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Protein
Submitted name:

PTGS2 isoform 1

Gene

PTGS2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
PTGS2 isoform 1Imported
Submitted name:
Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)Imported
Gene namesi
Name:PTGS2Imported
ORF Names:CK820_G0013506Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:6970 PTGS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501509235224 – 604Sequence analysisAdd BLAST581

Expressioni

Gene expression databases

BgeeiENSPTRG00000001786 Expressed in 5 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000002990

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 55EGF-likeInterPro annotationAdd BLAST39

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
KOiK11987
OMAiCNNVKGC
OrthoDBiEOG091G03CD
TreeFamiTF329675

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR029576 COX-2
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF8 PTHR11903:SF8, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00008 EGF, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q0S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS
110 120 130 140 150
YVLTSRSHLI DSPPTYNADY GYKSWEAFSN LSYYTRALPP VPDDCPTPLG
160 170 180 190 200
VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTNGL GHGVDLNHIY GETLARQHKL RLFKDGKMKY QIIDGEMYPP
260 270 280 290 300
TVKDTQAEMI YPPQVPEHLR FAVGQEFFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNKQFQYQ NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL
410 420 430 440 450
LEHGITQFVE SFTRQIAGRV AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN
460 470 480 490 500
EYRKRFMLKP YESFEELTGE KEMSAELEAL YGDIDAVELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV GFQIINTASI
560 570 580 590 600
QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):69,025
Last modified:March 21, 2012 - v1
Checksum:i0362AC245F1785E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04056148 Genomic DNA No translation available.
GABC01002551 mRNA Translation: JAA08787.1
GABF01006138 mRNA Translation: JAA16007.1
GABE01001405 mRNA Translation: JAA43334.1
NBAG03000235 Genomic DNA Translation: PNI67303.1
RefSeqiXP_524999.3, XM_524999.6

Genome annotation databases

EnsembliENSPTRT00000003246; ENSPTRP00000002990; ENSPTRG00000001786
GeneIDi469616
KEGGiptr:469616

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04056148 Genomic DNA No translation available.
GABC01002551 mRNA Translation: JAA08787.1
GABF01006138 mRNA Translation: JAA16007.1
GABE01001405 mRNA Translation: JAA43334.1
NBAG03000235 Genomic DNA Translation: PNI67303.1
RefSeqiXP_524999.3, XM_524999.6

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000002990

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000003246; ENSPTRP00000002990; ENSPTRG00000001786
GeneIDi469616
KEGGiptr:469616

Organism-specific databases

CTDi5743
VGNCiVGNC:6970 PTGS2

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
KOiK11987
OMAiCNNVKGC
OrthoDBiEOG091G03CD
TreeFamiTF329675

Gene expression databases

BgeeiENSPTRG00000001786 Expressed in 5 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR029576 COX-2
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF8 PTHR11903:SF8, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00008 EGF, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2Q0S9_PANTR
AccessioniPrimary (citable) accession number: H2Q0S9
Secondary accession number(s): A0A2J8N6A4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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