HGF

Functionⁱ

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

chemoattractant activity Source: Ensembl
growth factor activity Source: UniProtKB-KW
identical protein binding Source: Ensembl
serine-type endopeptidase activity Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Ensembl
cell chemotaxis Source: Ensembl
cell morphogenesis Source: Ensembl
cellular response to hepatocyte growth factor stimulus Source: Ensembl
epithelial cell proliferation Source: Ensembl
hepatocyte growth factor receptor signaling pathway Source: Ensembl
liver development Source: Ensembl
myoblast proliferation Source: Ensembl
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
negative regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of interleukin-6 production Source: Ensembl
negative regulation of peptidyl-serine phosphorylation Source: Ensembl
negative regulation of release of cytochrome c from mitochondria Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of DNA biosynthetic process Source: Ensembl
positive regulation of interleukin-10 production Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
regulation of p38MAPK cascade Source: Ensembl
regulation of tau-protein kinase activity Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factorUniRule annotationARBA annotation, Serine protease homologUniRule annotation

Molecular function

Growth factorUniRule annotationARBA annotation, Serine protease homologUniRule annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.976

MEROPSⁱ

S01.976

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte growth factorUniRule annotationARBA annotation Alternative name(s): Hepatopoietin-AUniRule annotation Scatter factorUniRule annotation
Gene namesⁱ	Name:HGFImported
Organismⁱ	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifierⁱ	9601 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo
Proteomesⁱ	UP000001595 Componentⁱ: Chromosome 7

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	211 ↔ 288	PROSITE-ProRule annotation
Disulfide bondⁱ	232 ↔ 271	PROSITE-ProRule annotation
Disulfide bondⁱ	260 ↔ 283	PROSITE-ProRule annotation
Disulfide bondⁱ	326 ↔ 365	PROSITE-ProRule annotation
Disulfide bondⁱ	354 ↔ 377	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationARBA annotation, Pyrrolidone carboxylic acidARBA annotation

Interactionⁱ

Subunit structureⁱ

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

UniRule annotation

GO - Molecular functionⁱ

chemoattractant activity Source: Ensembl
growth factor activity Source: UniProtKB-KW
identical protein binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000020015

STRINGⁱ

9601.ENSPPYP00000020015

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation

Keywords - Domainⁱ

KringlePROSITE-ProRule annotationARBA annotation

Phylogenomic databases

eggNOGⁱ	ENOG502QR40, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156019
HOGENOMⁱ	CLU_017565_1_0_1
InParanoidⁱ	H2PN16
OMAⁱ	TNIPQCG
Database of Orthologous Groups More...OrthoDBⁱ	164039at2759
TreeFamⁱ	TF329901

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.10.10, 2 hits 2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit
PIRSFⁱ	PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit
PRINTSⁱ	PR00722, CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

H2PN16-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL 
        60         70         80         90        100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP 
       110        120        130        140        150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ 
       160        170        180        190        200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV 
       210        220        230        240        250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKYLPERY 
       260        270        280        290        300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 
       310        320        330        340        350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHHMT PENFKCKDLR 
       360        370        380        390        400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM 
       410        420        430        440        450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP 
       460        470        480        490        500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP 
       510        520        530        540        550
TRTNVGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI 
       560        570        580        590        600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 
       610        620        630        640        650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV 
       660        670        680        690        700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP 
       710        720 
NRPGIFVRVA YYAKWIHKII LTYKVPQS

Length:728

Mass (Da):83,158

Last modified:March 21, 2012 - v1

Checksum:ⁱ2744611667778F35

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_002818342.1, XM_002818296.3

RefSeqⁱ

XP_002818342.1, XM_002818296.3

Genome annotation databases

Ensemblⁱ	ENSPPYT00000020805; ENSPPYP00000020015; ENSPPYG00000017860
GeneIDⁱ	100462115
KEGGⁱ	pon:100462115

Protein	Similar proteins		Species	Score	Length	Source
H2PN16	Hepatocyte growth factor		PONAB		728	UniRef100_H2PN16

Protein	Similar proteins		Species	Score	Length	Source
H2PN16	Hepatocyte growth factor		PONAB		728	UniRef90_H2PN16
Hepatocyte growth factor		CARSF		732
Hepatocyte growth factor		HUMAN		728
Hepatocyte growth factor		SAPAP		723
Hepatocyte growth factor		CERAT		715
+15

Protein	Similar proteins		Species	Score	Length	Source
H2PN16	Hepatocyte growth factor	)	HUMAN		728	UniRef50_P14210
Hepatocyte growth factor		CANLF		730
Hepatocyte growth factor		BOVIN		730
Hepatocyte growth factor		FELCA		728
Hepatocyte growth factor	)	MOUSE		728
+631

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_002818342.1, XM_002818296.3

RefSeqⁱ

XP_002818342.1, XM_002818296.3

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000020015

STRINGⁱ

9601.ENSPPYP00000020015

Protein family/group databases

MEROPSⁱ	S01.976

MEROPSⁱ

S01.976

Genome annotation databases

Ensemblⁱ	ENSPPYT00000020805; ENSPPYP00000020015; ENSPPYG00000017860
GeneIDⁱ	100462115
KEGGⁱ	pon:100462115

Organism-specific databases

CTDⁱ	3082

CTDⁱ

3082

Phylogenomic databases

eggNOGⁱ	ENOG502QR40, Eukaryota
GeneTreeⁱ	ENSGT00940000156019
HOGENOMⁱ	CLU_017565_1_0_1
InParanoidⁱ	H2PN16
OMAⁱ	TNIPQCG
OrthoDBⁱ	164039at2759
TreeFamⁱ	TF329901

Family and domain databases

CDDⁱ	cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.10.10, 2 hits 2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom
Pfamⁱ	View protein in Pfam PF00051, Kringle, 4 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit
PIRSFⁱ	PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit
PRINTSⁱ	PR00722, CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021, KRINGLE_1, 4 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2PN16_PONAB
Accessionⁱ	H2PN16Primary (citable) accession number: H2PN16 Secondary accession number(s): A0A2J8VLJ2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 21, 2012
	Last sequence update:	March 21, 2012
	Last modified:	December 2, 2020
	This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H2PN16 (H2PN16_PONAB)

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Hepatocyte growth factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ