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Entry version 53 (07 Oct 2020)
Sequence version 3 (17 Jun 2020)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC101065456

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC101065456Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31033 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
31033.ENSTRUP00000046345

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini680 – 776ELM2InterPro annotationAdd BLAST97
Domaini791 – 842SANTInterPro annotationAdd BLAST52
Domaini957 – 984C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65
Regioni172 – 192DisorderedSequence analysisAdd BLAST21
Regioni221 – 240DisorderedSequence analysisAdd BLAST20
Regioni300 – 322DisorderedSequence analysisAdd BLAST23
Regioni349 – 441DisorderedSequence analysisAdd BLAST93
Regioni492 – 518DisorderedSequence analysisAdd BLAST27
Regioni531 – 570DisorderedSequence analysisAdd BLAST40
Regioni634 – 658DisorderedSequence analysisAdd BLAST25
Regioni866 – 899DisorderedSequence analysisAdd BLAST34
Regioni924 – 956DisorderedSequence analysisAdd BLAST33
Regioni971 – 1049DisorderedSequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 240PolarSequence analysisAdd BLAST17
Compositional biasi353 – 373PolarSequence analysisAdd BLAST21
Compositional biasi413 – 434PolarSequence analysisAdd BLAST22
Compositional biasi531 – 563PolyampholyteSequence analysisAdd BLAST33
Compositional biasi634 – 648Pro-richSequence analysisAdd BLAST15
Compositional biasi873 – 891PolyampholyteSequence analysisAdd BLAST19
Compositional biasi974 – 1001PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1019 – 1034PolarSequence analysisAdd BLAST16
Compositional biasi1035 – 1049AcidicSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4167, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011395_1_0_1

TreeFam database of animal gene trees

More...
TreeFami
TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448, ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2VAV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPPQVNTD KSGKHRGAAM KEPVQHSGEV YYGMGPPAME VTHPDSASSS
60 70 80 90 100
GVYNPEKGPQ SLPHYQQPAP VKWMHQEPMQ APGWSQETPQ SAWGQNFSPY
110 120 130 140 150
MSGVNSRGQM PFHKGVHEGG TLSVGGDNQL PANVEAYRDA SQPQAQGRGL
160 170 180 190 200
EWEQHAMAAM HQAQLQAYQH SHKGVDLQGQ PHVPSHTLQG SIPQPFQAMF
210 220 230 240 250
RPSKQFSSGY YSLFPGNKGV RNMSYGEQPK SQQQLLHQMQ QQQIHQQQQQ
260 270 280 290 300
QQQQQLHQQH QIQLQQQIQQ QQMQQQYHHQ QQQQQQQQQL QERQQHFQQM
310 320 330 340 350
QQLQKQNVPQ QDTTQLQVQP KLQQSQNYAN YQPPDPGPPV TMPVKADVQS
360 370 380 390 400
LETRQEADGQ MCDASSVSNP CSEKFLAHPT EPSDVPLAAP RRSRRLSREG
410 420 430 440 450
QSPLGPPPMN IWPQESKETS QNGAESQAAT GGVIQITSRR RRASKEINLE
460 470 480 490 500
TLAQQASKME PAKLTKEDAV TGRQAMMLPL IMPVSVPVHR IQPDNHGNWG
510 520 530 540 550
PGRLGPGEQP AGPSDRKPSV IVARRRSLRN SITESFGHDE ETNPGLDEDG
560 570 580 590 600
KSKFKRRPRP EPLIIPPHKP STFIPPSLYS TISSYQSNLR SPVRLPEHPA
610 620 630 640 650
ALPPYTPPPI LSPMREGSGL YCSTFLANIA SNQSLPPPPL PLPPPTPKSA
660 670 680 690 700
TRSLLRSASS EVTPPVLPLI TDATPVSLEP RINIGERYQA EIPTLQEQHN
710 720 730 740 750
SQFDQHKADL VWQPADESHL KPGEQQSRQY HVEELMSMAC SSVLRGGGTN
760 770 780 790 800
QELVLHCLHE CGGDILETLE RLMLRDPLFP RGHRLAGYHY SGCDCWTAEE
810 820 830 840 850
KRYFNKGISA YRKDFFMVQK LVQSKTVAQC VEFYYTYKRQ VKIGRNGILT
860 870 880 890 900
FGPPESPAEK QLDAVVDEKN SQLSKLPEAD DHKDGASDRG LDSSHQARVA
910 920 930 940 950
QSLQAHDYAG TMVMIKEPTV AIKETPPLTA APRPRPAPAA KKSKEPTKPP
960 970 980 990 1000
QDTDAVFPCK KCSRVFYKVK SRSAHMKSHA EQEKKAAALR QKEEEEQAAA
1010 1020 1030 1040
VARARKAAAA AASAAEFQRE NGSGVTPQAD VSGQEDSSEV EDDDDEDWH
Length:1,049
Mass (Da):116,752
Last modified:June 17, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i770B04A10886A686
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTRUT00000046502; ENSTRUP00000046345; ENSTRUG00000018103

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000046345

Genome annotation databases

EnsembliENSTRUT00000046502; ENSTRUP00000046345; ENSTRUG00000018103

Phylogenomic databases

eggNOGiKOG4167, Eukaryota
GeneTreeiENSGT00940000157459
HOGENOMiCLU_011395_1_0_1
TreeFamiTF106431

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2VAV3_TAKRU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2VAV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: June 17, 2020
Last modified: October 7, 2020
This is version 53 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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