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Protein

Ribosomal protein S6 kinase

Gene

RPS6KA2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167ATPUniRule annotation1
Active sitei260Proton acceptorUniRule annotation1
Binding sitei520ATPUniRule annotation1
Active sitei608Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi141 – 149ATPUniRule annotation9
Nucleotide bindingi497 – 505ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinaseUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:RPS6KA2Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 6

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019227

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 394Protein kinaseInterPro annotationAdd BLAST260
Domaini395 – 464AGC-kinase C-terminalInterPro annotationAdd BLAST70
Domaini491 – 748Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
InParanoidiH2PKU9
OMAiTMDYLHS
OrthoDBiEOG091G05Z7
TreeFamiTF313438

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016239 Ribosomal_S6_kinase_II
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 2 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

Sequencei

Sequence statusi: Complete.

H2PKU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRGRRRRE RLRPRPRWPA RPALCFRSPR PTPRAHGRRA GLPGHACPPA
60 70 80 90 100
DLSPAPWDAG DARPPALRLL RAGRGAMDLS MKKFAVRRFF SVYLRRKSRS
110 120 130 140 150
KSSSLSRLEE EGVVKEIDIS HHVKEGFEKA DPSQFELLKV LGQGSYGKVF
160 170 180 190 200
LVRKVKGSDA GQLYAMKVLK KATLKVRDRV RSKMERDILA EVNHPFIVKL
210 220 230 240 250
HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY LAELALALDH
260 270 280 290 300
LHSLGIIYRD LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE
310 320 330 340 350
YMAPEVVNRR GHTQSADWWS FGVLMFEMLT GSLPFQGKDR KETMALILKA
360 370 380 390 400
KLGMPQFLSG EAQSLLRALF KRNPCNRLGA GIDGVEEIKR HPFFVTIDWN
410 420 430 440 450
TLYRKEIKPP FKPAVGRPED TFHFDPEFTA RTPTDSPGVP PSANAHHLFR
460 470 480 490 500
GFSFVASSLI QEPSQQDLHK VPVHPIVQQL HGNNIHFTDG YEIKEDIGVG
510 520 530 540 550
SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD
560 570 580 590 600
VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH
610 620 630 640 650
SQGVVHRDLK PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT
660 670 680 690 700
ANFVAPEVLK RQGYDAACDI WSLGILLYTM LAGFTPFANG PDDTPEEILV
710 720 730 740 750
RIGSGKYALS GGNWDSISDA AKDVVSKMLH VDPHQRLTAM QVLKHPWVVN
760 770 780 790 800
REYLSPNQLS RQDVHLVKGA MAATYFALNR TPQAPRLEPV LSSNLAQRRG

MKRLTSTRL
Length:809
Mass (Da):91,763
Last modified:January 9, 2013 - v2
Checksum:iF61AAD558ACBC048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01183150 Genomic DNA No translation available.
ABGA01183151 Genomic DNA No translation available.
ABGA01183152 Genomic DNA No translation available.
ABGA01183153 Genomic DNA No translation available.
ABGA01183154 Genomic DNA No translation available.
ABGA01183155 Genomic DNA No translation available.
ABGA01183156 Genomic DNA No translation available.
ABGA01183157 Genomic DNA No translation available.
ABGA01183158 Genomic DNA No translation available.
ABGA01183159 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSPPYT00000019984; ENSPPYP00000019227; ENSPPYG00000017167

Similar proteinsi

Entry informationi

Entry nameiH2PKU9_PONAB
AccessioniPrimary (citable) accession number: H2PKU9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: June 20, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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