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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi367Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi384Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi424Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
ORF Names:CR201_G0040764Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 6

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi9601.ENSPPYP00000018731

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiKOG2267 Eukaryota
    COG2219 LUCA
    GeneTreeiENSGT00390000009790
    InParanoidiH2PJG8
    KOiK02685
    OMAiDCHGCPY
    OrthoDBiEOG091G08G7
    TreeFamiTF105893

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

    Sequencei

    Sequence statusi: Complete.

    H2PJG8-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MEFSGRKWKT LRLAGDQRNA SYPHCLQFYL QPPCENISLI EFENLAIDRV
    60 70 80 90 100
    KLLKSVENLG VSYMKGTEQY QSKLESELRK LKFSYRENLE DEYEPRRRDH
    110 120 130 140 150
    ISHFILRLAY CQSEELRRWF IQQEMDLLRF RFSILPKDKI QDFLKDSQLQ
    160 170 180 190 200
    FEAISDEEKT LRDQEIIASS PSLSGLKLGF ESIYKIPFAD ALDLFRGRKV
    210 220 230 240 250
    YLEDGFAYVP LKDIVAIILN EFRAKLSKAL ALTARSLPAV QSDERLQPLL
    260 270 280 290 300
    NHLSHSYTGQ DYSTQGNVGK ISLDQIDSLS TKSFPPCMRQ LHKALRENHH
    310 320 330 340 350
    LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIKGKMDPDK FDKGYSYNIR
    360 370 380 390 400
    HSFGKEGKRT DYTPFSCLKI ILSNPPSQGD YHGCPFRHSD PELLKQKLQS
    410 420 430 440 450
    YKISPGGISQ ILDLVKGTHY QVACQKYFEM IHNVDDCGFS LNHPNQFFCE
    460 470 480 490 500
    SQRILNGGKD IKKEPIQPET PQPKPSVQKT KDASSALASL NSSLEMDMEG

    LEDYFSEDS
    Length:509
    Mass (Da):58,773
    Last modified:January 9, 2013 - v2
    Checksum:i913893D06660C7AB
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    ABGA01283624 Genomic DNA No translation available.
    ABGA01283625 Genomic DNA No translation available.
    ABGA01283626 Genomic DNA No translation available.
    ABGA01283627 Genomic DNA No translation available.
    ABGA01283628 Genomic DNA No translation available.
    ABGA01283629 Genomic DNA No translation available.
    ABGA01283630 Genomic DNA No translation available.
    ABGA01283631 Genomic DNA No translation available.
    ABGA01283632 Genomic DNA No translation available.
    ABGA01283633 Genomic DNA No translation available.
    NDHI03003550 Genomic DNA Translation: PNJ23843.1
    RefSeqiXP_002817077.1, XM_002817031.3
    XP_009240263.1, XM_009241988.1

    Genome annotation databases

    EnsembliENSPPYT00000019473; ENSPPYP00000018731; ENSPPYG00000016740
    GeneIDi100433634
    KEGGipon:100433634

    Similar proteinsi

    Entry informationi

    Entry nameiH2PJG8_PONAB
    AccessioniPrimary (citable) accession number: H2PJG8
    Secondary accession number(s): A0A2J8SSV1
    Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: January 9, 2013
    Last modified: May 23, 2018
    This is version 33 of the entry and version 2 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

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