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Protein
Submitted name:

5-hydroxytryptamine receptor 4

Gene

HTR4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine receptor 4Imported
Submitted name:
HTR4 isoform 4Imported
Gene namesi
Name:HTR4Imported
ORF Names:CK820_G0010041Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:13511 HTR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 45HelicalSequence analysisAdd BLAST26
Transmembranei57 – 79HelicalSequence analysisAdd BLAST23
Transmembranei99 – 117HelicalSequence analysisAdd BLAST19
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei192 – 213HelicalSequence analysisAdd BLAST22
Transmembranei260 – 281HelicalSequence analysisAdd BLAST22
Transmembranei293 – 315HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiH2R334

Expressioni

Gene expression databases

BgeeiENSPTRG00000017389 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000044834

Structurei

3D structure databases

ProteinModelPortaliH2R334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 312G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
InParanoidiH2R334
OMAiYRIYITA
OrthoDBiEOG091G06VI
TreeFamiTF316350

Family and domain databases

CDDicd15056 7tmA_5-HT4, 1 hit
InterProiView protein in InterPro
IPR001520 5HT4_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01059 5HT4RECEPTR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

H2R334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL
60 70 80 90 100
RKIKTNYFIV SLAFADLLVS VLVMPFGAIE LVQDIWIYGE MFCLVRTSLD
110 120 130 140 150
VLLTTASIFH LCCISLDRYY AICCQPLVYR NKMTPLRIAL MLGGCWVIPT
160 170 180 190 200
FISFLPIMQG WNNIGIIDLI EKRKFNQNSN STYCVFMVNK PYAITCSVVA
210 220 230 240 250
FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP QSADQHSTHR
260 270 280 290 300
MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL
310 320 330 340 350
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT
360
INGSTHVLRF
Length:360
Mass (Da):40,976
Last modified:February 28, 2018 - v2
Checksum:iF2B5D088F51F1121
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2J8NJA4A0A2J8NJA4_PANTR
5-hydroxytryptamine receptor 4
HTR4 CK820_G0010041
428Annotation score:
A0A2J8NJA7A0A2J8NJA7_PANTR
5-hydroxytryptamine receptor 4
HTR4 CK820_G0010041
388Annotation score:
A0A2I3T0F1A0A2I3T0F1_PANTR
5-hydroxytryptamine receptor 4
HTR4 CK820_G0010041
387Annotation score:
A0A2J8NJA8A0A2J8NJA8_PANTR
5-hydroxytryptamine receptor 4
HTR4 CK820_G0010041
378Annotation score:
A0A2I3SI45A0A2I3SI45_PANTR
5-hydroxytryptamine receptor 4
HTR4 CK820_G0010041
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04059121 Genomic DNA No translation available.
AACZ04059122 Genomic DNA No translation available.
AACZ04059123 Genomic DNA No translation available.
NBAG03000228 Genomic DNA Translation: PNI71848.1

Genome annotation databases

EnsembliENSPTRT00000046976; ENSPTRP00000044834; ENSPTRG00000017389

Similar proteinsi

Entry informationi

Entry nameiH2R334_PANTR
AccessioniPrimary (citable) accession number: H2R334
Secondary accession number(s): A0A2J8NJB5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: September 12, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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