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Protein
Submitted name:

ADGRG6 isoform 3

Gene

ADGRG6

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • laminin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ADGRG6 isoform 3Imported
Submitted name:
Adhesion G protein-coupled receptor G6Imported
Gene namesi
Name:ADGRG6Imported
ORF Names:CK820_G0000118Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:7885 ADGRG6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei866 – 889HelicalSequence analysisAdd BLAST24
Transmembranei901 – 922HelicalSequence analysisAdd BLAST22
Transmembranei928 – 950HelicalSequence analysisAdd BLAST23
Transmembranei970 – 991HelicalSequence analysisAdd BLAST22
Transmembranei1019 – 1049HelicalSequence analysisAdd BLAST31
Transmembranei1070 – 1089HelicalSequence analysisAdd BLAST20
Transmembranei1095 – 1117HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_501509325638 – 1250Sequence analysisAdd BLAST1213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiH2R1Q7

Expressioni

Gene expression databases

BgeeiENSPTRG00000018663 Expressed in 5 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000042713

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 149CUBInterPro annotationAdd BLAST109
Domaini800 – 852GPSInterPro annotationAdd BLAST53
Domaini864 – 1118G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
InParanoidiH2R1Q7
OrthoDBiEOG091G00P5
TreeFamiTF321769

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H2R1Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT
210 220 230 240 250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF
260 270 280 290 300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
310 320 330 340 350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA
360 370 380 390 400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN
410 420 430 440 450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV
460 470 480 490 500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK
510 520 530 540 550
LLKNNESLDE GLRLHTVNVR QLSHCLAMEE PKGYYWPSIQ PSEYVLPCLD
560 570 580 590 600
KPGFSASRTC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN
610 620 630 640 650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS
660 670 680 690 700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LGVSSLLPGT NAISNFSIGL
710 720 730 740 750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSQEDSVL VRRAQFTFFN
760 770 780 790 800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH
810 820 830 840 850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP
860 870 880 890 900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI
910 920 930 940 950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL
960 970 980 990 1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG
1010 1020 1030 1040 1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR
1060 1070 1080 1090 1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS
1110 1120 1130 1140 1150
IFNSLQGLFI FIFHCAMKEN VQKQWRRHLC CGRFRLADNS DWSKTATNII
1160 1170 1180 1190 1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNASMDKSL
1210 1220 1230 1240 1250
SKLAHADGDQ TSIIPVHQVI DKVKGYCNAH SDNFYKNIIM SDTFSHSTKF
Length:1,250
Mass (Da):139,991
Last modified:February 28, 2018 - v2
Checksum:i4FD62F472B686944
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3RWU7A0A2I3RWU7_PANTR
ADGRG6 isoform 1
ADGRG6 CK820_G0000118
1,221Annotation score:
A0A2I3SYT5A0A2I3SYT5_PANTR
ADGRG6 isoform 2
ADGRG6 CK820_G0000118
1,222Annotation score:
A0A2I3T5K2A0A2I3T5K2_PANTR
Adhesion G protein-coupled receptor...
ADGRG6
1,249Annotation score:
A0A2I3T275A0A2I3T275_PANTR
Adhesion G protein-coupled receptor...
ADGRG6
1,185Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04054463 Genomic DNA No translation available.
NBAG03000210 Genomic DNA Translation: PNI86948.1
RefSeqiXP_001172168.1, XM_001172168.4

Genome annotation databases

EnsembliENSPTRT00000049354; ENSPTRP00000042713; ENSPTRG00000018663
GeneIDi463034

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04054463 Genomic DNA No translation available.
NBAG03000210 Genomic DNA Translation: PNI86948.1
RefSeqiXP_001172168.1, XM_001172168.4

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000042713

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiH2R1Q7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000049354; ENSPTRP00000042713; ENSPTRG00000018663
GeneIDi463034

Organism-specific databases

CTDi57211
VGNCiVGNC:7885 ADGRG6

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
InParanoidiH2R1Q7
OrthoDBiEOG091G00P5
TreeFamiTF321769

Gene expression databases

BgeeiENSPTRG00000018663 Expressed in 5 organ(s), highest expression level in liver

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2R1Q7_PANTR
AccessioniPrimary (citable) accession number: H2R1Q7
Secondary accession number(s): A0A2J8PSF6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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