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Protein

Putative hydroxypyruvate isomerase

Gene

hyi

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).UniRule annotation

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Proton donor/acceptorUniRule annotation1
Active sitei249Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomeraseUniRule annotation (EC:5.3.1.22UniRule annotation)
Gene namesi
Name:hyiImported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000026188

Structurei

3D structure databases

ProteinModelPortaliH2TND2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 218AP_endonuc_2InterPro annotationAdd BLAST193

Sequence similaritiesi

Belongs to the hyi family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4518 Eukaryota
COG3622 LUCA
GeneTreeiENSGT00390000005462
InParanoidiH2TND2
KOiK01816
OMAiCEYRPRA
OrthoDBiEOG091G0KZU
TreeFamiTF312858

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit

Sequencei

Sequence statusi: Complete.

H2TND2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLRFCANI SWLFTELPDF SKRIYAAAAA GFQAVEAAWL YDCDLSELQR
60 70 80 90 100
AREATGVEVV LINTPPGDVQ AGDLGLGAVP GREAEFRQGL DLALDYARSL
110 120 130 140 150
SCKRIHLMAG RVPVGSQRST VARDMENTFI QNLRYAADVL SKEGMTGLIE
160 170 180 190 200
PINSRITDPR YYLDSPHQAA AILEKVGRPN IKLQMDIFHC QIMDGNLSQN
210 220 230 240 250
LQKYLPIIAH IQIAQVPDRN EPDSAGELNY SFLFSTLEKH GYQGYIGCEY
260 270
KPLGSTKEGL GWLSKYTQQA TTTGVH
Length:276
Mass (Da):30,556
Last modified:March 21, 2012 - v1
Checksum:iDB3280FAD4A7355B
GO

Sequence databases

RefSeqiXP_003973855.1, XM_003973806.2

Genome annotation databases

EnsembliENSTRUT00000026295; ENSTRUP00000026188; ENSTRUG00000010400
GeneIDi101063307
KEGGitru:101063307

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_003973855.1, XM_003973806.2

3D structure databases

ProteinModelPortaliH2TND2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000026188

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000026295; ENSTRUP00000026188; ENSTRUG00000010400
GeneIDi101063307
KEGGitru:101063307

Organism-specific databases

CTDi81888

Phylogenomic databases

eggNOGiKOG4518 Eukaryota
COG3622 LUCA
GeneTreeiENSGT00390000005462
InParanoidiH2TND2
KOiK01816
OMAiCEYRPRA
OrthoDBiEOG091G0KZU
TreeFamiTF312858

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2TND2_TAKRU
AccessioniPrimary (citable) accession number: H2TND2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: March 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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