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Entry version 58 (16 Oct 2019)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

ZBTB21 isoform 1

Gene

ZNF295

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ZBTB21 isoform 1Imported
Submitted name:
ZBTB21 isoform 3Imported
Submitted name:
ZBTB21 isoform 4Imported
Submitted name:
ZBTB21 isoform 5Imported
Submitted name:
Zinc finger protein 295Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF295Imported
ORF Names:CK820_G0022861Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSPTRG00000013933 Expressed in 6 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9598.ENSPTRP00000023977

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 96BTBInterPro annotationAdd BLAST67
Domaini546 – 574C2H2-typeInterPro annotationAdd BLAST29
Domaini670 – 697C2H2-typeInterPro annotationAdd BLAST28
Domaini775 – 803C2H2-typeInterPro annotationAdd BLAST29
Domaini909 – 936C2H2-typeInterPro annotationAdd BLAST28
Domaini937 – 964C2H2-typeInterPro annotationAdd BLAST28
Domaini1043 – 1066C2H2-typeInterPro annotationAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 196DisorderedSequence analysisAdd BLAST43
Regioni388 – 442DisorderedSequence analysisAdd BLAST55
Regioni454 – 485DisorderedSequence analysisAdd BLAST32
Regioni500 – 525DisorderedSequence analysisAdd BLAST26
Regioni806 – 844DisorderedSequence analysisAdd BLAST39
Regioni879 – 906DisorderedSequence analysisAdd BLAST28
Regioni963 – 1014DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 184PolarSequence analysisAdd BLAST31
Compositional biasi389 – 403PolyampholyteSequence analysisAdd BLAST15
Compositional biasi406 – 421PolarSequence analysisAdd BLAST16
Compositional biasi466 – 485PolyampholyteSequence analysisAdd BLAST20
Compositional biasi820 – 844PolarSequence analysisAdd BLAST25
Compositional biasi978 – 999Pro-richSequence analysisAdd BLAST22

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331184

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR041011 Znf_C2H2_6
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
PF18450 zf_C2H2_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2QL22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA
60 70 80 90 100
SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA
110 120 130 140 150
AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI
160 170 180 190 200
VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN
210 220 230 240 250
LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE
260 270 280 290 300
AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG
310 320 330 340 350
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV
360 370 380 390 400
PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ
410 420 430 440 450
VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD
460 470 480 490 500
AAATAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN
510 520 530 540 550
EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH
560 570 580 590 600
CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI
610 620 630 640 650
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS
660 670 680 690 700
SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV
710 720 730 740 750
NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC
760 770 780 790 800
PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ
810 820 830 840 850
NNMAPTENLS LPVLDHNGDV TGSSRPQSQA EPNKVNHIVT TKDDNVFSDS
860 870 880 890 900
SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA
910 920 930 940 950
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF
960 970 980 990 1000
RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE
1010 1020 1030 1040 1050
PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR
1060
TFKTAFSLWS HEQTHN
Length:1,066
Mass (Da):118,780
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA19A59A3667BDD5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GABF01001881 mRNA Translation: JAA20264.1
GABD01005887 mRNA Translation: JAA27213.1
GABD01005886 mRNA Translation: JAA27214.1
GABE01006874 mRNA Translation: JAA37865.1
NBAG03000265 Genomic DNA Translation: PNI55715.1
NBAG03000265 Genomic DNA Translation: PNI55717.1
NBAG03000265 Genomic DNA Translation: PNI55718.1
NBAG03000265 Genomic DNA Translation: PNI55719.1

NCBI Reference Sequences

More...
RefSeqi
XP_009432855.1, XM_009434580.2
XP_009432913.1, XM_009434638.2
XP_009432975.1, XM_009434700.2
XP_009433038.1, XM_009434763.2
XP_009433077.1, XM_009434802.2
XP_016794062.1, XM_016938573.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
458576

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABF01001881 mRNA Translation: JAA20264.1
GABD01005887 mRNA Translation: JAA27213.1
GABD01005886 mRNA Translation: JAA27214.1
GABE01006874 mRNA Translation: JAA37865.1
NBAG03000265 Genomic DNA Translation: PNI55715.1
NBAG03000265 Genomic DNA Translation: PNI55717.1
NBAG03000265 Genomic DNA Translation: PNI55718.1
NBAG03000265 Genomic DNA Translation: PNI55719.1
RefSeqiXP_009432855.1, XM_009434580.2
XP_009432913.1, XM_009434638.2
XP_009432975.1, XM_009434700.2
XP_009433038.1, XM_009434763.2
XP_009433077.1, XM_009434802.2
XP_016794062.1, XM_016938573.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000023977

Genome annotation databases

GeneIDi458576

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49854

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
OrthoDBi1318335at2759
TreeFamiTF331184

Gene expression databases

BgeeiENSPTRG00000013933 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR041011 Znf_C2H2_6
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
PF18450 zf_C2H2_6, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2QL22_PANTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2QL22
Secondary accession number(s): A0A2J8M883
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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