation available.
AFYH01066627 Genomic DNA No translation available.
AFYH01066628 Genomic DNA No translation available.
AFYH01066629 Genomic DNA No translation available.
AFYH01066630 Genomic DNA No translation available.
AFYH01066631 Genomic DNA No translation available.
AFYH01066632 Genomic DNA No translation available.
AFYH01066633 Genomic DNA No translation available.
AFYH01066634 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000013693

Genome annotation databases

EnsembliENSLACT00000013790; ENSLACP00000013693; ENSLACG00000012051

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_0_1_1
InParanoidiH3AVM2
OMAiNYYQDSC
TreeFamiTF335163

Family and domain databases

CDDicd00014, CH, 2 hits
cd00176, SPEC, 15 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 9 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF02187, GAS2, 1 hit
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 16 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3AVM2_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3AVM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 25, 2022
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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