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Protein

3-hydroxyisobutyrate dehydrogenase

Gene

HIBADH

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.UniRule annotation

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NADUniRule annotation1
Binding sitei134NADUniRule annotation1
Active sitei209UniRule annotation1
Binding sitei284NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 68NADUniRule annotationAdd BLAST29
Nucleotide bindingi103 – 104NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processBranched-chain amino acid catabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00362

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyrate dehydrogenaseUniRule annotation (EC:1.1.1.31UniRule annotation)
Short name:
HIBADHUniRule annotation
Gene namesi
Name:HIBADHImported
Synonyms:LOC107966312Imported
ORF Names:CK820_G0034591Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:4386 HIBADH

Expressioni

Gene expression databases

BgeeiENSPTRG00000019024

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000048098

Structurei

3D structure databases

SMRiH2R5F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 200NAD_binding_2InterPro annotationAdd BLAST159
Domaini203 – 330NAD_binding_11InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0409 Eukaryota
COG2084 LUCA
GeneTreeiENSGT00530000063270
KOiK00020
OMAiWPSEVNN
OrthoDBiEOG091G0CUJ
TreeFamiTF314043

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR011548 HIBADH
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01692 HIBADH, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

H2R5F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLRLLGA ASGLRYWSRR LRPAAGSFAA VCSRSVASKT PVGFIGLGNM
60 70 80 90 100
GNPMAKNLMK HGYPLIIYDV FPDACKEFQD AGEQVVSSPA DVAEKADRII
110 120 130 140 150
TMLPTSINAI EAYSGANGIL KKVKKGSLLI DSSTIDPAVS KELAKEVEKM
160 170 180 190 200
GAVFMDAPVS GGVGAARSGN LTFMVGGVED EFAAAQELLG CMGSNVVYCG
210 220 230 240 250
AVGTGQAAKI CNNMLLAISM IGTAEAMNLG IRLGLDPKLL AKILNMSSGR
260 270 280 290 300
CWSSDTYNPV PGVMDGVPSA NNYQGGFGTT LMAKDLGLAQ DSATSTKSPI
310 320 330
LLGSLAHQIY RMMCAKGYSK KDFSSVFQFL REEETF
Length:336
Mass (Da):35,329
Last modified:March 21, 2012 - v1
Checksum:iDA3128774A91AF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160942 Genomic DNA No translation available.
AC163758 Genomic DNA No translation available.
AC195643 Genomic DNA No translation available.
GABC01002085 mRNA Translation: JAA09253.1
GABF01009263 mRNA Translation: JAA12882.1
GABD01009945 mRNA Translation: JAA23155.1
GABE01007358 mRNA Translation: JAA37381.1
NBAG03000325 Genomic DNA Translation: PNI40295.1
RefSeqiXP_016801048.1, XM_016945559.1
XP_519013.3, XM_519013.4

Genome annotation databases

EnsembliENSPTRT00000035166; ENSPTRP00000048098; ENSPTRG00000019024
ENSPTRT00000081749; ENSPTRP00000061962; ENSPTRG00000042926
GeneIDi463313
KEGGiptr:463313

Similar proteinsi

Entry informationi

Entry nameiH2R5F7_PANTR
AccessioniPrimary (citable) accession number: H2R5F7
Secondary accession number(s): A0A2J8KZ42
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 18, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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