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Entry version 40 (16 Oct 2019)
Sequence version 2 (09 Jan 2013)
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Protein

Peptidase_M28 domain-containing protein

Gene

ERMP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidase_M28 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERMP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei494 – 512HelicalSequence analysisAdd BLAST19
Transmembranei524 – 550HelicalSequence analysisAdd BLAST27
Transmembranei562 – 585HelicalSequence analysisAdd BLAST24
Transmembranei597 – 619HelicalSequence analysisAdd BLAST23
Transmembranei625 – 643HelicalSequence analysisAdd BLAST19
Transmembranei655 – 678HelicalSequence analysisAdd BLAST24
Transmembranei698 – 720HelicalSequence analysisAdd BLAST23
Transmembranei727 – 749HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000021539

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 453Peptidase_M28InterPro annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 140DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi85 – 102PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2194 Eukaryota
COG2234 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063839

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2PS71

Identification of Orthologs from Complete Genome Data

More...
OMAi
ILNYMVA

TreeFam database of animal gene trees

More...
TreeFami
TF314836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007484 Peptidase_M28

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389 Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2PS71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYPPPAAGS ALQLCAPENC QRSWVLARRD RPIRRSLALC SFRPLTRRRC
60 70 80 90 100
GSDGGVGGRS CRGLGRLGWQ LRLLAMEWGS ESAAVRRHRV GGERREGAAA
110 120 130 140 150
APPPEREARA QEPLVDGCNG GGRTRKRSPG GSGSASRGAG TGLSEARAAL
160 170 180 190 200
GLALYLIALR TLVQLSLQQL VLRGAAGHRG EFDALQARDY LEHITSIGPR
210 220 230 240 250
TTGSPENEIL TVHYLLEQIK LIEVQSNSLH KISVDVQRPT GSFSIDFLGG
260 270 280 290 300
FTSYYDNITN IVVKLEPRDG AQHAVLANCH FDSVANSPGA SDDAVSCSVM
310 320 330 340 350
LEVLRVLSTS SEALHHAVIF LFNGAEENVL QASHGFITQH PWASLIRAFI
360 370 380 390 400
NLEAAGVGGK ELVFQTGPEN PWLVQAYVSA AKHPFASVVA QEVFQSGIIP
410 420 430 440 450
SDTDFRIYRD FGNIPGIDLA FIENGYIYHT KYDTADRILT DSIQRAGDNI
460 470 480 490 500
LAVLKHLATS DMLAAASKYR HGNVVFFDVL GLFVIAYPSR IGSIINYMVV
510 520 530 540 550
MGVVLYLGKK LLQPKHKTGN YKKDFLCGLG ITLISWFTSL VTVLIIAVFI
560 570 580 590 600
SLIGQSLSWY NHFYVSVCLY GTATVAKIIL IHTLAKRFYY MNASDQYLGE
610 620 630 640 650
VFFDISLFVH CCFLVTLTYQ GLCSAFISAV WVAFPLLTKL CGHKDFKQHG
660 670 680 690 700
AQGKFIAFYL LGMFIPYLYA LYLIWAVFEM FTPILGRSGS EIPPDVVLAS
710 720 730 740 750
ILAGCTMILS SYFINFIYLA KSTKKTMLTL TLVCAITFLL VCSGTFFPYS
760 770 780 790 800
SNPANPKPKR VFLQHMTRTF HDLEGNAVKR DSGIWINGFD YTGISHITPH
810 820 830 840 850
IPEINDSIRA HCEENAPLCG FPWYLPVHFL IRKNWYLPAP EVSPRNPPHF
860 870 880 890 900
RLISKEQTPW DSIKLTFEAT GPSHMSFYVR AHKGSTLSQW SLGNGTPVTS
910 920 930 940 950
KGGDYFVFYS HGLQASAWQF WIEVQVSEEH PEGMVTVAIA AHYLSGEDKR
960 970
SPQLDALKEK FPDWTFPSAW VCTYDLFVF
Length:979
Mass (Da):108,387
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96774DB436AD1163
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABGA01254907 Genomic DNA No translation available.
ABGA01254908 Genomic DNA No translation available.
ABGA01254909 Genomic DNA No translation available.
ABGA01254910 Genomic DNA No translation available.
ABGA01254911 Genomic DNA No translation available.
ABGA01254912 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000022419; ENSPPYP00000021539; ENSPPYG00000019234

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01254907 Genomic DNA No translation available.
ABGA01254908 Genomic DNA No translation available.
ABGA01254909 Genomic DNA No translation available.
ABGA01254910 Genomic DNA No translation available.
ABGA01254911 Genomic DNA No translation available.
ABGA01254912 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021539

Genome annotation databases

EnsembliENSPPYT00000022419; ENSPPYP00000021539; ENSPPYG00000019234

Phylogenomic databases

eggNOGiKOG2194 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00530000063839
InParanoidiH2PS71
OMAiILNYMVA
TreeFamiTF314836

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2PS71_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2PS71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: October 16, 2019
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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