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Protein

Erythropoietin receptor

Gene

EPOR

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for erythropoietin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117Required for ligand bindingUniRule annotation1
Sitei426Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei456Required for STAT1/STAT3 activationUniRule annotation1
Sitei485Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin receptorUniRule annotation
Short name:
EPO-RUniRule annotation
Gene namesi
Name:EPORImported
ORF Names:CK820_G0026479Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:2388 EPOR

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei251 – 272HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501509336926 – 508Erythropoietin receptorSequence analysisAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 62UniRule annotation
Disulfide bondi91 ↔ 107UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiH2R6D1

Expressioni

Gene expression databases

BgeeiENSPTRG00000029123

Interactioni

Subunit structurei

Forms homodimers on EPO stimulation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei368Interaction with APS and STAT5, and activationUniRule annotation1
Sitei454Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000049007

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 247Fibronectin type-IIIInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00920000149107
InParanoidiH2R6D1
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

H2R6D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKAA LLAARGPEQL
60 70 80 90 100
LCFTERLEDL VCFWEEAASA GVGPGNYSFS YQLEDEPWKL CRLHQAPTAR
110 120 130 140 150
GAVRFWCSLP TADTSSFVPL ELRVTAASGA PRYHRVIHIN EVVLLDAPVG
160 170 180 190 200
LVARLADESG HVVLRWLPPP ETPMTSHIRY EVDVSAGNGA GSVQRVEILE
210 220 230 240 250
GRTECVLSNL RGRTRYTFAV RARMAEPSFG GFWSAWSEPV SLLTPSDLDP
260 270 280 290 300
LILTLSLILV LILVLLTVLA LLSHRRALKQ KIWPGIPSPE SEFEGLFTTH
310 320 330 340 350
KGNFQLWLYQ NDGCLWWSPC TPFTEDPPAS LEVLSERCWG TMQAVEPGTD
360 370 380 390 400
DEGPLLEPVG SEHAQDTYLV LDKWLLPQNP PSEDLPGPGG SVDIVAMDEG
410 420 430 440 450
SEASSCSSAL ASKPSPEGAS AASFEYTILD PSSQLLRPWT LCPELPPTPP
460 470 480 490 500
HLKYLYLVVS DSGISTDYSS GDSQGAQGGL SDGPYSNPYE NSLIPAAEPL

PPSYVACS
Length:508
Mass (Da):55,050
Last modified:February 28, 2018 - v2
Checksum:i01B37EAFDAF15A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04030688 Genomic DNA No translation available.
NBAG03000278 Genomic DNA Translation: PNI51406.1
RefSeqiXP_016790585.1, XM_016935096.1

Genome annotation databases

EnsembliENSPTRT00000019349; ENSPTRP00000049007; ENSPTRG00000029123
GeneIDi455728

Similar proteinsi

Entry informationi

Entry nameiH2R6D1_PANTR
AccessioniPrimary (citable) accession number: H2R6D1
Secondary accession number(s): A0A2J8LVU0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: June 20, 2018
This is version 36 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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