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Protein

Kynurenine formamidase

Gene

AFMID

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (TDO2)
  2. Kynurenine formamidase (AFMID), Kynurenine formamidase (AFMID)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164NucleophileUniRule annotation1
Active sitei247UniRule annotation1
Active sitei284UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processTryptophan catabolismUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00333;UER00454

Protein family/group databases

ESTHERipantr-h2qdz4 Kynurenine-formamidase

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:AFMIDUniRule annotationImported
ORF Names:CK820_G0040961Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:12025 AFMID

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiH2QDZ4

Expressioni

Gene expression databases

BgeeiENSPTRG00000009705 Expressed in 6 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016506

Structurei

3D structure databases

ProteinModelPortaliH2QDZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 257Abhydrolase_3InterPro annotationAdd BLAST166

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi95 – 99HGGXWUniRule annotation5

Domaini

The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.UniRule annotation

Sequence similaritiesi

Belongs to the kynurenine formamidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4627 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00390000011093
InParanoidiH2QDZ4
OMAiKEESGFM
OrthoDBiEOG091G0KT8
TreeFamiTF315112

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_03014 KFase, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR027519 KFase_ver/fungi-typ
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

H2QDZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDVSGVGFP SKVPWKKMSA EELENQYCPS RWVVRLGAEE ALRTYSQIGI
60 70 80 90 100
EATTRARATR KSLLHVPYGD GEGEKVDIYF PDESSEALPF FLFFHGGYWQ
110 120 130 140 150
SGSKDESAFM VDPLTAQGVA VVIVAYDIAP KGTLDHMVDQ VTRSVAFVQK
160 170 180 190 200
RYPSNKGIYL CGHSAGAHLA AMMLLADWTK HGVTPNLRGF FLVSGVFDLE
210 220 230 240 250
PIVYTSQNVA LQLTLEDAQR NSPQLKVAQA QPVDPTCRVL VVVGQFDSPE
260 270 280 290 300
FHRQSWEFYQ VLPAQTLCQG EWKASFEELH DVDHFEIVEN LIQKDNVLTQ

IILKTIFQ
Length:308
Mass (Da):34,548
Last modified:March 21, 2012 - v1
Checksum:iA1AA969FF9353058
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3RUX4A0A2I3RUX4_PANTR
Arylformamidase
AFMID
124Annotation score:
A0A2I3TH86A0A2I3TH86_PANTR
AFMID isoform 3
AFMID CK820_G0040961
60Annotation score:
A0A2I3SXB5A0A2I3SXB5_PANTR
AFMID isoform 11
AFMID CK820_G0040961
37Annotation score:
A0A2I3RAC9A0A2I3RAC9_PANTR
AFMID isoform 4
AFMID CK820_G0040961
84Annotation score:
A0A2I3RQ53A0A2I3RQ53_PANTR
AFMID isoform 8
AFMID CK820_G0040961
57Annotation score:
A0A2I3SR40A0A2I3SR40_PANTR
AFMID isoform 9
AFMID CK820_G0040961
93Annotation score:
A0A2I3SLY5A0A2I3SLY5_PANTR
Arylformamidase
AFMID
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04070029 Genomic DNA No translation available.
NBAG03000388 Genomic DNA Translation: PNI31090.1
RefSeqiXP_009431667.1, XM_009433392.2

Genome annotation databases

EnsembliENSPTRT00000017815; ENSPTRP00000016506; ENSPTRG00000009705
GeneIDi740879

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04070029 Genomic DNA No translation available.
NBAG03000388 Genomic DNA Translation: PNI31090.1
RefSeqiXP_009431667.1, XM_009433392.2

3D structure databases

ProteinModelPortaliH2QDZ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016506

Protein family/group databases

ESTHERipantr-h2qdz4 Kynurenine-formamidase

Proteomic databases

PaxDbiH2QDZ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000017815; ENSPTRP00000016506; ENSPTRG00000009705
GeneIDi740879

Organism-specific databases

CTDi125061
VGNCiVGNC:12025 AFMID

Phylogenomic databases

eggNOGiKOG4627 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00390000011093
InParanoidiH2QDZ4
OMAiKEESGFM
OrthoDBiEOG091G0KT8
TreeFamiTF315112

Enzyme and pathway databases

UniPathwayi
UPA00333;UER00454

Gene expression databases

BgeeiENSPTRG00000009705 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_03014 KFase, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR027519 KFase_ver/fungi-typ
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2QDZ4_PANTR
AccessioniPrimary (citable) accession number: H2QDZ4
Secondary accession number(s): A0A2J8K7U1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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