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Protein
Submitted name:

Laminin subunit beta 2

Gene

LAMB2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit beta 2Imported
Gene namesi
Name:LAMB2Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:6355 LAMB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_501411600933 – 1798Sequence analysisAdd BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi377 ↔ 386PROSITE-ProRule annotation
Disulfide bondi440 ↔ 449PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
Disulfide bondi522 ↔ 534PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi783 ↔ 795PROSITE-ProRule annotation
Disulfide bondi785 ↔ 802PROSITE-ProRule annotation
Disulfide bondi804 ↔ 813PROSITE-ProRule annotation
Disulfide bondi831 ↔ 843PROSITE-ProRule annotation
Disulfide bondi833 ↔ 850PROSITE-ProRule annotation
Disulfide bondi852 ↔ 861PROSITE-ProRule annotation
Disulfide bondi896 ↔ 905PROSITE-ProRule annotation
Disulfide bondi956 ↔ 965PROSITE-ProRule annotation
Disulfide bondi1010 ↔ 1019PROSITE-ProRule annotation
Disulfide bondi1067 ↔ 1076PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1155PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiH2QMK9

Expressioni

Gene expression databases

BgeeiENSPTRG00000014912

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025746

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 282Laminin N-terminalInterPro annotationAdd BLAST240
Domaini283 – 346Laminin EGF-likeInterPro annotationAdd BLAST64
Domaini347 – 409Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini410 – 469Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini470 – 521Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini522 – 562Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini561 – 777Laminin IV type BInterPro annotationAdd BLAST217
Domaini783 – 830Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini831 – 876Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini877 – 926Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini927 – 985Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini986 – 1037Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1038 – 1094Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1095 – 1142Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1143 – 1189Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1201 – 1221Sequence analysisAdd BLAST21
Coiled coili1255 – 1296Sequence analysisAdd BLAST42
Coiled coili1477 – 1525Sequence analysisAdd BLAST49
Coiled coili1573 – 1617Sequence analysisAdd BLAST45
Coiled coili1724 – 1786Sequence analysisAdd BLAST63

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00780000121851
InParanoidiH2QMK9
KOiK06243
OMAiGACICKH
OrthoDBiEOG091G009B
TreeFamiTF312903

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 9 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

H2QMK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTSRERGR GQPLPWELRL GLLLSVLAAT LAQAPAPDVP GCSRGSCYPA
60 70 80 90 100
TGDLLVGRAD RLTASSTCGL NGPQPYCIVS HLQDEKKCFL CDSRRPFSAR
110 120 130 140 150
DNPHSHRIQN VVTSFAPQRR TAWWQSENGI PVVTIQLDLE AEFHFTHLIM
160 170 180 190 200
TFKTFRPAAM LVERSADFGR TWHVYRYFSY DCGADFPGVP LAPPRHWDDV
210 220 230 240 250
VCESRYSEIE PSTEGEVIYR VLDPAIPIPD PYSSRIQNLL KITNLRVNLT
260 270 280 290 300
RLHTLGDNLL DPRREIREKY YYALYELVVR GNCFCYGHAS ECAPAPGAPA
310 320 330 340 350
HAEGMVHGAC ICKHNTRGLN CEQCQDFYRD LPWHPAEDGH SHACRKCECH
360 370 380 390 400
GHTHSCHFDM AVYLASGNVS GGVCDGCQHN TAGRHCELCR PFFYRDPTKD
410 420 430 440 450
LRDPAVCRSC DCDPMGSQDG GRCDSHDDPA LGLVSGQCRC KEHVVGTRCQ
460 470 480 490 500
QCRDGFFGLS ISDPLGCRRC QCNARGTVPG STPCDPNSGS CYCKRLVTGR
510 520 530 540 550
GCDRCLPGHW GLSHDLLGCR PCDCDVGGAL DPQCDEGTGQ CHCRQHMVGR
560 570 580 590 600
RCEQVQPGYF RPFLDHLIWE AEDTRGQVLD VVERLVTPGE TPSWTGSGFV
610 620 630 640 650
RLQEGQTLEF LVASVPKAMD YDLLLRLEPQ VPEQWAELEL IVQRPGPVPA
660 670 680 690 700
HSLCGHLVPK DDRIQGTLQP HARYLIFPNP VCLEPGISYK LHLKLIRTGG
710 720 730 740 750
SAQPETPYSG PGLLIDSLVL LPRVLVLEMF SGGDAAALER QATFERYQCH
760 770 780 790 800
EEGLVPSKTS PSEACAPLFI SLSTLIYNGA LPCQCNPQGS LSSECNPHGG
810 820 830 840 850
QCLCKPGVVG RRCDLCAPGY YGFGPTGCQA CQCSHEGALS SLCEKTSGQC
860 870 880 890 900
LCRTGAFGLR CDRCQRGQWG FPSCRPCVCN GHADECNTHT GACLGCRDHT
910 920 930 940 950
GGEHCERCIA GFHGDPRLPY GGQCRPCPCP EGPGSQRHFA TSCHRDEYSQ
960 970 980 990 1000
QIVCHCRAGY TGLRCEACAP GHFGDPSRPG GRCQLCECSG NIDPMDPDAC
1010 1020 1030 1040 1050
DPHTGQCLRC LHHTEGPHCA HCKPGFHGQA ARQSCHRCTC NLLGTNPQQC
1060 1070 1080 1090 1100
PSPDQCHCDP SSGQCPCLPN VQGPSCDRCA PNFWNFTSGH GCQPCACHPS
1110 1120 1130 1140 1150
RARGPTCNEF TGQCHCRAGF GGRTCSECQE LHWGDPGLQC RACDCDSRGI
1160 1170 1180 1190 1200
DTPQCHRFTG HCSCRPGVSG VRCDQCARGF SGIFPACHPC HACFGDWDRV
1210 1220 1230 1240 1250
VQDLAARTRR LEQRAQELQQ TGVLGAFESS FWHMQEKLGI VQGIVGARNT
1260 1270 1280 1290 1300
SAASTAQLVE ATEELRREIE EATEHLTQLE AELTDVQDEN FNANHALSGL
1310 1320 1330 1340 1350
ERDTLALNLT LRQLDQHLDL LKHSNFLGAY DSIRHAHSQS AEAERRANTS
1360 1370 1380 1390 1400
ALAVPSPVSN SASARHRTEA LMDAQKEDFN SKHMANQRAL GKLSAHTHTL
1410 1420 1430 1440 1450
SLTDINELVC GAPGDAPCAT SPCGGAGCRD EDGQPRCGGL SCNGAAATAD
1460 1470 1480 1490 1500
LALGRARHTQ AELQRALAEG GSILSRVAET RRQASEAQQR AQAALDKANA
1510 1520 1530 1540 1550
SRGQVEQANQ ELRELIQSVK DFLNQEGADP DSIEMVATRV LELSIPASAE
1560 1570 1580 1590 1600
QIQHLAGAIA ERVRSLADVD AILARTVGDV RRAEQLLQDA RRARSWAEDE
1610 1620 1630 1640 1650
KQKAETVQAA LEEAQRAQGI AQGAIRGAVA DTRDTEQTLY QVQERMAGAE
1660 1670 1680 1690 1700
QALSSAGERA RQLDALLEAL KLKRAGNSLA ASTAEEMAGS AQGRAQEAEQ
1710 1720 1730 1740 1750
LLRGPLGDQY QTVKALAERK AQGVLAAQAR AEQLRDEARD LLQAAQDKLQ
1760 1770 1780 1790
RLQELEGTYE ENERALESKA AQLDGLEARM RSVLQAINLQ VQIYNTCQ
Length:1,798
Mass (Da):196,179
Last modified:February 28, 2018 - v2
Checksum:i46009188D70AAEA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04000312 Genomic DNA No translation available.
RefSeqiXP_016796574.1, XM_016941085.1

Genome annotation databases

EnsembliENSPTRT00000027916; ENSPTRP00000025746; ENSPTRG00000014912
GeneIDi460365
KEGGiptr:460365

Similar proteinsi

Entry informationi

Entry nameiH2QMK9_PANTR
AccessioniPrimary (citable) accession number: H2QMK9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: June 20, 2018
This is version 36 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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