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Entry version 34 (31 Jul 2019)
Sequence version 2 (05 Dec 2018)
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Protein

UDENN domain-containing protein

Gene

madd

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDENN domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:maddImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31033 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 525UDENNInterPro annotationAdd BLAST513

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni568 – 596DisorderedSequence analysisAdd BLAST29
Regioni638 – 675DisorderedSequence analysisAdd BLAST38
Regioni724 – 802DisorderedSequence analysisAdd BLAST79
Regioni840 – 881DisorderedSequence analysisAdd BLAST42
Regioni993 – 1047DisorderedSequence analysisAdd BLAST55
Regioni1062 – 1199DisorderedSequence analysisAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi657 – 675PolarSequence analysisAdd BLAST19
Compositional biasi753 – 770PolarSequence analysisAdd BLAST18
Compositional biasi785 – 802PolarSequence analysisAdd BLAST18
Compositional biasi860 – 881PolarSequence analysisAdd BLAST22
Compositional biasi1006 – 1025PolarSequence analysisAdd BLAST20
Compositional biasi1085 – 1141PolarSequence analysisAdd BLAST57
Compositional biasi1158 – 1182PolarSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3570 Eukaryota
ENOG410XP23 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2UY17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKKMCPRL LDYLVVVGAR QPSSDSFAQT PQLLRRYPLE DHHDFPLPPD
60 70 80 90 100
VVFFCQPEGC LSIRQRRVSL RDDSSFVFTL TDKDSGITRY GICVNFYRSF
110 120 130 140 150
QREEGGGQLG GEQNAGKSPQ HRRSTAKMAA RNRYSTLTSL CILSHYPFFS
160 170 180 190 200
TFRECLYILK RLVDCCSQRL TQRAGLPRAT QRDTMWRVFT GALSVEEKGS
210 220 230 240 250
QLLADLREIE SWMYRLLRSP VPVAGQRRVD VEVLPHELKR ALTFALPENS
260 270 280 290 300
RFCLVDFPLH LPLELLGVDA CLQVLSCVLL EHKVILQSRD YNALSMSVMA
310 320 330 340 350
FVAMIYPLEY MFPVIPLLPT CMASAEQLLL APTPYIIGVP ASFFLYKAEF
360 370 380 390 400
KIPDDVWLVD LDSSKVIAPT NAEILPPLPE PEAMELKKHL KQALASMSMN
410 420 430 440 450
TQPILNLEKF QEGQELPLLP PGRDKASPSS TEFNPLIYGN DVDSVDVATR
460 470 480 490 500
VAMVRFFNSS NVLQGFQMHT RTLRLFPRPV VAFRSSSFLA SRPRRSSFAD
510 520 530 540 550
KLSHTQAVEF FGEWALNPSN LAFQRIHNNV YDPSLIGDKP KWYAHQLQPV
560 570 580 590 600
VYRVYDGSSQ LVEAMAGPLE DDGNESDPTD SGSDSDAYDD SSSSYSSLGD
610 620 630 640 650
LVSEMIQGDI HGDTTSLDPP THAALGDASE VEFQDFREVN HGCDGPPSEE
660 670 680 690 700
GTGEPSDGQP LRSSSSTTAS SSPSTIIQGV NHELEAPEME ASASAALQNP
710 720 730 740 750
VPALCSQPFL RPPADAGLVE PAGKKQEYDN PYFEPQYGFP SEDDPDAEEQ
760 770 780 790 800
VETYTPRFNQ NLSDNKAQRP LRPSSLRLPG ESDGEGDSRN SSPNSTISNS
810 820 830 840 850
SNDGFGGLMS FASNLYKNHG TSFSLSNLAL PNKAARDKAT PFPSLKGARA
860 870 880 890 900
PRALVDQKSS VIKHSPTVKR ESPSPQGRVN NTSENQQFLK EVVQSVLDGQ
910 920 930 940 950
GVGWLNMKKV RRLLENEQLR LFVLSKLNRA VHTEEDARQE IIRDVEVSRK
960 970 980 990 1000
VYKGMLDILK CTVSSLEHSY TNAGLGGMAS VFSLLEIART HYQTKDPEKR
1010 1020 1030 1040 1050
KRSPTDSVGS PGSKESPSAR AETSRPQGFL NVPHLQLPHH TTGRGARHFD
1060 1070 1080 1090 1100
TRSLNEENFI ASIGSEGAKQ QRPLVADAEE KKSQISADSG LSVTSGSQKS
1110 1120 1130 1140 1150
DTESITSSEP PALTRSTSQD SEASTVISNS SGETLGADSD LSSTAGDGPA
1160 1170 1180 1190 1200
GRIAPHLNQS RGTLSDSEIE TNPATSTVFG KTHTLKPGIK DHSHTLAKGQ
1210 1220 1230 1240 1250
PAQPLEDISM RIYLCEGLLG KERSTLWDQL QFWEDAFLDA VMLEREGMGM
1260 1270 1280 1290 1300
DQGPQEMIER YLSLGDHDRK RLEDDEDRLL ATLLHNMIAY MLMMKLNKND
1310 1320 1330 1340 1350
IRKKVRRLMG KSHIGLTYSQ EINEILDKLA DMNGRELPIR PSGSRHIKKQ
1360 1370 1380 1390 1400
TFVVHAGTDT TGDIFFMEVC DDCIVLRSNI GTVYERWWYE KLINMTYCPK
1410 1420 1430 1440 1450
TKVLCLWRRN GQETQLNKFY TKKCRELYYC VKDSMERAAA RQQSIKPGPE
1460 1470 1480 1490 1500
LGGEFPVQDM KTGEGGLLQV TLEGINLKFM HSQVFIELSH IKKCNTVKGV
1510
FVLEEFGNYT IH
Length:1,512
Mass (Da):168,276
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42B99C96FF469C23
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTRUT00000041990; ENSTRUP00000041846; ENSTRUG00000016367

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTRUT00000041990; ENSTRUP00000041846; ENSTRUG00000016367

Phylogenomic databases

eggNOGiKOG3570 Eukaryota
ENOG410XP23 LUCA
GeneTreeiENSGT00940000156718

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13008 PTHR13008, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2UY17_TAKRU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2UY17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: December 5, 2018
Last modified: July 31, 2019
This is version 34 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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