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Protein

Toll-like receptor

Gene

TLR2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotationSAAS annotation
Biological processImmunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:TLR2Imported
ORF Names:CK820_G0016969Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:12860 TLR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei589 – 612HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501501980321 – 784Toll-like receptorUniRule annotationAdd BLAST764

Expressioni

Gene expression databases

BgeeiENSPTRG00000016528 Expressed in 5 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH2QQA8
SMRiH2QQA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini639 – 784TIRInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
OMAiIPQRFCK
OrthoDBiEOG091G05L8
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027185 TLR2
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF17 PTHR24365:SF17, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01463 LRRCT, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits
PS50104 TIR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

H2QQA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL
60 70 80 90 100
TEAVKSLDLS NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG
110 120 130 140 150
SLEHLDLSYN YLSNLSSSWF KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK
160 170 180 190 200
LQILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE SKSLKSIQNV
210 220 230 240 250
SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFRFS ELSTGETNSL
260 270 280 290 300
IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN
310 320 330 340 350
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL
360 370 380 390 400
VPCLLSQHLK SLEYLDLSEN LIVEEYLKNS ACEDAWPSLQ TLILRQNHLA
410 420 430 440 450
SLEKTGETLL TLKNLTNVDI SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS
460 470 480 490 500
VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM
510 520 530 540 550
LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA
560 570 580 590 600
LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL
610 620 630 640 650
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER
660 670 680 690 700
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILILLEPI EKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA AIKS
Length:784
Mass (Da):89,815
Last modified:March 21, 2012 - v1
Checksum:i8BD5E5B903B1083F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3Y613TLR2_PANTR
Toll-like receptor 2
TLR2
784Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04005062 Genomic DNA No translation available.
NBAG03000243 Genomic DNA Translation: PNI63246.1
RefSeqiXP_009446590.1, XM_009448315.2
XP_009446592.1, XM_009448317.2
XP_009446594.1, XM_009448319.2
XP_016806508.1, XM_016951019.1
UniGeneiPtr.3835

Genome annotation databases

EnsembliENSPTRT00000030727; ENSPTRP00000028379; ENSPTRG00000016528
GeneIDi471325

Similar proteinsi

Entry informationi

Entry nameiH2QQA8_PANTR
AccessioniPrimary (citable) accession number: H2QQA8
Secondary accession number(s): A0A2J8MUP8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 12, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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