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Protein

Importin subunit alpha

Gene

KPNA1

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alphaUniRule annotation
Gene namesi
Name:KPNA1Imported
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)Imported
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi
  • UP000008672 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi7897.ENSLACP00000005797

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57IBBInterPro annotationAdd BLAST57
Repeati126 – 169ARMPROSITE-ProRule annotationAdd BLAST44
Repeati169 – 197ARMPROSITE-ProRule annotationAdd BLAST29
Repeati211 – 239ARMPROSITE-ProRule annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 41Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the importin alpha family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
InParanoidiH3A826
KOiK15042
OMAiSWLLFVN
OrthoDBiEOG091G095Z
TreeFamiTF354205

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 8 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

H3A826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSGKENLW QKRYKNKSLN ADEMRRRREE EGLQLRKQKR EEQLFKRRNV
60 70 80 90 100
ASAEEEPVEE VMSDGGLHES QINNMDMVLS GAITPDMIQM IFSSSPEQQL
110 120 130 140 150
AATQKFRKLL SKEPNPPIDE VINTPGVVAR FVEFLKRREN CTLQFEAAWV
160 170 180 190 200
LTNIASGNSH QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS
210 220 230 240 250
TMCRDYVLEC NILPSLIQLL SKQNRLTMTR NAVWALSNLC RGKHPPPDFA
260 270 280 290 300
LVSPCLSVLS WLLFVNDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR
310 320 330 340 350
LVELLMHCDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLGSP
360 370 380 390 400
KESIKKEACW TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA
410 420 430 440 450
AWAITNATSG GSAEQIKYLV ELSCIKPLCD LLTVMDSRIV QVALNGLENI
460 470 480 490 500
LRLGEQEAKR SGSGINPYCA LIEEAYGLDK IEFLQSHENQ EIYQKAFDLI
510 520 530
EHYFGPEEED SSLAPQVDLG QQQYIFQQCD APMEGFQL
Length:538
Mass (Da):60,166
Last modified:May 1, 2013 - v2
Checksum:i7F05678B10C05D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01186957 Genomic DNA No translation available.
AFYH01186958 Genomic DNA No translation available.
AFYH01186959 Genomic DNA No translation available.
RefSeqiXP_006007811.1, XM_006007749.2
XP_006007812.1, XM_006007750.2
XP_014351118.1, XM_014495632.1

Genome annotation databases

EnsembliENSLACT00000005847; ENSLACP00000005797; ENSLACG00000005146
GeneIDi102362537
KEGGilcm:102362537

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01186957 Genomic DNA No translation available.
AFYH01186958 Genomic DNA No translation available.
AFYH01186959 Genomic DNA No translation available.
RefSeqiXP_006007811.1, XM_006007749.2
XP_006007812.1, XM_006007750.2
XP_014351118.1, XM_014495632.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000005797

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSLACT00000005847; ENSLACP00000005797; ENSLACG00000005146
GeneIDi102362537
KEGGilcm:102362537

Organism-specific databases

CTDi3836

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
InParanoidiH3A826
KOiK15042
OMAiSWLLFVN
OrthoDBiEOG091G095Z
TreeFamiTF354205

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 8 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits
PS51214 IBB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH3A826_LATCH
AccessioniPrimary (citable) accession number: H3A826
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 36 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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