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Entry version 37 (02 Dec 2020)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000016647

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini922 – 1183AF-4_CInterPro annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni75 – 316DisorderedSequence analysisAdd BLAST242
Regioni367 – 930DisorderedSequence analysisAdd BLAST564
Regioni1065 – 1093DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 37PolyampholyteSequence analysisAdd BLAST26
Compositional biasi99 – 135PolarSequence analysisAdd BLAST37
Compositional biasi168 – 191PolyampholyteSequence analysisAdd BLAST24
Compositional biasi214 – 242PolarSequence analysisAdd BLAST29
Compositional biasi372 – 427PolarSequence analysisAdd BLAST56
Compositional biasi460 – 487PolarSequence analysisAdd BLAST28
Compositional biasi586 – 606PolarSequence analysisAdd BLAST21
Compositional biasi709 – 731PolarSequence analysisAdd BLAST23
Compositional biasi783 – 836PolyampholyteSequence analysisAdd BLAST54
Compositional biasi850 – 867PolyampholyteSequence analysisAdd BLAST18
Compositional biasi882 – 901PolyampholyteSequence analysisAdd BLAST20
Compositional biasi902 – 917PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2PDU2

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2PDU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQSSLYND DRNLLRIREK ERRNQEAHQE KEAFPEKIPL FGEPYKTAKG
60 70 80 90 100
DELSSRIQNM LGNYEEVKEF LSTKSHTHRL DAPENRLGKP KYPLIPDKGS
110 120 130 140 150
SIPSSSFHTS VHHQSIHTPA SGPLSVGSIS HNPKMAQPRT EPMPSLHAKS
160 170 180 190 200
CGPPDSQHLT QDRLGQEGFG SSHHKKGDRR ADGDHCASVT DSAPEREPSP
210 220 230 240 250
LISSLPSPVP PLSPIHSNQQ TLPRTQGSSK VHGSNNNSKG CCPAKSPKDL
260 270 280 290 300
AVKVHDKETP QDSLVAPAQP PSQTFPPPSL PSKSVAMQQK PTAYVRPMDG
310 320 330 340 350
QDQAPSESPE LKPLPEDYRQ QTFEKTDLKV PAKAKLTKLK MPSQSVELTY
360 370 380 390 400
SNEVHCVEEI LKEMTHSWPP PLTAIHTPST AEPSKFPFPT KDSQHVSSVT
410 420 430 440 450
QNQKQYDTSS KTHSNSQQGT SSMLEDDLQL SDSEDSDSEQ TPEKPPSSSA
460 470 480 490 500
PPSAPQSLPE PVASAHSSSA ESESTSDSDS SSDSESESSS SDSEENEPLE
510 520 530 540 550
TPAPEPEPPT TNKWQLDNWL TKVSQPAAPL EGPGSTEPPR RHPESKGSSD
560 570 580 590 600
SATSQEHSES KDPPPKSSSK ALRAPPEAPH PGKRSCQKSP AQQEPPQRQT
610 620 630 640 650
VGTKQPKKPV KASARAGSRA SLQGEREPGL LPYGSRDQTS KDKPKVKTKG
660 670 680 690 700
RPRAAASNEP KPAVPPSSEK KKHKSSLPAP SKAPSGPEPT KDNVEDRSPE
710 720 730 740 750
HFALVPLTQS QGPPHSGSGS GSRTSGCRQA VVVQEDSRKD RLPLPLRDTK
760 770 780 790 800
LLSPLRDTPP PQSLMVKITL DLLSRIPQPP GKRSRQRKAE DKQPPAGKKH
810 820 830 840 850
SSEKRSSDSS SKLAKKRKGE AERDCDNKKI RLEKEIKSQS SSSSSSHKES
860 870 880 890 900
SKTPAHKRSR READTCCDPP KSASSTKSNH KDSSIPKQRR VEGKGSRSSS
910 920 930 940 950
EHKGSSGDTA NPFPVPSLPN GNSKPGKPQV KFDKQQADLH MREAKKMKQK
960 970 980 990 1000
AELMTDKVGK AFKYLEAVLS FIECGIATES ESQASKSAYS VYSETVDLIK
1010 1020 1030 1040 1050
FIMSLKSFSD ATAPTQEKIF AVLCMRCQSI LNMAMFRCKK DIAIKYSRTL
1060 1070 1080 1090 1100
NKHFESSSKV AQAPSPCIAR STGTPSPLSP MPSPASSVGS QSSAGSVGSS
1110 1120 1130 1140 1150
GVAATISTPV TIQNMTSSYV TITSHVLTAF DLWEQAEALT RKNKEFFARL
1160 1170 1180
STNVCTLALN SSLVDLVHYT RQGFQQLQEL TKTP
Length:1,184
Mass (Da):128,566
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DC7F17567F13120
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000017326; ENSPPYP00000016647; ENSPPYG00000014910

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016647

Genome annotation databases

EnsembliENSPPYT00000017326; ENSPPYP00000016647; ENSPPYG00000014910

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiH2PDU2
OMAiYMAMFRY
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 2 hits
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2PDU2_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2PDU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: December 2, 2020
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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