UniProtKB - H3ACD8 (H3ACD8_LATCH)
Protein
ALX homeobox protein 1
Gene
ALX1
Organism
Latimeria chalumnae (Coelacanth)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 132 – 191 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- embryonic cranial skeleton morphogenesis Source: Ensembl
- neural crest cell migration Source: Ensembl
Keywordsi
Molecular function | Developmental proteinPROSITE-ProRule annotationARBA annotation, DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ALX homeobox protein 1ARBA annotationAlternative name(s): Cartilage homeoprotein 1ARBA annotation |
Gene namesi | Name:ALX1Imported |
Organismi | Latimeria chalumnae (Coelacanth)Imported |
Taxonomic identifieri | 7897 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Coelacanthiformes › Coelacanthidae › Latimeria |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 190 | HomeoboxInterPro annotationAdd BLAST | 61 | |
Domaini | 306 – 319 | OARInterPro annotationAdd BLAST | 14 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 306 – 319 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the paired homeobox family.ARBA annotation
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | H3ACD8 |
OMAi | PPCVTSY |
TreeFami | TF350743 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
H3ACD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFLSEKFAL KSQSSKSNDL YMGAGGTLEQ VMESLESDSF YNKSSPKCVQ
60 70 80 90 100
AYSAIQRNEH HLTLERTSPC ENNNDVTYGI TKLDNQPLHT ELNRPMENCC
110 120 130 140 150
NLRVSSGKGM QESGELDELA EKCDSNVSSS KKRRHRTTFT SLQLEELEKV
160 170 180 190 200
FQKTHYPDVY VREQLALRTE LTEARVQVWF QNRRAKWRKR ERYGQIQQAK
210 220 230 240 250
SHFAATYDIS VLPRPDNYSQ IQNNLWTGNT SSGSVVTSCM LPRDTSSCMT
260 270 280 290 300
PYSHSSRTDS SFNGFSNHQT QFSHVSLNNF FTDSLLSGAP NGHAFEVKPE
310 320
FERKSSSIAV LRMKAKEHTA NISWAM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AFYH01160098 Genomic DNA No translation available. AFYH01160099 Genomic DNA No translation available. AFYH01160100 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSLACT00000007369; ENSLACP00000007309; ENSLACG00000006482 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AFYH01160098 Genomic DNA No translation available. AFYH01160099 Genomic DNA No translation available. AFYH01160100 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7897.ENSLACP00000007309 |
Genome annotation databases
Ensembli | ENSLACT00000007369; ENSLACP00000007309; ENSLACG00000006482 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000158251 |
HOGENOMi | CLU_047013_0_1_1 |
InParanoidi | H3ACD8 |
OMAi | PPCVTSY |
TreeFami | TF350743 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR033209, ALX1 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003654, OAR_dom |
PANTHERi | PTHR24329:SF359, PTHR24329:SF359, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H3ACD8_LATCH | |
Accessioni | H3ACD8Primary (citable) accession number: H3ACD8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |