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Entry version 67 (07 Apr 2021)
Sequence version 2 (28 Feb 2018)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-bindingARBA annotation, S-adenosyl-L-methionineUniRule annotationARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002277 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:7657, KMT2A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H2R0N1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSPTRG00000004344, Expressed in cerebellum and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9598.ENSPTRP00000040970

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1084, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000208_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2R0N1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDSKMME

Database of Orthologous Groups

More...
OrthoDBi
738155at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319820

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H2R0N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS
110 120 130 140 150
SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGEDEQFLG
160 170 180 190 200
FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR SGSDRNSAIL SDPSVFSPLN
210 220 230 240 250
KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD ISELPKGNKE
260 270 280 290 300
DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV
310 320 330 340 350
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ
360 370 380 390 400
SPRRIKPVRI IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK
410 420 430 440 450
TQVKNIRQFI MPVVSAISSR IIKTPRRFIE DEDYDPPIKI ARLESTPNSR
460 470 480 490 500
FSAPSCGSSE KSSAASQHSS QMSSDSSRSS SPSVDTSTDS QASEEIQVLP
510 520 530 540 550
EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS RTTKKLSTLQ
560 570 580 590 600
SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS
610 620 630 640 650
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN
660 670 680 690 700
FRPPPLTPED VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP
710 720 730 740 750
RFTPSEAHSR IFESVTLPSN RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS
760 770 780 790 800
PSHSMRTRSG RLSTSELSPL TPPSSVSSSL SISVSPLATS ALNPTFTFPS
810 820 830 840 850
HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT PGSQTERGRN
860 870 880 890 900
KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ
910 920 930 940 950
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL
960 970 980 990 1000
GDTTAVKTKI LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK
1010 1020 1030 1040 1050
HSTSSIGSML AQADKLPMTD KRVASLLKKA KAQLCKIEKS KSLKQTDQPK
1060 1070 1080 1090 1100
AQGQESDSSE TSVRGPRIKH VCRRAAVALG RKRAVFPDDM PTLSALPWEE
1110 1120 1130 1140 1150
REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA PQEPPVKKGR
1160 1170 1180 1190 1200
RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM
1210 1220 1230 1240 1250
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKD SSVVKNVVDS SQKPTPSARE
1260 1270 1280 1290 1300
DPAPKKSSSE PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ
1310 1320 1330 1340 1350
PALVIPPQPP TTGPPRKEVP KTTPSEPKKK QPPPPESGPE QSKQKKVAPR
1360 1370 1380 1390 1400
PSIPVKQKPK EKEKPPPVNK QENAGTLNIL STLSNGNSSK QKIPADGVHR
1410 1420 1430 1440 1450
IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS GHVEFVYCQV
1460 1470 1480 1490 1500
CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK
1510 1520 1530 1540 1550
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS
1560 1570 1580 1590 1600
HDFSLCHDCA KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE
1610 1620 1630 1640 1650
NLSGTEDEMY EILSNLPESV AYTCVNCTER HPAEWRLALE KELQISLKQV
1660 1670 1680 1690 1700
LTALLNSRTT SHLLRYRQAA KPPDLNPETE ESIPSRSSPE GPDPPVLTEV
1710 1720 1730 1740 1750
SKQDDQQPLD LEGVKRKMDQ GNYTSVLEFS DDIVKIIQAA INSDGGQPEI
1760 1770 1780 1790 1800
KKANSMVKSF FIRQMERVFP WFSVKKSRFW EPNKVSSNSG MLPNAVLPPS
1810 1820 1830 1840 1850
LDHNYAQWQE REENSHTEQP PLMKKIIPAP KPKGPGEPDS PTPLHPPTPP
1860 1870 1880 1890 1900
ILSTDRSRED SPELNPPPGI EDNRQCALCL TYGDDSANDA GRLLYIGQNE
1910 1920 1930 1940 1950
WTHVNCALWS AEVFEDDDGS LKNVHMAVIR GKQLRCEFCQ KPGATVGCCL
1960 1970 1980 1990 2000
TSCTSNYHFM CSRAKNCVFL DDKKVYCQRH RDLIKGEVVP ENGFEVFRRV
2010 2020 2030 2040 2050
FVDFEGISLR RKFLNGLEPE NIHMMIGSMT IDCLGILNDL SDCEDKLFPI
2060 2070 2080 2090 2100
GYQCSRVYWS TTDARKRCVY TCKIVECRPP VVEPDINSTV EHDENRTIAH
2110 2120 2130 2140 2150
SPTSFTESSS KESQNTAEII SPPSPDRPPH SQTSGSCYYH VISKVPRIRT
2160 2170 2180 2190 2200
PSYSPTQRSP GCRPLPSAGS PTPTTHEIVT VGDPLLSSGL RSIGSRRHST
2210 2220 2230 2240 2250
SSLSPQRSKL RIMSPMRTGN TYSRNNVSSV STIGTATDLE SSAKVVDHVL
2260 2270 2280 2290 2300
GPLNSSTSLG QNTSTSSNLQ RTVVTVGNKN SHLDGSSSSE MKQSSASDLA
2310 2320 2330 2340 2350
SKSSSLKGEK TKVLSSKSSE GSAHNVAYPG IPKLAPQVHN TTSRELNVSK
2360 2370 2380 2390 2400
IGSFAEPSSV SFSSKEALSF PHLHLRGQRN DRDQHTDSTQ SANSSADEDT
2410 2420 2430 2440 2450
EVKTLKLSGM SNRSSIINEH MGSSSRDRRQ KGKKSCKETF KEKHSSKSFL
2460 2470 2480 2490 2500
EPGQVTTGEE GNLKPEFMDE VLTPEYMGQR PCNNVSSDKI GDKGLSMPGV
2510 2520 2530 2540 2550
PKAPPMQVEG SAKELQAPRK RTVKVTLTPL KMENESQSKN ALKESSPASP
2560 2570 2580 2590 2600
LQIESTSPTE PISASENPGD GPVAQPSPNN TSCQDSQSNN YQNLPVQDRN
2610 2620 2630 2640 2650
LMLPDGPKPQ EDGSFKRRYP RRSARARSNM FFGLTPLYGV RSYGEEDIPF
2660 2670 2680 2690 2700
YSSSTGKKRG KRSAEGQVDG ADDLSTSDED DLYYYNFTRT VISSGGEERL
2710 2720 2730 2740 2750
ASHNLFREEE QCDLPKISQL DGVDDGTESD TSVTATTRKS SQIPKRNGKE
2760 2770 2780 2790 2800
NGTENLKIDR PEDAGEKDHV TKSSVGHKNE PKMDNCHSVS RVKTQGQDSL
2810 2820 2830 2840 2850
EAQLSSLESS RRVHTSTPSD KNLLDTYNTE LLKSDSDNNN SDDCGNILPS
2860 2870 2880 2890 2900
DIMDFVLKNT PSMQALGESP ESSSSELLNL GEGLGLDSNR EKDMGLFEVF
2910 2920 2930 2940 2950
SQQLPTTEPV DSSVSSSISA EEQFELPLEL PSDLSVLTTR SPTVPSQNPS
2960 2970 2980 2990 3000
RLAVISDSGE KRVTITEKSV ASSEGDPALL SPGVDPTPEG HMTPDHFIQG
3010 3020 3030 3040 3050
HMDADHISSP PCGSVEQGHG NNQDLTRNSS TPGLQVPVSP TVPIQNQKYV
3060 3070 3080 3090 3100
PNSTDSPGPS QISNAAVQTT PPHLKPATEK LIVVNQNMQP LYVLQTLPNG
3110 3120 3130 3140 3150
VTQKIQLTSS VSSTPSVMET NTSVLGPMGG GLTLTTGLNP SLPTSQSLFP
3160 3170 3180 3190 3200
SASKGLLPMS HHQHLHSFPA ATQSSFPPNI SNPPSGLLIG VQPPPDPQLL
3210 3220 3230 3240 3250
VSESSQRTDL STTVATPSSG LKKRPISRLQ TRKNKKLAPS STPSNIAPSD
3260 3270 3280 3290 3300
VVSNMTLINF TPSQLPNHPS LLDLGSLNTS SHRTVPNIIK RSKSSIMYFE
3310 3320 3330 3340 3350
PAPLLPQSVG GTAATAAGTS TISQDTSHLT SGSVSGLASS SSVLNVVSMQ
3360 3370 3380 3390 3400
TTTTPTSSAS VPGHVTLTNP RLLGTPDIGS ISNLLIKASQ QSLGIQDQPV
3410 3420 3430 3440 3450
ALPPSSGMFP QLGTSQTPST AAMTAASSIC VLPSTQTTGI TAASPSGEAD
3460 3470 3480 3490 3500
EHYQLQHVNQ LLASKTGIHS SQRDLDSASG PQVSNFTQTV DAPNSMGLEQ
3510 3520 3530 3540 3550
NKALSSAVQA SPTSPGGSPS SPSSGQRSAS PSVPGPTKPK PKTKRFQLPL
3560 3570 3580 3590 3600
DKGNGKKHKV SHLRTSSSEA HIPDQETTSL TSGTGTPGAE AEQQDTASVE
3610 3620 3630 3640 3650
QSSQKECGQP AGQVAVLPEV QVTQNPANEQ ESTEPKTVEE EESNFSSPLM
3660 3670 3680 3690 3700
LWLQQEQKRK ESITEKKPKK GLVFEISSDD GFQICAESIE DAWKSLTDKV
3710 3720 3730 3740 3750
QEARSNARLK QLSFAGVNGL RMLGILHDAV VFLIEQLSGA KHCRNYKFRF
3760 3770 3780 3790 3800
HKPEEANEPP LNPHGSARAE VHLRKSAFDM FNFLASKHRQ PPEYNPNDEE
3810 3820 3830 3840 3850
EEEVQLKSAR RATSMDLPMP MRFRHLKKTS KEAVGVYRSP IHGRGLFCKR
3860 3870 3880 3890 3900
NIDAGEMVIE YAGNVIRSIQ TDKREKYYDS KGIGCYMFRI DDSEVVDATM
3910 3920 3930 3940 3950
HGNAARFINH SCEPNCYSRV INIDGQKHIV IFAMRKIYRG EELTYDYKFP
3960 3970
IEDASNKLPC NCGAKKCRKF LN
Length:3,972
Mass (Da):432,014
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC72697ED91EF287
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3SPK2A0A2I3SPK2_PANTR
Histone-lysine N-methyltransferase
KMT2A
3,983Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACZ04006748 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009422533.1, XM_009424258.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPTRT00000044431; ENSPTRP00000040970; ENSPTRG00000004344

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
451587

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04006748 Genomic DNA No translation available.
RefSeqiXP_009422533.1, XM_009424258.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000040970

Proteomic databases

PaxDbiH2R0N1

Genome annotation databases

EnsembliENSPTRT00000044431; ENSPTRP00000040970; ENSPTRG00000004344
GeneIDi451587

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4297
VGNCiVGNC:7657, KMT2A

Phylogenomic databases

eggNOGiKOG1084, Eukaryota
GeneTreeiENSGT00940000160099
HOGENOMiCLU_000208_2_0_1
InParanoidiH2R0N1
OMAiYDSKMME
OrthoDBi738155at2759
TreeFamiTF319820

Gene expression databases

BgeeiENSPTRG00000004344, Expressed in cerebellum and 7 other tissues

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2R0N1_PANTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2R0N1
Secondary accession number(s): A0A2J8N2M3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: April 7, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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