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Protein
Submitted name:

NOTCH1 isoform 1

Gene

NOTCH1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi432Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi435Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi452Calcium 2UniRule annotation1
Metal bindingi453Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi455Calcium 2UniRule annotation1
Metal bindingi469Calcium 2UniRule annotation1
Metal bindingi470Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi490Calcium 3UniRule annotation1
Metal bindingi491Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi493Calcium 3UniRule annotation1
Metal bindingi507Calcium 3UniRule annotation1
Metal bindingi508Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NOTCH1 isoform 1Imported
Submitted name:
Notch 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH1Imported
ORF Names:CK820_G0012017Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002277 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:4807 NOTCH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509319319 – 2555Sequence analysisAdd BLAST2537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 57PROSITE-ProRule annotation
Disulfide bondi89 ↔ 98PROSITE-ProRule annotation
Disulfide bondi129 ↔ 138PROSITE-ProRule annotation
Disulfide bondi166 ↔ 175PROSITE-ProRule annotation
Disulfide bondi206 ↔ 215PROSITE-ProRule annotation
Disulfide bondi245 ↔ 254PROSITE-ProRule annotation
Disulfide bondi283 ↔ 292PROSITE-ProRule annotation
Disulfide bondi323 ↔ 332PROSITE-ProRule annotation
Disulfide bondi361 ↔ 370PROSITE-ProRule annotation
Disulfide bondi381 ↔ 398PROSITE-ProRule annotation
Disulfide bondi400 ↔ 409PROSITE-ProRule annotation
Disulfide bondi416 ↔ 429UniRule annotation
Disulfide bondi423 ↔ 438UniRule annotation
Disulfide bondi440 ↔ 449UniRule annotation
Disulfide bondi456 ↔ 467UniRule annotation
Disulfide bondi461 ↔ 476UniRule annotation
Disulfide bondi478 ↔ 487UniRule annotation
Disulfide bondi494 ↔ 505UniRule annotation
Disulfide bondi499 ↔ 514UniRule annotation
Disulfide bondi516 ↔ 525UniRule annotation
Disulfide bondi554 ↔ 563PROSITE-ProRule annotation
Disulfide bondi570 ↔ 580PROSITE-ProRule annotation
Disulfide bondi591 ↔ 600PROSITE-ProRule annotation
Disulfide bondi629 ↔ 638PROSITE-ProRule annotation
Disulfide bondi645 ↔ 655PROSITE-ProRule annotation
Disulfide bondi666 ↔ 675PROSITE-ProRule annotation
Disulfide bondi704 ↔ 713PROSITE-ProRule annotation
Disulfide bondi720 ↔ 730PROSITE-ProRule annotation
Disulfide bondi741 ↔ 750PROSITE-ProRule annotation
Disulfide bondi779 ↔ 788PROSITE-ProRule annotation
Disulfide bondi817 ↔ 826PROSITE-ProRule annotation
Disulfide bondi838 ↔ 855PROSITE-ProRule annotation
Disulfide bondi857 ↔ 866PROSITE-ProRule annotation
Disulfide bondi895 ↔ 904PROSITE-ProRule annotation
Disulfide bondi933 ↔ 942PROSITE-ProRule annotation
Disulfide bondi971 ↔ 980PROSITE-ProRule annotation
Disulfide bondi1009 ↔ 1018PROSITE-ProRule annotation
Disulfide bondi1047 ↔ 1056PROSITE-ProRule annotation
Disulfide bondi1085 ↔ 1094PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1122PROSITE-ProRule annotation
Disulfide bondi1133 ↔ 1142PROSITE-ProRule annotation
Disulfide bondi1171 ↔ 1180PROSITE-ProRule annotation
Disulfide bondi1209 ↔ 1218PROSITE-ProRule annotation
Disulfide bondi1255 ↔ 1264PROSITE-ProRule annotation
Disulfide bondi1276 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1295 ↔ 1304PROSITE-ProRule annotation
Disulfide bondi1336 ↔ 1345PROSITE-ProRule annotation
Disulfide bondi1374 ↔ 1383PROSITE-ProRule annotation
Disulfide bondi1397 ↔ 1414PROSITE-ProRule annotation
Disulfide bondi1416 ↔ 1425PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H2QY65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSPTRG00000021561 Expressed in 6 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9598.ENSPTRP00000036924

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 58EGF-likeInterPro annotationAdd BLAST39
Domaini59 – 99EGF-likeInterPro annotationAdd BLAST41
Domaini102 – 139EGF-likeInterPro annotationAdd BLAST38
Domaini140 – 176EGF-likeInterPro annotationAdd BLAST37
Domaini178 – 216EGF-likeInterPro annotationAdd BLAST39
Domaini218 – 255EGF-likeInterPro annotationAdd BLAST38
Domaini257 – 293EGF-likeInterPro annotationAdd BLAST37
Domaini295 – 333EGF-likeInterPro annotationAdd BLAST39
Domaini335 – 371EGF-likeInterPro annotationAdd BLAST37
Domaini372 – 410EGF-likeInterPro annotationAdd BLAST39
Domaini412 – 450EGF-likeInterPro annotationAdd BLAST39
Domaini452 – 488EGF-likeInterPro annotationAdd BLAST37
Domaini490 – 526EGF-likeInterPro annotationAdd BLAST37
Domaini528 – 564EGF-likeInterPro annotationAdd BLAST37
Domaini566 – 601EGF-likeInterPro annotationAdd BLAST36
Domaini603 – 639EGF-likeInterPro annotationAdd BLAST37
Domaini641 – 676EGF-likeInterPro annotationAdd BLAST36
Domaini678 – 714EGF-likeInterPro annotationAdd BLAST37
Domaini716 – 751EGF-likeInterPro annotationAdd BLAST36
Domaini753 – 789EGF-likeInterPro annotationAdd BLAST37
Domaini791 – 827EGF-likeInterPro annotationAdd BLAST37
Domaini829 – 867EGF-likeInterPro annotationAdd BLAST39
Domaini869 – 905EGF-likeInterPro annotationAdd BLAST37
Domaini907 – 943EGF-likeInterPro annotationAdd BLAST37
Domaini945 – 981EGF-likeInterPro annotationAdd BLAST37
Domaini983 – 1019EGF-likeInterPro annotationAdd BLAST37
Domaini1021 – 1057EGF-likeInterPro annotationAdd BLAST37
Domaini1059 – 1095EGF-likeInterPro annotationAdd BLAST37
Domaini1108 – 1143EGF-likeInterPro annotationAdd BLAST36
Domaini1145 – 1181EGF-likeInterPro annotationAdd BLAST37
Domaini1183 – 1219EGF-likeInterPro annotationAdd BLAST37
Domaini1228 – 1265EGF-likeInterPro annotationAdd BLAST38
Domaini1267 – 1305EGF-likeInterPro annotationAdd BLAST39
Domaini1307 – 1346EGF-likeInterPro annotationAdd BLAST40
Domaini1348 – 1384EGF-likeInterPro annotationAdd BLAST37
Domaini1387 – 1426EGF-likeInterPro annotationAdd BLAST40
Domaini1449 – 1489LNRInterPro annotationAdd BLAST41
Domaini1490 – 1531LNRInterPro annotationAdd BLAST42
Domaini1532 – 1571LNRInterPro annotationAdd BLAST40
Domaini1873 – 2113ANK_REP_REGIONInterPro annotationAdd BLAST241
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1927 – 1959ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1994 – 2026ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2027 – 2059ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2060 – 2092ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157157

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2QY65

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRDCESK

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351641

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01984 NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 8 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H2QY65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPLLAPLLC LALLPALAAR GPRCSQPGET CLNGGKCEAA NGTEACVCGG
60 70 80 90 100
AFVGPRCQDP NPCLSTPCKN AGTCHVVDRR GVADYACSCP LGFSGPLCLT
110 120 130 140 150
PLDNACLTNP CRNGGTCDLL TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA
160 170 180 190 200
NGGQCLPFEA SYICHCPPSF HGPTCRQDVN ECGQKPGLCR HGGTCHNEVG
210 220 230 240 250
SYRCVCRATH TGPNCERPYV PCSPSPCQNG GTCRPTGDVT HECACLPGFT
260 270 280 290 300
GQNCEENIDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ
310 320 330 340 350
LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFHGATC
360 370 380 390 400
HDRVASFYCE CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC
410 420 430 440 450
PSGYTGPACS QDVDECSLGA NPCEHAGKCI NTLGSFECQC LQGYTGPRCE
460 470 480 490 500
IDVNECVSNP CQNDATCLDQ IGEFQCICMP GYEGVHCEVN TDECASSPCL
510 520 530 540 550
HNGRCLDKIN EFQCECPTGF TGHLCQYDVD ECASTPCKNG AKCLDGPNTY
560 570 580 590 600
TCVCTEGYTG THCEVDIDEC DPDPCHYGSC KDGVATFTCL CRPGYTGHHC
610 620 630 640 650
ETNINECSSQ PCRHGGTCQD RDNAYLCFCL KGTTGPNCEI NLDDCASSPC
660 670 680 690 700
DSGTCLDKID GYECACEPGY TGSMCNINID ECVGNPCHNG GTCEDGINGF
710 720 730 740 750
TCRCPEGYHD PTCLSEVNEC NSNPCVHGAC RDSLNGYKCD CDPGWSGTNC
760 770 780 790 800
DINNNECESN PCVNGGTCKD MTSGYVCTCR EGFSGPNCQT NINECASNPC
810 820 830 840 850
LNQGTCIDDV AGYKCNCLLP YTGDTCEVVL APCAPSPCRN GGECRQSEDY
860 870 880 890 900
ESFSCVCPTG WQGQTCEVDI NECVLSPCRH GASCQNTHGG YRCHCQAGYS
910 920 930 940 950
GRNCETDIDD CRPNPCHNGG SCTDGINTAF CECLPGFRGT FCEEDINECA
960 970 980 990 1000
SDPCRNGANC TDCVDSYTCT CPAGFSGIHC ENNTPDCTES SCFNGGTCVD
1010 1020 1030 1040 1050
GINSFTCLCP PGFTGSYCQH DVNECDSQPC LHGGTCQDGC GSYRCTCPQG
1060 1070 1080 1090 1100
YTGPNCQNLV HWCDSSPCKN GGKCWQTHTQ YRCECPSGWT GLYCDVPSVS
1110 1120 1130 1140 1150
CEVAAQRQGV DVARLCQHGG LCVDAGNTHH CRCQAGYTGS YCEDLVDECS
1160 1170 1180 1190 1200
PSPCQNGATC TDYLGGYSCK CVAGYHGVNC SEEIDECLSH PCQNGGTCLD
1210 1220 1230 1240 1250
LPNTYKCSCP RGTQGVHCEI NVDDCNPPVD PVSRSPKCFN NGTCVDQVGG
1260 1270 1280 1290 1300
YSCTCPPGFV GERCEGDVNE CLSNPCDARG TQNCVQRVND FHCECRAGHT
1310 1320 1330 1340 1350
GRRCESVING CKGKPCKNGG TCAVASNTAR GFICKCPAGF EGATCENDAR
1360 1370 1380 1390 1400
TCGSLRCLNG GTCISGPRSP TCLCLGPFTG PECQFPASSP CLGGNPCYNQ
1410 1420 1430 1440 1450
GTCEPTSESP FYRCLCPAKF NGLLCHILDY SFGGGAGRDI PPPLIEEACE
1460 1470 1480 1490 1500
LPECQEDAGN KVCSLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF
1510 1520 1530 1540 1550
SDGHCDSQCN SAGCLFDGFD CQRAEGQCNP LYDQYCKDHF SDGHCDQGCN
1560 1570 1580 1590 1600
SAECEWDGLD CAEHVPERLA AGTLVVVVLM PPEQLRNSSF HFLRELSRVL
1610 1620 1630 1640 1650
HTNVVFKRDA HGQQMIFPYY GREEELRKHP IKRAAEGWAA PDALLGQVKA
1660 1670 1680 1690 1700
SLLPGGSEGG RRRRELDPMD VRGSIVYLEI DNRQCVQASS QCFQSATDVA
1710 1720 1730 1740 1750
AFLGALASLG SLNIPYKIEA VQSETVEPPP PAQLHFMYVA AAAFVLLFFV
1760 1770 1780 1790 1800
GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA
1810 1820 1830 1840 1850
SDGALMDDNQ NEWGDEDLET KKFRFEEPVV LPDLDDQTDH RQWTQQHLDA
1860 1870 1880 1890 1900
ADLRMSAMAP TPPQGEVDAD CMDVNVRGPD GFTPLMIASC SGGGLETGNS
1910 1920 1930 1940 1950
EEEEDAPAVI SDFIYQGASL HNQTDRTGET ALHLAARYSR SDAAKRLLEA
1960 1970 1980 1990 2000
SADANIQDNM GRTPLHAAVS ADAQGVFQIL IRNRATDLDA RMHDGTTPLI
2010 2020 2030 2040 2050
LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN VDAAVVLLKN
2060 2070 2080 2090 2100
GANKDMQNNR EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI
2110 2120 2130 2140 2150
AQERMHHDIV RLLDEYNLVR SPQLHGAPLG GTPTLSPPLC SPNGYLGSLK
2160 2170 2180 2190 2200
PGVQGKKVRK PSSKGLACGS KEAKDLKARR KKSQDGKGCL LDSSGMLSPV
2210 2220 2230 2240 2250
DSLESPHGYL SDVASPPLLP SPFQQSPSVP LNHLPGMPDT HLGIGHLNVV
2260 2270 2280 2290 2300
AKPEMAALGG GGRLAFETGP PRLSHLPVAS GTSTVLGSNS GGALNFTVGG
2310 2320 2330 2340 2350
STSLNGQCEW LSRLQSGMVP NQYNPLRGSV APGPLSTQAP SLQHGMVGPL
2360 2370 2380 2390 2400
HSSLAASALS QMMSYQGLPS TRLATQPHLV QTQQVQPQNL QMQQQNLQPA
2410 2420 2430 2440 2450
NIQQQQSLQP PPPPPQPHLG VSSAASGHLG RSFLSGEPSQ ADVQPLGPSS
2460 2470 2480 2490 2500
LAVHTILPQE SPALPTSLPS SLVPPVTAAQ FLTPPSQHSY SSPVDNTPSH
2510 2520 2530 2540 2550
QLQVPEHPFL TPSPESPDQW SSSSPHSNVS DWSEGVSSPP TSMQSQIARI

PEAFK
Length:2,555
Mass (Da):272,672
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC3E0ADF9B169D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3T0D0A0A2I3T0D0_PANTR
Notch 1
NOTCH1
2,526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3S400A0A2I3S400_PANTR
Notch 1
NOTCH1
2,523Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AACZ04057934 Genomic DNA No translation available.
NBAG03000232 Genomic DNA Translation: PNI68543.1

NCBI Reference Sequences

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RefSeqi
XP_520371.3, XM_520371.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSPTRT00000039960; ENSPTRP00000036924; ENSPTRG00000021561

Database of genes from NCBI RefSeq genomes

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GeneIDi
464865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04057934 Genomic DNA No translation available.
NBAG03000232 Genomic DNA Translation: PNI68543.1
RefSeqiXP_520371.3, XM_520371.5

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000036924

Proteomic databases

PaxDbiH2QY65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000039960; ENSPTRP00000036924; ENSPTRG00000021561
GeneIDi464865

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4851
VGNCiVGNC:4807 NOTCH1

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000157157
InParanoidiH2QY65
OMAiGRDCESK
OrthoDBi7525at2759
TreeFamiTF351641

Gene expression databases

BgeeiENSPTRG00000021561 Expressed in 6 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 25 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 6 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 35 hits
PS01186 EGF_2, 27 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 8 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2QY65_PANTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2QY65
Secondary accession number(s): A0A2J8N9T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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