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UniProtKB - H2ZZM8 (H2ZZM8_LATCH)

Entry version 59 (07 Apr 2021)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene

GATA6

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, DNA-bindingARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GATA6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Coelacanthiformes › Coelacanthidae › Latimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7897.ENSLACP00000002849

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 346GATA-typeInterPro annotationAdd BLAST55
Domaini346 – 399GATA-typeInterPro annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 68DisorderedSequence analysisAdd BLAST68
Regioni169 – 229DisorderedSequence analysisAdd BLAST61
Regioni390 – 469DisorderedSequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 33PolarSequence analysisAdd BLAST33
Compositional biasi47 – 61PolarSequence analysisAdd BLAST15
Compositional biasi408 – 469PolarSequence analysisAdd BLAST62

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1601, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160814

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027524_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H2ZZM8

Identification of Orthologs from Complete Genome Data

More...OMAi		ENSMLHC

Database of Orthologous Groups

More...OrthoDBi		807790at2759

TreeFam database of animal gene trees

More...TreeFami		TF315391

Family and domain databases

Conserved Domains Database

More...CDDi		cd00202, ZnF_GATA, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.50.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008013, GATA_N
IPR028437, TF_GATA_6
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...PANTHERi		PTHR10071, PTHR10071, 1 hit
PTHR10071:SF23, PTHR10071:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00320, GATA, 2 hits
PF05349, GATA-N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00619, GATAZNFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00401, ZnF_GATA, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 2 hits
PS50114, GATA_ZN_FINGER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2ZZM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLNDPNWSM VKQLTSNSPG SSPAGQNYLK FTASDTRERP DSESQEDLRS 
        60         70         80         90        100
SATNLDTERN QPPEGRSLDS YVHFGQHNPV SNSEDITLFT DLDQATKLIV 
       110        120        130        140        150
STRDSKGGLV VNHPSEMYQS LAMAATQGPA AYDASAGSFM HSTASSPVYV 
       160        170        180        190        200
PTTRVGSMIS TIPYLQGSGV TQPSHPVSNH WSQPTAESPS YSSGSPHASN 
       210        220        230        240        250
RFPYSPSPPM VNGSSRDGSY SNTLNMNGRD QYSSLARPLT GSYPSPYTPY 
       260        270        280        290        300
VGPQLTTAWA AGPFENSMLH SLQTRAAPIP LRGPNGDVLD ELSESRECVN 
       310        320        330        340        350
CGSIQTPLWR RDGTGHFLCN ACGLYSKMNG LSRPLIKPQK RMSSSRRIGL 
       360        370        380        390        400
SCANCHTTTT TLWRRNAEGE PVCNACGLYM KLHGVPRPLA MKKEGIQTRK 
       410        420        430        440        450
RKPKNINKSK TSSGSSNPVP MTPTSTSSTN SDDCSKTGSL TVQTTASGAS 
       460        470        480        490        500
SSAMTGQGES SSPETSALKY SGQEGLYGGV SLTSTAEAAA SVRQDSWCAL 

ALA
Length:503
Mass (Da):53,693
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B12927D7AA32F46
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AFYH01067582 Genomic DNA No translation available.
AFYH01067583 Genomic DNA No translation available.
AFYH01067584 Genomic DNA No translation available.
AFYH01067585 Genomic DNA No translation available.
AFYH01067586 Genomic DNA No translation available.
AFYH01067587 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_005995770.1, XM_005995708.2
XP_014343723.1, XM_014488237.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSLACT00000002871; ENSLACP00000002849; ENSLACG00000002547

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102345745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		lcm:102345745

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01067582 Genomic DNA No translation available.
AFYH01067583 Genomic DNA No translation available.
AFYH01067584 Genomic DNA No translation available.
AFYH01067585 Genomic DNA No translation available.
AFYH01067586 Genomic DNA No translation available.
AFYH01067587 Genomic DNA No translation available.
RefSeqiXP_005995770.1, XM_005995708.2
XP_014343723.1, XM_014488237.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000002849

Genome annotation databases

EnsembliENSLACT00000002871; ENSLACP00000002849; ENSLACG00000002547
GeneIDi102345745
KEGGilcm:102345745

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2627

Phylogenomic databases

eggNOGiKOG1601, Eukaryota
GeneTreeiENSGT00940000160814
HOGENOMiCLU_027524_0_0_1
InParanoidiH2ZZM8
OMAiENSMLHC
OrthoDBi807790at2759
TreeFamiTF315391

Family and domain databases

CDDicd00202, ZnF_GATA, 2 hits
Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013, GATA_N
IPR028437, TF_GATA_6
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA
PANTHERiPTHR10071, PTHR10071, 1 hit
PTHR10071:SF23, PTHR10071:SF23, 1 hit
PfamiView protein in Pfam
PF00320, GATA, 2 hits
PF05349, GATA-N, 1 hit
PRINTSiPR00619, GATAZNFINGER
SMARTiView protein in SMART
SM00401, ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 2 hits
PS50114, GATA_ZN_FINGER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2ZZM8_LATCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2ZZM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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