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Entry version 47 (05 Jun 2019)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

Dedicator of cytokinesis 11

Gene

DOCK11

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dedicator of cytokinesis 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000023128

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 272PHInterPro annotationAdd BLAST108
Domaini640 – 818DHR-1InterPro annotationAdd BLAST179
Domaini1601 – 2028DHR-2InterPro annotationAdd BLAST428

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1225 – 1266DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1250 – 1266PolarSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155658

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2PWK7

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGQVGDN

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697 C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2PWK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKVV EPLDYENVIA
60 70 80 90 100
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF
110 120 130 140 150
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC
160 170 180 190 200
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD
210 220 230 240 250
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH
260 270 280 290 300
YLAAETEQEM EEWLITLKKI IQINTDSLVQ EKKETVETAQ DDETSSQGKA
310 320 330 340 350
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS
360 370 380 390 400
GIEPDIKPFE EKCNKRFLVN CHDLTFNILG QIGDNAKGPP TNVEPFFINL
410 420 430 440 450
ALFDVKNNCK ISADFHIDLN PPSVREMLWG SSTQLASDGS PKGSSPESYI
460 470 480 490 500
HGIAESQLRY IQQGIFSVTN PHPEIFLVAR IEKVLQGNIT HCAEPYIKNS
510 520 530 540 550
DPVKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDTQG SLDLDGRFSP
560 570 580 590 600
LYKQDSSKLS SEDILKLLSE YKKPEKTKLQ IIPGQLNITV ECVPVDLSNC
610 620 630 640 650
ITSSYVPLKP FEKNCENITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL
660 670 680 690 700
KYDSQKTFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV
710 720 730 740 750
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT
760 770 780 790 800
VETPVGFAWV PLLKDGRIIT FEQQLPVSAN LPPGYLNLND AESRKQCNVD
810 820 830 840 850
IKWVDGAKPL LKIKSHLEST IYTDLHVHKF FHHCQLIQSG SKEVPGELIK
860 870 880 890 900
YLKCLHAMEI QVMIQFLPVI LMQLFRVLTN MTHEDDVPIN CTMVLLHIVS
910 920 930 940 950
KCHEEGLDSY LRSFIKYSFR PEKPSAPQAQ LIHETLATTM IAILKQSADF
960 970 980 990 1000
LSINKLLKYS WFFFEIIAKS MATYLLEENK IKLPRGQRFP ETYHHVLHSL
1010 1020 1030 1040 1050
LLAIIPHVTI RYAEIPDESR NVNYSLASFL KRCLTLMDRG FIFNLINDYI
1060 1070 1080 1090 1100
SGFSPKDPKV LAEYKFEFLQ TICNHEHYIP LNLPMAFAKP KLQRVQDSNL
1110 1120 1130 1140 1150
EYSLSDEYCK HHFLVGLLLR ETSIALQDNY EIRYTAISVI KNLLIKHAFD
1160 1170 1180 1190 1200
TRYQHKNQQA KIAQLYLPFV GLLLENIQRL AGRDTLYSCA AMPNSASRDE
1210 1220 1230 1240 1250
FPCGFTSPAN RGSLSTDKDT AYGSFQNGHG IKREDSRGSL IPEGATGFPD
1260 1270 1280 1290 1300
QGNTGENTRQ SSTRSSVSQY NRLDQYEIRS LLMCYLYIVK MISEDTLLTY
1310 1320 1330 1340 1350
WNKVSPQELI NILILLEVCL FHFRYMVHDA WLSKHFGIDR KSQTMPALRN
1360 1370 1380 1390 1400
RSGVMQARLQ HLSSLESSFT LNHGSTTTEA DIFHQALLEG NTATEVSLTV
1410 1420 1430 1440 1450
LDTISFFTQC FKTQLLNNDG HNPLMKKVFD IHLAFLKNGQ SEVSLKHVFA
1460 1470 1480 1490 1500
SLRAFISKFP SAFFKGRVNM CAAFCYEVLK CCTSKISSTR NEASALLYLL
1510 1520 1530 1540 1550
MRNNFEYTKR KTFLRTHLQI IIAVSQLIAD VALSGGSRFQ ESLFIINNFA
1560 1570 1580 1590 1600
NSDRPMKATA FPTEVKDLTK RIRTVLMATA QMKEHEKDPE MLIDLQYSLA
1610 1620 1630 1640 1650
KSYASTPELR KTWLDSMAKI HVKNGDFSEA AMCYVHVAAL VAEFLHRKKL
1660 1670 1680 1690 1700
FPNGCSAFKK ITPNIDEEGA MKEDAGMMDV HYSEEVLLEL LEQCVDGLWK
1710 1720 1730 1740 1750
AERYEIISEI SKLIIPIYEK RREFEKLTQV YRTLHGAYTK ILEVMHTKKR
1760 1770 1780 1790 1800
LLGTFFRVAF YGQSFFEEED GKEYIYKEPK LTGLSEISLR LVKLYGEKFG
1810 1820 1830 1840 1850
TENVKIIQDS DKVNAKELDP KYAHIQVTYV KPYFDDKELT ERKTEFERNH
1860 1870 1880 1890 1900
NISRFVFEAP YTLSGKKQGC IEEQCKRRTI LTTSNSFPYV KKRIPINCEQ
1910 1920 1930 1940 1950
QINLKPIDVA TDEIKDKTAE LQKLCSSTDV DMIQLQLKLQ GCVSVQVNAG
1960 1970 1980 1990 2000
PLAYARAFLN DSQASKYPPK KVSELKDMFR KFIQACSIAL ELNERLIKED
2010 2020 2030 2040 2050
QVEYHEGLKS NFRDMVKELS DIIHEQILQE DTMHSPWMSN TLHVFCAISG
2060
TSSDRGYGSP RYAEV
Length:2,065
Mass (Da):236,748
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EE4984C57E7B9DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABGA01332162 Genomic DNA No translation available.
ABGA01332163 Genomic DNA No translation available.
ABGA01332164 Genomic DNA No translation available.
ABGA01332165 Genomic DNA No translation available.
ABGA01332166 Genomic DNA No translation available.
ABGA01332167 Genomic DNA No translation available.
ABGA01332168 Genomic DNA No translation available.
ABGA01332169 Genomic DNA No translation available.
ABGA01332170 Genomic DNA No translation available.
ABGA01332171 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000024098; ENSPPYP00000023128; ENSPPYG00000020660

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01332162 Genomic DNA No translation available.
ABGA01332163 Genomic DNA No translation available.
ABGA01332164 Genomic DNA No translation available.
ABGA01332165 Genomic DNA No translation available.
ABGA01332166 Genomic DNA No translation available.
ABGA01332167 Genomic DNA No translation available.
ABGA01332168 Genomic DNA No translation available.
ABGA01332169 Genomic DNA No translation available.
ABGA01332170 Genomic DNA No translation available.
ABGA01332171 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023128

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000024098; ENSPPYP00000023128; ENSPPYG00000020660

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000155658
InParanoidiH2PWK7
OMAiLGQVGDN
TreeFamiTF313629

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2PWK7_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2PWK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: June 5, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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