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Protein
Submitted name:

TBC1 domain family member 8B

Gene

TBC1D8B

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TBC1 domain family member 8BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D8BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000023063

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini545 – 732Rab-GAP TBCInterPro annotationAdd BLAST188
Domaini916 – 951EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4347 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159451

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2PWE5

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRECSKT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00RI

TreeFam database of animal gene trees

More...
TreeFami
TF313145

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2PWE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLPTWERREG WGKCGKPEPE LLSPEEDLVG GEAEGKRRVE SEVRRASRSL
60 70 80 90 100
FPVGTKFAMW LKPEEVLLKN ALKLWLMERS NDYFVLQRRR GYGEEGGGGL
110 120 130 140 150
TGLLVGTLDS VLDSTAKVAP FRILHQTPDS QVYLSIACGA NREEITKHWD
160 170 180 190 200
WLEQNIMKTL SVFDSNEDIT NFVQGKIRGL IAEEGKHCFA KEDDPEKFRE
210 220 230 240 250
ALLKFEKCFG LPEKEKLVTY YSCSYWKGRV PCQGWLYLST NFLSFYSFLL
260 270 280 290 300
GSEIKLIISW DEVSKLEKTS NVILTESVHV CSQGENHYFS MFLHINQTYL
310 320 330 340 350
LMEQLANYAI RRLFDKETFD NDPVLYNPLQ ITKRGLENRA HSEQFNAFFR
360 370 380 390 400
LPKGESLKEV HECSLWVPFS HFNTHGKMCI SENYICFASQ DGNQCSVIIP
410 420 430 440 450
LREVLAIDKT NDSSKSVIIS IKGKTAFRFH EVKDFEQLVA KLRLRCGAAS
460 470 480 490 500
TQYHDISTEL AISSESTETS DNFEVQSLTS QRECSKTVNT EALMMVFHPQ
510 520 530 540 550
NLETLNSKML KEKMKEQSWK ILFAECGRGV SMFRTKKTRD LVVRGIPETL
560 570 580 590 600
RGELWMLFSG AVNDMATNPG YYTEVVEQSL GTCNLATEEI ERDLRRSLPE
610 620 630 640 650
HPAFQSDTGI SALRRVLTAY AYRNPKIGYC QAMNILTSVL LLYAKEEEAF
660 670 680 690 700
WLLVAVCERM LPDYFNRRII GALVDQAVFE ELIRDHLPQL TEHMTDMTFF
710 720 730 740 750
SSVSLSWFLT LFISVLPIES AVNVVDCFFY DGIKAILQLG LAILDYNLDK
760 770 780 790 800
LLTCKDDAEA VTALNRFFDN VTNKDSPLPS NVQQGSNVSD EKTSHTRVDI
810 820 830 840 850
TDLIRESNEK YGNIRYEDIH SMRCRNRLYV IQTLEETTKQ NVLRVVSQDV
860 870 880 890 900
KLSLHELDQL YVIFKKELFL SCYWCLGCPV LKHHDPSLPY LEQYQIDCQQ
910 920 930 940 950
FRALYHLLCP WAHSANRDSL ALWTFRLLDE NSDCLINFKE FSSAIDIMYN
960 970 980 990 1000
GSFTEKLKLL FKLHIPPAYT EVKSKDASKG DELSKEELLY FSQLRVSKPA
1010 1020 1030 1040 1050
NEKEAQSAKH SPEKGKGKID IQAYLSQWQD ELFKKEENIK DLPRMNQSQF
1060 1070 1080 1090 1100
IQFSKTLYNL FHEDPEEESL YQAIAVVTSL LLRMEEVGRK LHSPTSSAKG
1110 1120 1130 1140 1150
FSGTVCGSGG PSEEKTGSHL EKDPCSFREE PQWSFAFEQI LASLLNEPAL
1160 1170
VRFFEKPIDV KAKLENAKIS QLRSRTKM
Length:1,178
Mass (Da):135,133
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2C10702C123BB0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABGA01206444 Genomic DNA No translation available.
ABGA01206445 Genomic DNA No translation available.
ABGA01206446 Genomic DNA No translation available.
ABGA01206447 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000024033; ENSPPYP00000023063; ENSPPYG00000020605

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01206444 Genomic DNA No translation available.
ABGA01206445 Genomic DNA No translation available.
ABGA01206446 Genomic DNA No translation available.
ABGA01206447 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023063

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000024033; ENSPPYP00000023063; ENSPPYG00000020605

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000159451
InParanoidiH2PWE5
OMAiQRECSKT
OrthoDBiEOG091G00RI
TreeFamiTF313145

Family and domain databases

CDDicd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2PWE5_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2PWE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: December 5, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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