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Entry version 45 (12 Aug 2020)
Sequence version 3 (17 Jun 2020)
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Protein
Submitted name:

TUB like protein 4a

Gene
N/A
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TUB like protein 4aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31033 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
31033.ENSTRUP00000021739

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 218WD_REPEATS_REGIONInterPro annotationAdd BLAST127
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati92 – 123WDPROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni528 – 574DisorderedSequence analysisAdd BLAST47
Regioni769 – 804DisorderedSequence analysisAdd BLAST36
Regioni1078 – 1098DisorderedSequence analysisAdd BLAST21
Regioni1160 – 1180DisorderedSequence analysisAdd BLAST21
Regioni1481 – 1520DisorderedSequence analysisAdd BLAST40
Regioni1540 – 1629DisorderedSequence analysisAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili862 – 901Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi778 – 804PolarSequence analysisAdd BLAST27
Compositional biasi1499 – 1518Pro-richSequence analysisAdd BLAST20
Compositional biasi1559 – 1580PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1593 – 1612PolyampholyteSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2503, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002083_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2TAP9

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01167, Tub, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit
SSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H2TAP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SRTQTAEPGN RSAEMFAAVE HGPVICSDSN ILCLSWKGRV PKSEKEKPVC
60 70 80 90 100
RKRYYEEGWL ATGNSRGVVG VTFTSSHCRR DRPTPQRVNF NLRGHNSEVV
110 120 130 140 150
LVRWNEPFQK LATCDTDGGI FVWIQYEGRW SVELVNDRGA QVSDFTWSHD
160 170 180 190 200
GTQALISYRD GFVLVGSVSG QRHWSSEINL ESQITCGIWT PDDQQVLFGT
210 220 230 240 250
ADGQVIVMDC HGRMLAHILL HESDGIVSMS WNCPSFLVED SSESDMDSDD
260 270 280 290 300
YSQKPLLTVG FTSGDISLMN NYDDLSPTLI RTGLKDVVVQ WCSQGDLLAV
310 320 330 340 350
AGMERSLLPP DPSSPPPIRN ATVKFYNVRG EHIYSLDTPA QRPITTLCWG
360 370 380 390 400
HRDSRLFLAS GPALYILRVE HRVASLQLLC QQGIATAVKE EKDVAKLTMP
410 420 430 440 450
SRLGSYVTAA FVTTIKPPVP DPNNMRDFVS YPNAGNERLH CTMKRTEDNP
460 470 480 490 500
EVGSPCYTLY LEYMGGLVPI LKGRRISKLR PEFVIMDPKT DGKTDEIYGS
510 520 530 540 550
SLISAMIDSC NCSDSSDIEL SDDWVGKKSP KISRGSKSPK LPRINIDPRK
560 570 580 590 600
SPKLSRATQE ISRSPRLPIR KPSIGSPSLT RREFPLDDIT QQNYLAQVTS
610 620 630 640 650
NIWGTKFKIV GLATFLPANL GAVIYKTSLL HLQPRQMTIY LPEVRKISMD
660 670 680 690 700
CINLPVFSPN VFSEDEDDLP VTGPAGGADD NPPCTVNIPI APIHSPAQAM
710 720 730 740 750
SPAQNIGLVQ SLLANQNVQL DVLTNPATNP AGASAGPDQS QDAILTAQYT
760 770 780 790 800
VPTRYSSPGQ VIFGGLEIGR LMVGPPPSHH PSQQQQSAHH QQQHQQHHQQ
810 820 830 840 850
MQQLQQQQQQ MQQLQQQQQQ QQQMQQLQQQ QQQQQQMQQL QQQQLQQQQL
860 870 880 890 900
LQQQHLQQQL QQQHLQQQFQ HMQQQQQHLQ QQQMQQQQQQ QQQQQQQQQQ
910 920 930 940 950
QHSHQLQQLH IQIPVSSLPS GQTSGGAMHQ LQPGALQIQI PHPPADLVVE
960 970 980 990 1000
RALGGEHLLK IKNTRSTPQL AEADTVVFSA PLELSKMNPP PPYPGTVAAA
1010 1020 1030 1040 1050
VAAAAAATGG TPPPGEVCMK KGEFSLYPSG QQQAQYPTPL GYERITTFDS
1060 1070 1080 1090 1100
SGNVEEVCRP RTRLVCNQNV YALQGPGSSA TLRVTSSSSS TSSSSADKKI
1110 1120 1130 1140 1150
QLPYTSATLN RLTAPRYSIP IGDPPPYPDP ANQNSAVIRS SGQRLDSNLI
1160 1170 1180 1190 1200
HAALRRNSRE AALKVSQMSE PPRPLPPKAK NSNTLASSFH QRAPTALYTC
1210 1220 1230 1240 1250
SQCSSASSVA GSAPGSANGI AGGTIIRQDF PPGNGAPHST VIIHSNSGPP
1260 1270 1280 1290 1300
LPSQSTYNLL SSLEGSVAAP SSRERSDYVN SAFSEDESLN QSLRHLALGG
1310 1320 1330 1340 1350
SDASGLVVKR PPPYQWDPTA SDEVWVPQER TATLNLGPHK PPPLILSSSQ
1360 1370 1380 1390 1400
HLDVSRLPFV LSPKSPTSPN ATSLQASAAP TGYQVSLQYP STAAYSGVQL
1410 1420 1430 1440 1450
HPIQGSPHPC SPKEVVASVP FSQQDATIVL PQSYSANLAN LACCPLPPMY
1460 1470 1480 1490 1500
PGGSACAGLP IPPVTLHTPW GTYNSCPPKP PPPVPLPPKA SQLAAEKNVV
1510 1520 1530 1540 1550
SPPPPPPPPP PPPPAELPGH AGLQEAMAEA GEGFQEVLSL TESPVPQRSE
1560 1570 1580 1590 1600
KLSKKHRKRL DGRSDEPLAE GSKSKKEGRA MGDFNSLISS PRLGGRDKKK
1610 1620 1630 1640 1650
LKGQKEQQLK AKKINKAPAN SEFQDSSESE PELFISGDEL LNQCQSAKKG
1660 1670 1680 1690 1700
WKSKRNLRAA SELDEIRCRK SNEKEDRGLG NQGFVYVMAN KQPLWNEATQ
1710 1720 1730 1740 1750
VYQLDFGGRV TQESAKNFQI ELEGRQVMQF GRIDGNAYIL DFQYPFSAVQ
1760
AFAVALANVT QRLK
Length:1,764
Mass (Da):193,121
Last modified:June 17, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9873F5E3B14846E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A674N8H1A0A674N8H1_TAKRU
TUB like protein 4a
1,800Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A674P096A0A674P096_TAKRU
TUB like protein 4a
1,774Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTRUT00000021827; ENSTRUP00000021739; ENSTRUG00000008661

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000021739

Genome annotation databases

EnsembliENSTRUT00000021827; ENSTRUP00000021739; ENSTRUG00000008661

Phylogenomic databases

eggNOGiKOG2503, Eukaryota
GeneTreeiENSGT00940000155913
HOGENOMiCLU_002083_1_0_1
InParanoidiH2TAP9
TreeFamiTF314076

Family and domain databases

Gene3Di2.130.10.10, 2 hits
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167, Tub, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 2 hits
SUPFAMiSSF103657, SSF103657, 1 hit
SSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2TAP9_TAKRU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2TAP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: June 17, 2020
Last modified: August 12, 2020
This is version 45 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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