UniProtKB - H2Q867 (H2Q867_PANTR)
Protein
Submitted name:
NFKB inhibitor alpha
Gene
NFKBIA
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- NF-kappaB binding Source: Ensembl
- nuclear localization sequence binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cytoplasmic sequestering of NF-kappaB Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- negative regulation of lipid storage Source: Ensembl
- negative regulation of macrophage derived foam cell differentiation Source: Ensembl
- negative regulation of myeloid cell differentiation Source: Ensembl
- negative regulation of Notch signaling pathway Source: Ensembl
- nucleotide-binding oligomerization domain containing 1 signaling pathway Source: Ensembl
- nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
- positive regulation of cellular protein metabolic process Source: Ensembl
- positive regulation of cholesterol efflux Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein import into nucleus Source: Ensembl
- regulation of cell population proliferation Source: Ensembl
- response to exogenous dsRNA Source: Ensembl
- response to muramyl dipeptide Source: Ensembl
- response to muscle stretch Source: Ensembl
- toll-like receptor 4 signaling pathway Source: Ensembl
- tumor necrosis factor-mediated signaling pathway Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: NFKB inhibitor alphaImportedSubmitted name: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaImported |
Gene namesi | Name:NFKBIAImported |
Organismi | Pan troglodytes (Chimpanzee)Imported |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:8204, NFKBIA |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSPTRG00000006265, Expressed in placenta and 7 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- NF-kappaB binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000010634 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 256 | ANK_REP_REGIONInterPro annotationAdd BLAST | 184 | |
Repeati | 110 – 142 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 182 – 214 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 216 – 248 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 39 | PolyampholyteSequence analysisAdd BLAST | 29 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000162733 |
HOGENOMi | CLU_000134_6_3_1 |
OrthoDBi | 1341288at2759 |
TreeFami | TF320166 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H2Q867-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ
60 70 80 90 100
EIRLEPQEVP RGAEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD
110 120 130 140 150
LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL
160 170 180 190 200
ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE
210 220 230 240 250
LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG
260 270 280 290 300
YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE
310
DELPYDDCVF GGQRLTL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3S2B2 | A0A2I3S2B2_PANTR | NFKB inhibitor alpha | NFKBIA | 312 | Annotation score: | ||
A0A2I3RCC8 | A0A2I3RCC8_PANTR | NFKB inhibitor alpha | NFKBIA | 275 | Annotation score: | ||
A0A2I3TPB6 | A0A2I3TPB6_PANTR | NFKB inhibitor alpha | NFKBIA | 82 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACZ04059492 Genomic DNA No translation available. GABC01002360 mRNA Translation: JAA08978.1 GABC01002359 mRNA Translation: JAA08979.1 GABF01001925 mRNA Translation: JAA20220.1 GABD01008091 mRNA Translation: JAA25009.1 GABE01011322 mRNA Translation: JAA33417.1 GABE01011321 mRNA Translation: JAA33418.1 |
RefSeqi | XP_522823.2, XM_522823.5 |
Genome annotation databases
Ensembli | ENSPTRT00000011491; ENSPTRP00000010634; ENSPTRG00000006265 |
GeneIDi | 467426 |
KEGGi | ptr:467426 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACZ04059492 Genomic DNA No translation available. GABC01002360 mRNA Translation: JAA08978.1 GABC01002359 mRNA Translation: JAA08979.1 GABF01001925 mRNA Translation: JAA20220.1 GABD01008091 mRNA Translation: JAA25009.1 GABE01011322 mRNA Translation: JAA33417.1 GABE01011321 mRNA Translation: JAA33418.1 |
RefSeqi | XP_522823.2, XM_522823.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000010634 |
Genome annotation databases
Ensembli | ENSPTRT00000011491; ENSPTRP00000010634; ENSPTRG00000006265 |
GeneIDi | 467426 |
KEGGi | ptr:467426 |
Organism-specific databases
CTDi | 4792 |
VGNCi | VGNC:8204, NFKBIA |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000162733 |
HOGENOMi | CLU_000134_6_3_1 |
OrthoDBi | 1341288at2759 |
TreeFami | TF320166 |
Gene expression databases
Bgeei | ENSPTRG00000006265, Expressed in placenta and 7 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2Q867_PANTR | |
Accessioni | H2Q867Primary (citable) accession number: H2Q867 Secondary accession number(s): A0A2J8MI25 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 21, 2012 |
Last sequence update: | March 21, 2012 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |