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Entry version 43 (31 Jul 2019)
Sequence version 2 (09 Jan 2013)
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Protein

ANK_REP_REGION domain-containing protein

Gene

BCORL1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCORL1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000023186

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1461 – 1569ANK_REP_REGIONInterPro annotationAdd BLAST109
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1495 – 1527ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1528 – 1560ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 104DisorderedSequence analysisAdd BLAST76
Regioni309 – 334DisorderedSequence analysisAdd BLAST26
Regioni493 – 516DisorderedSequence analysisAdd BLAST24
Regioni528 – 612DisorderedSequence analysisAdd BLAST85
Regioni719 – 747DisorderedSequence analysisAdd BLAST29
Regioni842 – 867DisorderedSequence analysisAdd BLAST26
Regioni902 – 943DisorderedSequence analysisAdd BLAST42
Regioni1073 – 1175DisorderedSequence analysisAdd BLAST103
Regioni1189 – 1259DisorderedSequence analysisAdd BLAST71
Regioni1278 – 1453DisorderedSequence analysisAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 63PolyampholyteSequence analysisAdd BLAST19
Compositional biasi493 – 507PolarSequence analysisAdd BLAST15
Compositional biasi530 – 544Pro-richSequence analysisAdd BLAST15
Compositional biasi550 – 568PolarSequence analysisAdd BLAST19
Compositional biasi588 – 602PolarSequence analysisAdd BLAST15
Compositional biasi1077 – 1097PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1153 – 1175PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1241 – 1259PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1305 – 1340PolyampholyteSequence analysisAdd BLAST36
Compositional biasi1352 – 1366PolarSequence analysisAdd BLAST15
Compositional biasi1391 – 1406PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1425 – 1443PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFKH Eukaryota
ENOG411028G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2PWR4

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVEFQSW

TreeFam database of animal gene trees

More...
TreeFami
TF333317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032365 PUFD
IPR038227 PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF16553 PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2PWR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSQRQATAS TLDLREFCVS SSFSKVELTA VGSGSNARGA DPDGSATEKL
60 70 80 90 100
GHKSEDKPDD PQPKMDYAGN VAEAEGLLVP LSSPGDGLKL PASDSAEASN
110 120 130 140 150
SRADCSWTPL NTQMSKQVDC SPAGVKALDS RQGVGEKNTF ILATLGTGVP
160 170 180 190 200
VEGTLPLVTT NFSPLPAPIC PPAPGSASVP PSVPDAFQVP LSVPAPVPHS
210 220 230 240 250
GLVPVQVATS VPAPSPPLAP VPALAPAPPS VPTLISDSNP LSVSASVLVP
260 270 280 290 300
VPASAPPSGP VPLSAPAPAP LSVPVSAPPL ALIQAPVPPS APTLVLAPVP
310 320 330 340 350
TPVLAPMPAS TPPAAPAPPS VPMPTPTPSS GPPSTPTLIP AFAPTPVPAP
360 370 380 390 400
TPAPIFTPAP TPMPAATPAA IPTSAPIPAS FSLSRVCFPA AQAPAMQKVP
410 420 430 440 450
VSFQPGTVLT PSQPLVYIPP PSCGQPLSVA TLPTTLGVSS TLTLPVLPSY
460 470 480 490 500
LQDRCLPGVL ASPELRSYPY AFSVARPLTS DSKLVSLEVN RLPCTSPSGS
510 520 530 540 550
TTTQPAPDGV PGPLADTSLV TASAKVLPTP QPLLPAPSGS SAPPHPAKMP
560 570 580 590 600
SGTEQQTEGT SVTFSPLKSP PQLEREMASP PECSEMPLDL SSKSNRQKLP
610 620 630 640 650
LPNQRKTPPM PVLTPVHTSS KAFLSTVLSR SQRTTQAAGG NVTSCLGSTS
660 670 680 690 700
SPFVIFPEIV RNGDPSTWVK NSTALISTIP GTYVGVANPV PASLLLNKDP
710 720 730 740 750
NLGLNRDPRH LPKQEPISII DQGEPKGTGA ACGKKGSQAG AEGQPSTVKR
760 770 780 790 800
YTPARIAPGL PGCQTKELSL WKPTGPANIY PRCSVNGKPT STQVLPVGWS
810 820 830 840 850
PYHQASLLSI GISSAGQLTP SQGAPIRPTS VVSEFSGVPS LSSSEAVHGL
860 870 880 890 900
PEGQPRPGGS FVPEQDPVTK NKTCRIAAKP YEEQVSPVLL TLSPQTGTLA
910 920 930 940 950
LSVQPSGGDI RMNQGPEESE SHLCSDSTPK MEGPQGACGL KLAGDTKPKN
960 970 980 990 1000
QVLATYMSHE LVLATPQNLP KMPELPLLPH DSHPKELILD VVPSSRRGSS
1010 1020 1030 1040 1050
TERPQLGSQV DLGRVKMEKV DGDVVFNLAT CFRADGLPVA PQRGQAEVRA
1060 1070 1080 1090 1100
KAGQARVKQE SVGVFACKNK WQPDDVTESL PPKKMKCGKE KDSEEQQLQP
1110 1120 1130 1140 1150
QAKAMVRSSH RPKCRKLPSD PQESTKKSPR GASDSGKEHN GVRGKHKHRK
1160 1170 1180 1190 1200
PTKPESQSPG KRADGHEEGS LEKKAKSSFR DFIPVVLSTR TRSQSGSICS
1210 1220 1230 1240 1250
SFAGMADSDM GSQEVFPTEE EEEVTPTPAK RRKVRKTQRD TQYRSHHAQD
1260 1270 1280 1290 1300
KSLLSQGRRH LWRAREMPWR TEAARQMWDT NEEEEEEEEE GLLKRKKRRR
1310 1320 1330 1340 1350
QKSRKYQTGE YLTEQEDEQR RKGRADLKAR KQKTSSSQSL EHRLRNRNLL
1360 1370 1380 1390 1400
LPNKVQGISD SPNGFLPNNL EEPACLENSE KPSGKRKCKT KHMATVSEEA
1410 1420 1430 1440 1450
KGKGRWNQQK TRSPKSPTPV KPTEPCTPSK SRSASSEEAS ESPTARQIPP
1460 1470 1480 1490 1500
EARRLIVNKN AGETLLQRAA RLGYKDVVLY CLQKDSEDVN HRDNAGYTAL
1510 1520 1530 1540 1550
HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND NLETIWLLLS
1560 1570 1580 1590 1600
YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE GDPGVSWDFY
1610 1620 1630 1640 1650
SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL SDKPLLPCYN
1660 1670 1680 1690 1700
LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT MPKAEFYRQV
1710 1720 1730 1740 1750
ASSQLLTPAE RPGGLDDRSP PGSSETVELV RYEPDLLRLL GSEVEFQSCN

S
Length:1,751
Mass (Da):186,775
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D45174261B786B6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABGA01181337 Genomic DNA No translation available.
ABGA01181338 Genomic DNA No translation available.
ABGA01181339 Genomic DNA No translation available.
ABGA01181340 Genomic DNA No translation available.
ABGA01181341 Genomic DNA No translation available.
ABGA01181342 Genomic DNA No translation available.
ABGA01181343 Genomic DNA No translation available.
ABGA01181344 Genomic DNA No translation available.
ABGA01181345 Genomic DNA No translation available.
ABGA01181346 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000024157; ENSPPYP00000023186; ENSPPYG00000020710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01181337 Genomic DNA No translation available.
ABGA01181338 Genomic DNA No translation available.
ABGA01181339 Genomic DNA No translation available.
ABGA01181340 Genomic DNA No translation available.
ABGA01181341 Genomic DNA No translation available.
ABGA01181342 Genomic DNA No translation available.
ABGA01181343 Genomic DNA No translation available.
ABGA01181344 Genomic DNA No translation available.
ABGA01181345 Genomic DNA No translation available.
ABGA01181346 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023186

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000024157; ENSPPYP00000023186; ENSPPYG00000020710

Phylogenomic databases

eggNOGiENOG410IFKH Eukaryota
ENOG411028G LUCA
GeneTreeiENSGT00940000153737
InParanoidiH2PWR4
OMAiEVEFQSW
TreeFamiTF333317

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR032365 PUFD
IPR038227 PUFD_som_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF16553 PUFD, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2PWR4_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2PWR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: July 31, 2019
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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