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Protein

mRNA-capping enzyme

Gene

RNGTT

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.UniRule annotation

Catalytic activityi

A 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.UniRule annotation
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126For RNA 5'-triphosphatase activityUniRule annotation1
Active sitei294N6-GMP-lysine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, NucleotidyltransferaseUniRule annotationImported, Transferase
Biological processmRNA cappingUniRule annotation, mRNA processing
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-capping enzymeUniRule annotation
Including the following 2 domains:
Polynucleotide 5'-triphosphataseUniRule annotation (EC:3.1.3.33UniRule annotation)
mRNA guanylyltransferaseUniRule annotation (EC:2.7.7.50UniRule annotation)
Alternative name(s):
GTP--RNA guanylyltransferaseUniRule annotation
Short name:
GTaseUniRule annotation
Gene namesi
Name:RNGTTImported
ORF Names:CK820_G0000777Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:3686 RNGTT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000018413 Expressed in 6 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000031457

Structurei

3D structure databases

SMRiH2QTD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 171TYR_PHOSPHATASE_2InterPro annotationAdd BLAST68

Sequence similaritiesi

In the C-terminal section; belongs to the eukaryotic GTase family.UniRule annotation
In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00530000063473
OMAiPELPEWC
OrthoDBiEOG091G063D
TreeFamiTF314914

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR017074 mRNA_cap_enz_bifunc
IPR001339 mRNA_cap_enzyme
IPR013846 mRNA_cap_enzyme_C
IPR012340 NA-bd_OB-fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF03919 mRNA_cap_C, 1 hit
PF01331 mRNA_cap_enzyme, 1 hit
PIRSFiPIRSF036958 mRNA_capping_HCE, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H2QTD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHNKIPPRW LNCPRRGQPV AGRFLPLKTM LGPRYDSQVA EENRFHPSML
60 70 80 90 100
SNYLKSLKVK MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT
110 120 130 140 150
ENTETFIRLC ERFNERNPPE LIGVHCTHGF NRTGFLICAF LVEKMDWSIE
160 170 180 190 200
AAVATFAQAR PPGIYKGDYL KELFRRYGDI EEAPPPPLLP DWCFEDDEDE
210 220 230 240 250
DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG VTQVTTQPKL
260 270 280 290 300
GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY
310 320 330 340 350
MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR
360 370 380 390 400
VNGQAVPRYL IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL
410 420 430 440 450
IDKTQEPFSV RNKPFFDICT SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP
460 470 480 490 500
GRCDDILKWK PPSLNSVDFR LKITRMGGEG LLPQNVGLLY VGGYERPFAQ
510 520 530 540 550
IKVTKELKQY DNKIIECKFE NNSWVFMRQR TDKSFPNAYN TAMAVCNSIS
560 570 580 590
NPVTKEMLFE FIDRCTAASQ GQKRKHHLDP DTELMPPPPP KRPRPLT
Length:597
Mass (Da):68,557
Last modified:March 21, 2012 - v1
Checksum:i51CEEC1B190603DE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3RR87A0A2I3RR87_PANTR
mRNA-capping enzyme
RNGTT CK820_G0000777
574Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04069768 Genomic DNA No translation available.
AACZ04069769 Genomic DNA No translation available.
AACZ04069770 Genomic DNA No translation available.
GABC01005094 mRNA Translation: JAA06244.1
GABF01009398 mRNA Translation: JAA12747.1
GABD01002081 mRNA Translation: JAA31019.1
GABE01001925 mRNA Translation: JAA42814.1
GABE01001924 mRNA Translation: JAA42815.1
NBAG03000210 Genomic DNA Translation: PNI87948.1
RefSeqiXP_518633.3, XM_518633.5

Genome annotation databases

EnsembliENSPTRT00000034037; ENSPTRP00000031457; ENSPTRG00000018413
GeneIDi462878

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04069768 Genomic DNA No translation available.
AACZ04069769 Genomic DNA No translation available.
AACZ04069770 Genomic DNA No translation available.
GABC01005094 mRNA Translation: JAA06244.1
GABF01009398 mRNA Translation: JAA12747.1
GABD01002081 mRNA Translation: JAA31019.1
GABE01001925 mRNA Translation: JAA42814.1
GABE01001924 mRNA Translation: JAA42815.1
NBAG03000210 Genomic DNA Translation: PNI87948.1
RefSeqiXP_518633.3, XM_518633.5

3D structure databases

SMRiH2QTD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000031457

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000034037; ENSPTRP00000031457; ENSPTRG00000018413
GeneIDi462878

Organism-specific databases

CTDi8732
VGNCiVGNC:3686 RNGTT

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00530000063473
OMAiPELPEWC
OrthoDBiEOG091G063D
TreeFamiTF314914

Gene expression databases

BgeeiENSPTRG00000018413 Expressed in 6 organ(s), highest expression level in testis

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR017074 mRNA_cap_enz_bifunc
IPR001339 mRNA_cap_enzyme
IPR013846 mRNA_cap_enzyme_C
IPR012340 NA-bd_OB-fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF03919 mRNA_cap_C, 1 hit
PF01331 mRNA_cap_enzyme, 1 hit
PIRSFiPIRSF036958 mRNA_capping_HCE, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2QTD9_PANTR
AccessioniPrimary (citable) accession number: H2QTD9
Secondary accession number(s): A0A2J8PVA6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 7, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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