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Protein

Alpha-1,4 glucan phosphorylase

Gene

PYGL

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.UniRule annotation

Catalytic activityi

((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
Biological processCarbohydrate metabolismUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,4 glucan phosphorylaseUniRule annotation (EC:2.4.1.1UniRule annotation)
Gene namesi
Name:PYGLImported
ORF Names:CK820_G0002409Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:48981 PYGL

Subcellular locationi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei681N6-(pyridoxal phosphate)lysineUniRule annotation1

Expressioni

Gene expression databases

BgeeiENSPTRG00000006337

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000010744

Structurei

3D structure databases

SMRiH2Q8A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycogen phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2099 Eukaryota
COG0058 LUCA
GeneTreeiENSGT00390000016886
KOiK00688
OMAiARDIWNM
OrthoDBiEOG091G03RB
TreeFamiTF300309

Family and domain databases

CDDicd04300 GT1_Glycogen_Phosphorylase, 1 hit
InterProiView protein in InterPro
IPR011833 Glycg_phsphrylas
IPR000811 Glyco_trans_35
IPR035090 Pyridoxal_P_attach_site
PANTHERiPTHR11468 PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343 Phosphorylase, 1 hit
PIRSFiPIRSF000460 Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093 P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102 PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q8A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPLTDQEK RRQISIRGIV GVENVAELKK SFNRHLHFTL VKDRNVATTR
60 70 80 90 100
DYYFALAHTV RDHLVGRWIR TQQHYYDKCP KRVYYLSLEF YMGRTLQNTM
110 120 130 140 150
INLGLQNACD EAIYQLGLDI EELEEIEEDA GLGNGGLGRL AACFLDSMAT
160 170 180 190 200
LGLAAYGYGI RYEYGIFNQK IRDGWQVEEA DDWLRYGNPW EKSRPEFMLP
210 220 230 240 250
VHFYGKVEHT NTGTKWIDTQ VVLALPYDTP VPGYMNNTVN TMRLWSARAP
260 270 280 290 300
NDFNLRDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
310 320 330 340 350
VAATLQDIIR RFKASKFGST RGAGTVFDAF PDQVAIQLND THPALAIPEL
360 370 380 390 400
MRIFVDIEKL PWSKAWELTQ KTFAYTNHTV LPEALERWPV DLVEKLLPRH
410 420 430 440 450
LEIIYEINQK HLDRIVALFP KDVDRLRRMS LIEEEGSKRI NMAHLCIVGS
460 470 480 490 500
HAVNGVAKIH SDIVKTKVFK DFSELEPDKF QNKTNGITPR RWLLLCNPGL
510 520 530 540 550
AELIAEKIGE DYVKDLSQLT KLHSFLGDDV FLRELAKVKQ ENKLKFSQFL
560 570 580 590 600
ETEYKVKINP SSMFDVQVKR IHEYKRQLLN CLHVITMYNR IKKDPKKLFV
610 620 630 640 650
PRTVIIGGKA APGYHMAKMI IKLITSVADV VNNDPMVGSK LKVIFLENYR
660 670 680 690 700
VSLAEKVIPA TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM
710 720 730 740 750
AEEAGEENLF IFGMRIDDVA ALDKKGYEAK EYYEALPELK LVIDQIDNGF
760 770 780 790 800
FSPKQPDLFK DIINMLFYHD RFKVFADYEA YVKCQDKVSQ LYMNPKAWNT
810 820 830 840
MVLKNIAASG KFSSDRTIKE YAQNIWNVEP SDLKISLSNE SNKVNGN
Length:847
Mass (Da):97,149
Last modified:March 21, 2012 - v1
Checksum:i74017E8125FB5735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04008566 Genomic DNA No translation available.
AACZ04008567 Genomic DNA No translation available.
GABC01000877 mRNA Translation: JAA10461.1
GABF01000679 mRNA Translation: JAA21466.1
NBAG03000214 Genomic DNA Translation: PNI83357.1
RefSeqiXP_001145433.2, XM_001145433.5

Genome annotation databases

EnsembliENSPTRT00000011605; ENSPTRP00000010744; ENSPTRG00000006337
GeneIDi742309
KEGGiptr:742309

Similar proteinsi

Entry informationi

Entry nameiH2Q8A4_PANTR
AccessioniPrimary (citable) accession number: H2Q8A4
Secondary accession number(s): A0A2J8PH76
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 18, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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