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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

GNG2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

GO - Molecular functioni

  • G-protein beta-subunit binding Source: GO_Central
  • GTPase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransducerUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gammaUniRule annotation
Gene namesi
Name:GNG2Imported
ORF Names:CK820_G0002437Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000006342 Expressed in 6 organ(s), highest expression level in testis

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000010751

Structurei

3D structure databases

SMRiH2Q8A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 71G protein gammaInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the G protein gamma family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
KOiK07826
OrthoDBiEOG091G17J0
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q8A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:March 21, 2012 - v1
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABC01002803 mRNA Translation: JAA08535.1
GABF01006290 mRNA Translation: JAA15855.1
GABD01009772 mRNA Translation: JAA23328.1
GABE01006034 mRNA Translation: JAA38705.1
NBAG03000214 Genomic DNA Translation: PNI83381.1
NBAG03000214 Genomic DNA Translation: PNI83382.1
NBAG03000214 Genomic DNA Translation: PNI83383.1
NBAG03000214 Genomic DNA Translation: PNI83384.1
NBAG03000214 Genomic DNA Translation: PNI83385.1
NBAG03000214 Genomic DNA Translation: PNI83386.1
RefSeqiXP_001158320.1, XM_001158320.4
XP_001158380.1, XM_001158380.3
XP_016781570.1, XM_016926081.1
XP_016781571.1, XM_016926082.1
XP_016781572.1, XM_016926083.1
XP_016781573.1, XM_016926084.1

Genome annotation databases

GeneIDi467457
KEGGiptr:467457

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABC01002803 mRNA Translation: JAA08535.1
GABF01006290 mRNA Translation: JAA15855.1
GABD01009772 mRNA Translation: JAA23328.1
GABE01006034 mRNA Translation: JAA38705.1
NBAG03000214 Genomic DNA Translation: PNI83381.1
NBAG03000214 Genomic DNA Translation: PNI83382.1
NBAG03000214 Genomic DNA Translation: PNI83383.1
NBAG03000214 Genomic DNA Translation: PNI83384.1
NBAG03000214 Genomic DNA Translation: PNI83385.1
NBAG03000214 Genomic DNA Translation: PNI83386.1
RefSeqiXP_001158320.1, XM_001158320.4
XP_001158380.1, XM_001158380.3
XP_016781570.1, XM_016926081.1
XP_016781571.1, XM_016926082.1
XP_016781572.1, XM_016926083.1
XP_016781573.1, XM_016926084.1

3D structure databases

SMRiH2Q8A8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000010751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi467457
KEGGiptr:467457

Organism-specific databases

CTDi54331

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
KOiK07826
OrthoDBiEOG091G17J0
TreeFamiTF319909

Gene expression databases

BgeeiENSPTRG00000006342 Expressed in 6 organ(s), highest expression level in testis

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2Q8A8_PANTR
AccessioniPrimary (citable) accession number: H2Q8A8
Secondary accession number(s): A0A2J8PH78
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 7, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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