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Entry version 50 (07 Oct 2020)
Sequence version 1 (18 Apr 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Ciona savignyi (Pacific transparent sea squirt)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCiona savignyi (Pacific transparent sea squirt)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51511 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007875 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
51511.ENSCSAVP00000009815

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini258 – 316PHD-typeInterPro annotationAdd BLAST59
Domaini261 – 314RING-typeInterPro annotationAdd BLAST54
Domaini892 – 960R3HInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni132 – 233DisorderedSequence analysisAdd BLAST102
Regioni1007 – 1111DisorderedSequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20PolyampholyteSequence analysisAdd BLAST20
Compositional biasi165 – 204PolyampholyteSequence analysisAdd BLAST40
Compositional biasi215 – 233PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1007 – 1042PolarSequence analysisAdd BLAST36
Compositional biasi1050 – 1064PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1090 – 1105PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1952, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005714_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
H2YWV4

Identification of Orthologs from Complete Genome Data

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OMAi
HPCEHPP

TreeFam database of animal gene trees

More...
TreeFami
TF105889

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02643, R3H_NF-X1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING

The PANTHER Classification System

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PANTHERi
PTHR12360, PTHR12360, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00393, R3H, 1 hit
SM00438, ZnF_NFX, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82708, SSF82708, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51061, R3H, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2YWV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDFRGPPER RQDGSSQSRQ ERRQPRGFIP PHGVSNQAEQ FQPNVAEFYS
60 70 80 90 100
NSTAGYLPPD LHYDGRGYET PNLFYPAEFA NQPTYFGPNY MMAGTTTYPG
110 120 130 140 150
TSMPHAFESP GFYADDMTAH FTENQHYQTM LPDNSSAAGK SRRFSRQRNI
160 170 180 190 200
KESGTSGEMY NPKLTAEDCR PHKNDRRSHQ FKQPIRFSHQ KENQNGKKTE
210 220 230 240 250
NIKDPGSKNT QAKGMNESKP EEKAPKSFSR TKGKKVEVMK YDGGNQASVL
260 270 280 290 300
HEQLSSGTYE CMVCCDRVRP PQAVWSCMIC YNVFHMGCIK KWARSPAAKV
310 320 330 340 350
GGTEDSGWRC PGCQNVSAKI PASYLCFCGK VKEPEYKKGE MPHSCGDLCG
360 370 380 390 400
KARRNNPDCA HPCNILCHPG PCPQFPAMVT KRCKCGKISS RVRCSQQKSL
410 420 430 440 450
ACNEVCGKNK NCSNHSCDVV CHSGDCDPCH VKIKQACYCG LEDREVGCGS
460 470 480 490 500
EEHRSQPNDT ENGCYSCTNI CNRVLSCGNH NCSSVCHPGP CKPCSLLPSL
510 520 530 540 550
VTRCPCSQTK LSDMQIDDGE EINRKSCLDP VPTCDKICGK PLLCGGEDVH
560 570 580 590 600
VCKQLCHTGP CSPCSDGEST IVCRCRKSEK DVPCTEFVEM DSYVCDRRCN
610 620 630 640 650
KKRKCGKHKC GQMCCTDTEH NCLQLCGRKL TCGNHRCDET CHRGACHTCY
660 670 680 690 700
NVSFDELRCF CNDKVIFPPI PCGMKAPECN KICSRMHPCT HPVRHSCHTE
710 720 730 740 750
EHCPPCVELV KKTCNCGRTI RGNIMCHIDN VSCGAPCFKV LACGHKCLRP
760 770 780 790 800
CHKGMCIEDV EPCKQPCSIM RVECIHPCAN PCHHGTACPT TPCKAMVTMK
810 820 830 840 850
CECSRREEQV VCSAGGAIYQ SVSSAAFASK QDGVINIDKI LQTSGLPCDE
860 870 880 890 900
ECSVAARNKR FADALNITDA EYGSRPKQQY SEFLINMAKS DLAFIRTVEK
910 920 930 940 950
DLINLVESVG WLDVTKQSHT FPVMRREKRQ AVHELADAFQ CRSESLDVEP
960 970 980 990 1000
NRSVVATATK SVSKQPTPLL SDVIMEQVTS EKVYSSSKQA QSKGRVLSSV
1010 1020 1030 1040 1050
KLVSFNSASS DSTSRPVLTR KSTASGASGP SLKSSLNRPE ISRSTLHRPA
1060 1070 1080 1090 1100
YAPDGRKEAV RIPPKVAPEH ATGSRQEVKP SATKYAPPHQ RSAPATNTTK
1110
SKVIDYFDMS D
Length:1,111
Mass (Da):122,840
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF9628635F886FC3
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCSAVT00000009933; ENSCSAVP00000009815; ENSCSAVG00000005762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi51511.ENSCSAVP00000009815

Genome annotation databases

EnsembliENSCSAVT00000009933; ENSCSAVP00000009815; ENSCSAVG00000005762

Phylogenomic databases

eggNOGiKOG1952, Eukaryota
GeneTreeiENSGT00940000156325
HOGENOMiCLU_005714_1_1_1
InParanoidiH2YWV4
OMAiHPCEHPP
TreeFamiTF105889

Family and domain databases

CDDicd02643, R3H_NF-X1, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
PANTHERiPTHR12360, PTHR12360, 1 hit
PfamiView protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 6 hits
SMARTiView protein in SMART
SM00393, R3H, 1 hit
SM00438, ZnF_NFX, 9 hits
SUPFAMiSSF82708, SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061, R3H, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2YWV4_CIOSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2YWV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 7, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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