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Entry version 38 (02 Dec 2020)
Sequence version 1 (18 Apr 2012)
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Protein

AF-4_C domain-containing protein

Gene

AFF1

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF-4_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7897.ENSLACP00000008252

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini944 – 1214AF-4_CInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 57DisorderedSequence analysisAdd BLAST37
Regioni82 – 197DisorderedSequence analysisAdd BLAST116
Regioni209 – 329DisorderedSequence analysisAdd BLAST121
Regioni394 – 751DisorderedSequence analysisAdd BLAST358
Regioni768 – 949DisorderedSequence analysisAdd BLAST182
Regioni1078 – 1136DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 179PolarSequence analysisAdd BLAST69
Compositional biasi180 – 194PolyampholyteSequence analysisAdd BLAST15
Compositional biasi218 – 242PolarSequence analysisAdd BLAST25
Compositional biasi245 – 259PolyampholyteSequence analysisAdd BLAST15
Compositional biasi264 – 294PolarSequence analysisAdd BLAST31
Compositional biasi414 – 431PolarSequence analysisAdd BLAST18
Compositional biasi432 – 449PolyampholyteSequence analysisAdd BLAST18
Compositional biasi456 – 555PolarSequence analysisAdd BLAST100
Compositional biasi564 – 602PolarSequence analysisAdd BLAST39
Compositional biasi613 – 680PolyampholyteSequence analysisAdd BLAST68
Compositional biasi705 – 727PolarSequence analysisAdd BLAST23
Compositional biasi784 – 852PolyampholyteSequence analysisAdd BLAST69
Compositional biasi1078 – 1099PolarSequence analysisAdd BLAST22
Compositional biasi1106 – 1136PolarSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3AF31

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H3AF31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANAESSTNC LYNEDRNLLR IKERERRNQE APQEKEPFLE STPLFGEPYK
60 70 80 90 100
TNKGDELSSR IQSMLGNYEE VKELISNRSH QNLIGIPKSA VPLTPQGKSD
110 120 130 140 150
RPFFADKTSG VAQHQFHSIT QRPMDPPSST LSSVSCSKQH QKKAPPTEQS
160 170 180 190 200
ASLHSKTYNS SHVGSQAEDH SCSSKESYTS HLPKRGDKHT DLDSSAKFSS
210 220 230 240 250
SLSKLSLLLP SLSPPAEPLS PLHSNQHISS KAYSSNIQGK ACSRAKSPRD
260 270 280 290 300
PDTGLCEKET REPPSSVASL TVAAQPSAQT FPSSLPSKTN TMPKKPTAYV
310 320 330 340 350
RPMDGQDQAP SESPELKPSS EDYHGQTYEN VTDLKANAKA KLSKLKIPSE
360 370 380 390 400
PIEQTLSNEA HCVEEILREM THSWPPPLTA IHTPSTAEPC KFPFPTKEVQ
410 420 430 440 450
PVPSGFIGQK RYDASSKTLP STQQDASMLK DDLQLSDSED SEEERVSEKP
460 470 480 490 500
VPAAVPTSAP SSQPNSVASA HSSVQVSQSS SESDSSSGSE SESESSSSES
510 520 530 540 550
EGNEPTETVT PEPDTPTANK WQLRNWLTKV SQPATSTECL SDSTYSHGPQ
560 570 580 590 600
ESKEQKSNVS QDHPEVKESC SIASSSESRA VPESTPSKNS RQKAPTQSDS
610 620 630 640 650
GSQRRPVDKK HPKKPTKAAV SEEVRGTAKV KSEPVSHRAK DQPATEKPKV
660 670 680 690 700
KTKGRPKSTE KREPKSSTRG QVEKKKHTSS QQPAPKSPFV TDSDKDEAPC
710 720 730 740 750
PPASCSATAP QSHSIVGGRT SSNKPSDKVP EGSHKEKLLP VQDSRLLSPL
760 770 780 790 800
RDTEVSGALV VKIELNLLSR IPQPPGKGQQ KKSSQVDTSE RKKSEPGKEI
810 820 830 840 850
TEKSSSKPHR KRKGEEDEES KACKKLKLSK ESNLSSSHKE VSRTKVSKPS
860 870 880 890 900
CVKDQKELLP LPMSAVPKAT KAAHKRRNGE SHMCNAVSTP NAKDGKSKSS
910 920 930 940 950
RQDPSLSKHK KVKGKHAGHS KSNKETSENH ATPFPVPSLP NGSPKSIRPH
960 970 980 990 1000
LKFEDKQYSV EHNMKEAKKL KHKADAMSDK IGKAFSYLDA AMSFIESGIA
1010 1020 1030 1040 1050
MESDTQIPKS AYTIFSETVD LIKYTMRLKS FVEPSAPTPE KTFAVLCMRC
1060 1070 1080 1090 1100
LSLLYMAMFR YKRETAIKYS RTLSEHFKSS SRAAQAPSPY IARSTGTPSP
1110 1120 1130 1140 1150
LSPMPSPASS GSSQPGSNAS SSNGGGSGSS GSSSNSVSIP QMIHQVASSY
1160 1170 1180 1190 1200
VNITSLFLSA HDTWEQADAL AKKNKEFFVE LNAVMGCLAL NSSMTELVHY
1210
TRQGLHWLRL DTSMP
Length:1,215
Mass (Da):132,249
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7E3CF9BC327F752
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3AF32H3AF32_LATCH
AF-4_C domain-containing protein
AFF1
965Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFYH01184525 Genomic DNA No translation available.
AFYH01184526 Genomic DNA No translation available.
AFYH01184527 Genomic DNA No translation available.
AFYH01184528 Genomic DNA No translation available.
AFYH01184529 Genomic DNA No translation available.
AFYH01184530 Genomic DNA No translation available.
AFYH01184531 Genomic DNA No translation available.
AFYH01184532 Genomic DNA No translation available.
AFYH01184533 Genomic DNA No translation available.
AFYH01184534 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLACT00000008318; ENSLACP00000008252; ENSLACG00000007303

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01184525 Genomic DNA No translation available.
AFYH01184526 Genomic DNA No translation available.
AFYH01184527 Genomic DNA No translation available.
AFYH01184528 Genomic DNA No translation available.
AFYH01184529 Genomic DNA No translation available.
AFYH01184530 Genomic DNA No translation available.
AFYH01184531 Genomic DNA No translation available.
AFYH01184532 Genomic DNA No translation available.
AFYH01184533 Genomic DNA No translation available.
AFYH01184534 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000008252

Genome annotation databases

EnsembliENSLACT00000008318; ENSLACP00000008252; ENSLACG00000007303

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiH3AF31
OMAiYMAMFRY
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3AF31_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3AF31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: December 2, 2020
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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