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Protein
Submitted name:

6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4

Gene

PFKFB4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • 6-phosphofructo-2-kinase activity Source: GO_Central
  • ATP binding Source: InterPro
  • fructose-2,6-bisphosphate 2-phosphatase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4Imported
Submitted name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4Imported
Submitted name:
PFKFB4 isoform 8Imported
Gene namesi
Name:PFKFB4Imported
ORF Names:CK820_G0005153Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:9689 PFKFB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSPTRG00000014889 Expressed in 6 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025688

Structurei

3D structure databases

SMRiH2QMJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 2496PF2KInterPro annotationAdd BLAST215

Phylogenomic databases

eggNOGiKOG0234 Eukaryota
COG0406 LUCA
GeneTreeiENSGT00390000018751
KOiK19030
OMAiRIECYKN
OrthoDBiEOG091G0A43
TreeFamiTF313541

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H2QMJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR
60 70 80 90 100
GKTYISKKLT RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL
110 120 130 140 150
KIRKQCALAA LRDVRRFLSE EGGHVAVFDA TNTTRERRAT IFNFGEQNGY
160 170 180 190 200
KTFFVESICV DPEVIAANIV QVKLGSPDYV NRDSDEATED FMRRIECYEN
210 220 230 240 250
SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY YLMNIHVTPR
260 270 280 290 300
SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW
310 320 330 340 350
TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDNYPLEFAL
360 370 380 390 400
RDQDKYRYRY PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA
410 420 430 440 450
YFLDKAAEQL PYLKCPLHTV LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ
460
NVDISRPPEE ALVTVPAHQ
Length:469
Mass (Da):54,040
Last modified:March 21, 2012 - v1
Checksum:i7E190C3C0A197D9F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3RFQ5A0A2I3RFQ5_PANTR
6-phosphofructo-2-kinase/fructose-2...
PFKFB4 CK820_G0005153
434Annotation score:
A0A2I3TJV4A0A2I3TJV4_PANTR
6-phosphofructo-2-kinase/fructose-2...
PFKFB4
330Annotation score:
A0A2I3SD17A0A2I3SD17_PANTR
6-phosphofructo-2-kinase/fructose-2...
PFKFB4
372Annotation score:
A0A2I3T3F7A0A2I3T3F7_PANTR
6-phosphofructo-2-kinase/fructose-2...
PFKFB4
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04000308 Genomic DNA No translation available.
AC191234 Genomic DNA No translation available.
GABC01010038 mRNA Translation: JAA01300.1
NBAG03000218 Genomic DNA Translation: PNI80819.1
RefSeqiXP_001158394.1, XM_001158394.5

Genome annotation databases

EnsembliENSPTRT00000027852; ENSPTRP00000025688; ENSPTRG00000014889
GeneIDi460346
KEGGiptr:460346

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04000308 Genomic DNA No translation available.
AC191234 Genomic DNA No translation available.
GABC01010038 mRNA Translation: JAA01300.1
NBAG03000218 Genomic DNA Translation: PNI80819.1
RefSeqiXP_001158394.1, XM_001158394.5

3D structure databases

SMRiH2QMJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000025688

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000027852; ENSPTRP00000025688; ENSPTRG00000014889
GeneIDi460346
KEGGiptr:460346

Organism-specific databases

CTDi5210
VGNCiVGNC:9689 PFKFB4

Phylogenomic databases

eggNOGiKOG0234 Eukaryota
COG0406 LUCA
GeneTreeiENSGT00390000018751
KOiK19030
OMAiRIECYKN
OrthoDBiEOG091G0A43
TreeFamiTF313541

Gene expression databases

BgeeiENSPTRG00000014889 Expressed in 6 organ(s), highest expression level in testis

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2QMJ4_PANTR
AccessioniPrimary (citable) accession number: H2QMJ4
Secondary accession number(s): A0A2J8P9X2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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