UniProtKB - H2Q867 (H2Q867_PANTR)

>tr|H2Q867|H2Q867_PANTR NFKB inhibitor alpha OS=Pan troglodytes OX=9598 GN=NFKBIA PE=2 SV=1
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
RGAEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
DELPYDDCVFGGQRLTL

Entry version 47 (05 Jun 2019)
Sequence version 1 (21 Mar 2012)
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Protein

Submitted name:

NFKB inhibitor alpha

Gene

NFKBIA

Organism

Pan troglodytes (Chimpanzee)

Status

Unreviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
NF-kappaB binding Source: Ensembl
nuclear localization sequence binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic sequestering of NF-kappaB Source: Ensembl
I-kappaB kinase/NF-kappaB signaling Source: Ensembl
lipopolysaccharide-mediated signaling pathway Source: Ensembl
negative regulation of lipid storage Source: Ensembl
negative regulation of macrophage derived foam cell differentiation Source: Ensembl
negative regulation of myeloid cell differentiation Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
nucleotide-binding oligomerization domain containing 1 signaling pathway Source: Ensembl
nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
positive regulation of cellular protein metabolic process Source: Ensembl
positive regulation of cholesterol efflux Source: Ensembl
positive regulation of inflammatory response Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
protein import into nucleus Source: Ensembl
regulation of cell population proliferation Source: Ensembl
response to exogenous dsRNA Source: Ensembl
response to muramyl dipeptide Source: Ensembl
response to muscle stretch Source: Ensembl
toll-like receptor 4 signaling pathway Source: Ensembl
tumor necrosis factor-mediated signaling pathway Source: Ensembl

Complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: NFKB inhibitor alphaImported Submitted name: NFKBIA isoform 1Imported Submitted name: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaImported
Gene namesⁱ	Name:NFKBIAImported ORF Names:CK820_G0020417Imported
Organismⁱ	Pan troglodytes (Chimpanzee)Imported
Taxonomic identifierⁱ	9598 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan
Proteomesⁱ	UP000002277 Componentⁱ: Chromosome 14

Organism-specific databases

VGNCⁱ	VGNC:8204 NFKBIA

VGNCⁱ

VGNC:8204 NFKBIA

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSPTRG00000006265 Expressed in 6 organ(s), highest expression level in liver

Bgeeⁱ

ENSPTRG00000006265 Expressed in 6 organ(s), highest expression level in liver

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
NF-kappaB binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9598.ENSPTRP00000010634

STRINGⁱ

9598.ENSPTRP00000010634

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	73 – 256	ANK_REP_REGIONInterPro annotationAdd BLAST	184
Repeatⁱ	110 – 142	ANKPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	182 – 214	ANKPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	216 – 248	ANKPROSITE-ProRule annotationAdd BLAST	33

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 39	DisorderedSequence analysisAdd BLAST		39

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	11 – 39	PolyampholyteSequence analysisAdd BLAST		29

Keywords - Domainⁱ

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000162733
KEGG Orthology (KO) More...KOⁱ	K04734
Database of Orthologous Groups More...OrthoDBⁱ	1341288at2759
TreeFamⁱ	TF320166

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00023 Ank, 1 hit PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 5 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

H2Q867-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ 
        60         70         80         90        100
EIRLEPQEVP RGAEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD 
       110        120        130        140        150
LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL 
       160        170        180        190        200
ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE 
       210        220        230        240        250
LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG 
       260        270        280        290        300
YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE 
       310 
DELPYDDCVF GGQRLTL

Length:317

Mass (Da):35,593

Last modified:March 21, 2012 - v1

Checksum:ⁱ088B3F882678674F

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2I3S2B2	A0A2I3S2B2_PANTR	NFKB inhibitor alpha NFKB inhibitor alpha	NFKBIA	312	Annotation score:
A0A2I3RCC8	A0A2I3RCC8_PANTR	NFKB inhibitor alpha NFKB inhibitor alpha	NFKBIA	275	Annotation score:
A0A2I3TPB6	A0A2I3TPB6_PANTR	NFKB inhibitor alpha NFKB inhibitor alpha (NFKBIA isoform 2)	NFKBIA CK820_G0020417	82	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AACZ04059492 Genomic DNA No translation available. GABC01002360 mRNA Translation: JAA08978.1 GABC01002359 mRNA Translation: JAA08979.1 GABF01001925 mRNA Translation: JAA20220.1 GABD01008091 mRNA Translation: JAA25009.1 GABE01011322 mRNA Translation: JAA33417.1 GABE01011321 mRNA Translation: JAA33418.1 NBAG03000256 Genomic DNA Translation: PNI59175.1
NCBI Reference Sequences More...RefSeqⁱ	XP_522823.2, XM_522823.5

Genome annotation databases

Ensemblⁱ	ENSPTRT00000011491; ENSPTRP00000010634; ENSPTRG00000006265
GeneIDⁱ	467426
KEGGⁱ	ptr:467426

Protein	Similar proteins		Species	Score	Length	Source
H2Q867	NF-kappa-B inhibitor alpha		MACMU		317	UniRef100_H9FUW3
Macaca fascicularis brain cDNA clone: QflA-18741, similar to human nuclear factor of kappa light polypeptide gene enhancerin B-cells inhibitor, alpha (NFKBIA), mRNA, RefSeq: NM_020529.1		MACFA		317
Uncharacterized protein		CERAT		317
Uncharacterized protein		PAPAN		317
NFKB inhibitor alpha		GORGO		317
+1

Protein	Similar proteins		Species	Score	Length	Source
H2Q867	NF-kappa-B inhibitor alpha	)	HUMAN		317	UniRef90_P25963
Uncharacterized protein		RHIRO		343
Uncharacterized protein		PANPA		317
Uncharacterized protein		COLAP		317
Uncharacterized protein		RHIBE		317
+36

Protein	Similar proteins		Species	Score	Length	Source
H2Q867	NF-kappa-B inhibitor alpha	)	HUMAN		317	UniRef50_P25963
NF-kappa-B inhibitor alpha		CHICK		318
NF-kappa-B inhibitor alpha		RAT		314
NF-kappa-B inhibitor alpha		MOUSE		314
Uncharacterized protein		RHIRO		343
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AACZ04059492 Genomic DNA No translation available. GABC01002360 mRNA Translation: JAA08978.1 GABC01002359 mRNA Translation: JAA08979.1 GABF01001925 mRNA Translation: JAA20220.1 GABD01008091 mRNA Translation: JAA25009.1 GABE01011322 mRNA Translation: JAA33417.1 GABE01011321 mRNA Translation: JAA33418.1 NBAG03000256 Genomic DNA Translation: PNI59175.1
RefSeqⁱ	XP_522823.2, XM_522823.5

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	9598.ENSPTRP00000010634

STRINGⁱ

9598.ENSPTRP00000010634

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSPTRT00000011491; ENSPTRP00000010634; ENSPTRG00000006265
GeneIDⁱ	467426
KEGGⁱ	ptr:467426

Organism-specific databases

CTDⁱ	4792
VGNCⁱ	VGNC:8204 NFKBIA

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
GeneTreeⁱ	ENSGT00940000162733
KOⁱ	K04734
OrthoDBⁱ	1341288at2759
TreeFamⁱ	TF320166

Gene expression databases

Bgeeⁱ	ENSPTRG00000006265 Expressed in 6 organ(s), highest expression level in liver

Bgeeⁱ

ENSPTRG00000006265 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
Pfamⁱ	View protein in Pfam PF00023 Ank, 1 hit PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 5 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2Q867_PANTR
Accessionⁱ	H2Q867Primary (citable) accession number: H2Q867 Secondary accession number(s): A0A2J8MI25
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 21, 2012
	Last sequence update:	March 21, 2012
	Last modified:	June 5, 2019
	This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H2Q867 (H2Q867_PANTR)

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NFKB inhibitor alpha

NFKBIA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Plasma Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ